A5073726708- Mosquito-borne diseases and control
- Malaria Research and Control
- Parasites and Host Interactions
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Invertebrate Immune Response Mechanisms
- COVID-19 Clinical Research Studies
- Travel-related health issues
- Parasite Biology and Host Interactions
- Viral Infections and Outbreaks Research
- Immune responses and vaccinations
- Vector-borne infectious diseases
- Virology and Viral Diseases
- Global Maternal and Child Health
- Psychosomatic Disorders and Their Treatments
- Vaccine Coverage and Hesitancy
- Health disparities and outcomes
- Optimism, Hope, and Well-being
- Reproductive System and Pregnancy
London School of Hygiene & Tropical Medicine
2019-2025
University of London
2021-2023
Infectious Diseases Research Collaboration
2019-2020
Centers for Disease Control and Prevention
2020
MRC Unit the Gambia
2019-2020
Bernhard Nocht Institute for Tropical Medicine
2019-2020
Statens Serum Institut
2019-2020
University of Copenhagen
2019-2020
Swansea University
2014
BackgroundLand use changes disrupt ecosystems, altering the transmission of vector-borne diseases. These have been associated with increasing incidence zoonotic malaria caused by Plasmodium knowlesi; however, population-level distributions infection and exposure remain unknown. We aimed to measure prevalence serological P knowlesi assess risk factors.MethodsWe did an environmentally stratified, population-based, cross-sectional survey across households in Kudat, Kota Marudu, Pitas, Ranau...
Abstract Plasmodium falciparum gametocyte kinetics and infectivity may differ between chronic incident infections. In the current study, we assess parasite to mosquitoes among children (aged 5–10 years) from Burkina Faso with (a) infections following clearance ( n = 48) (b) asymptomatic 60). infection cohort, 92% (44/48) of develop symptoms within 35 days, compared 23% (14/60) in cohort. All individuals carried gametocytes or developed them during follow-up, whereas only 35% (17/48) cohort...
<ns3:p><ns3:bold>Background:</ns3:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
<ns4:p><ns4:bold>Background:</ns4:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
Cerebral malaria is a common presentation of severe Plasmodium falciparum infection and remains an important cause death in the tropics. Key aspects its pathogenesis are still incompletely understood, but brain swelling identified by magnetic resonance imaging (MRI) was associated with fatal outcome African children. In contrast, neuroimaging investigations failed to identify cerebral features fatality Asian adults. Quantitative MRI volume assessment apparent diffusion coefficient (ADC)...
Abstract During the COVID-19 pandemic, heterologous vaccination strategies were employed to alleviate strain on vaccine supplies. The Thailand Ministry of Health adopted these using vector, inactivated, and mRNA vaccines. However, this approach has introduced challenges for SARS-CoV-2 sero-epidemiology studies. Our study analysed 647 samples from healthcare workers who received CoronaVac, ChAdOx1 nCoV-19, BNT162b2 serological profile encompassed responses various variants vectors, measuring...
This research identified psychosocial factors associated with post-traumatic stress and health anxiety following a venous thrombotic embolism. In all, 158 participants, largely registered embolism information website (Lifeblood: The Thrombosis Charity), completed an online survey. Post-traumatic symptom scores were linked to threat, not moderated by perceived control over risk for further Health was continuing symptoms negative emotional response the There is need intervene reduce both...
HIV-1 infection disproportionately affects women in sub-Saharan Africa, where areas of high prevalence and Schistosoma haematobium endemicity largely overlap. Female genital schistosomiasis (FGS), an inflammatory disease caused by S. egg deposition the tract, has been associated with prevalent infection. Elevated levels chemokines MIP-1α (CCL-3), MIP-1β (CCL-4), IP-10 (CXCL-10), IL-8 (CXCL-8) cervicovaginal lavage (CVL) have acquisition. We hypothesize that cytokines may be raised FGS could...
Abstract Background Cerebral malaria in adults is associated with brain hypoxic changes on magnetic resonance (MR) images and has a high fatality rate. Findings of neuroimaging studies suggest that involvement also occurs patients uncomplicated (UM) or severe noncerebral (SNCM) without coma, but such features were never rigorously characterized. Methods Twenty UM 21 SNCM underwent MR imaging admission 44–72 hours later, as well plasma analysis. Apparent diffusion coefficient (ADC) maps...
The epidemiology of malaria changes as prevalence falls in low-transmission settings, with remaining infections becoming more difficult to detect and diagnose. At this stage active surveillance is critical residual hotspots transmission. However, diagnostic tools used generally only concurrent infections, surveys may benefit from sensitive such serological assays. Serology can be interrogate characterize individuals' previous exposure over longer durations, providing information essential...
Background Infectious diseases continue to burden populations in Malaysia, especially among rural communities where resources are limited and access health care is difficult. Current epidemiological trends of several neglected tropical these at present absent due the lack habitual efficient surveillance. To date, various studies have explored utility serological multiplex beads monitor numerous simultaneously. We therefore applied this platform assess population level exposure six infectious...
Mosquito saliva elicits immune responses in humans following mosquito blood feeding. Detection of human antibodies recognizing the Anopheles gambiae salivary gland protein 6 (gSG6) or gSG6-P1 peptide residents Africa, South America and Southeast Asia suggested potential for these to serve as a universal marker estimate biting rates. Validating utility this approach requires concurrent comparisons anopheline rates with gSG6 determine sensitivity specificity assay monitoring changes vector...
Abstract Malaysia has reported no indigenous cases of P. falciparum and vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals locations where exposure risks are high, as they may be at greater risk in case a resurgence transmission. Serology useful tool settings, providing insight into longer durations than PCR or RDT. We ran blood samples from 2015 population-based survey northern Sabah, Malaysian Borneo on multiplex bead assay....
Due to challenges in measuring changes malaria at low transmission, serology is increasingly being used complement clinical and parasitological surveillance. Longitudinal studies have shown that serological markers, such as Etramp5.Ag1, can reflect spatio-temporal differences transmission. However, these markers yet be endpoints intervention trials.
The Indian state of Odisha has a longstanding battle with forest malaria. Many remote and rural villages have poor access to health care, problem that is exacerbated during the rainy season when malaria transmission at its peak. Approximately 62% population consists tribal groups who are among communities most negatively impacted by To address persistently high rates in these regions, State Malaria Control Program introduced 'malaria camps' 2017 where teams workers visit educate population,...
Abstract We longitudinally assessed P. falciparum parasite kinetics, gametocyte production and infectivity in incident infections that were naturally acquired following infection clearance chronic asymptomatic Burkina Faso. 92% (44/48) of the cohort developed symptoms treated within 35 days, compared to 23% (14/60) cohort. All but two individuals with gametocytaemic at enrollment, whereas only 35% (17/48) gametocytes days. The relative abundance ap2-g transcripts was positively associated...
ObjectivesWe assessed the prevalence of immunoglobulin G (IgG) and IgM against four endemic human coronaviruses two SARS-CoV-2 antigens among vaccinated unvaccinated staff at health care centers in Uganda, Sierra Leone, Democratic Republic Congo.MethodsThe government facility who had patient contact Goma (Democratic Congo), Kambia District (Sierra Leone), Masaka (Uganda) were enrolled. Questionnaires blood samples collected three time points over 4 months. Blood analyzed with Luminex...
Abstract Objectives We assessed the prevalence of immunoglobulin G (IgG) and M (IgM) against four endemic human coronaviruses (HCoVs) two SARS-CoV-2 antigens, among vaccinated unvaccinated staff at health care centres in Uganda, Sierra Leone, Democratic Republic Congo (DRC). Methods Government facility who had patient contact Goma (DRC), Kambia District (Sierra Leone), Masaka (Uganda) were enrolled. Questionnaires blood samples collected three timepoints over months. Blood analysed with...
We assessed whether the immunogenicity of two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen with a 56-day interval between doses was affected by exposure to malaria before dose 1 vaccination and clinical episodes in period immediately after 2 vaccinations. Previous participants an trial Sierra Leone (ClinicalTrials.gov: NCT02509494) classified as low, intermediate, high according their antibody responses panel Plasmodium falciparum antigens detected using Luminex MAGPIX platform....
Abstract Due to challenges in measuring changes malaria low transmission settings, serology is increasingly being used complement clinical and parasitological surveillance. Longitudinal cohort studies have shown serological markers, such as Etramp5.Ag1, be particularly discriminatory of spatio-temporal differences transmission. However, these markers yet endpoints intervention trials. This study an extended analysis a 2017 cluster randomised trial conducted Zambezi Region, Namibia,...
Due to challenges in measuring changes malaria at low transmission, serology is increasingly being used complement clinical and parasitological surveillance. Longitudinal studies have shown that serological markers, such as Etramp5.Ag1, are discriminatory of spatio-temporal differences transmission. However, these markers yet be endpoints intervention trials. Based on a 2017 cluster randomised trial conducted Zambezi Region, Namibia, evaluating the effectiveness reactive focal mass drug...