A5072615536- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Reproductive tract infections research
- Global Maternal and Child Health
- Syphilis Diagnosis and Treatment
- Parasitic Diseases Research and Treatment
- Economic and Business Development Strategies
- Cervical Cancer and HPV Research
- Complement system in diseases
- Insect Resistance and Genetics
- vaccines and immunoinformatics approaches
- Dermatological diseases and infestations
- Helminth infection and control
- Urinary Tract Infections Management
- Adolescent Sexual and Reproductive Health
- Inflammasome and immune disorders
- Library Science and Information Literacy
- Herpesvirus Infections and Treatments
- Regional Development and Management Studies
- HIV Research and Treatment
- Geochemistry and Geologic Mapping
- Educational Innovations and Challenges
- Education and Critical Thinking Development
- Remote-Sensing Image Classification
London School of Hygiene & Tropical Medicine
2018-2024
MRC Unit the Gambia
2019-2024
University Medical Center Utrecht
2023
Utrecht University
2023
Infectious Diseases Research Collaboration
2019-2020
Centers for Disease Control and Prevention
2020
Bernhard Nocht Institute for Tropical Medicine
2019-2020
Statens Serum Institut
2019-2020
University of Copenhagen
2019-2020
University of Economics Varna
2019
<ns3:p><ns3:bold>Background:</ns3:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
<ns4:p><ns4:bold>Background:</ns4:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
As malaria declines, innovative tools are required to further reduce transmission and achieve elimination. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) is capable reducing where coverage control interventions already high, though the impact short-lived. Combining ACT with ivermectin, an oral endectocide shown vector survival, may increase its impact, while also treating ivermectin-sensitive co-endemic diseases minimising potential resistance in this...
Abstract Background Insecticide resistance is reducing the efficacy of vector control interventions, consequently threatening efforts to vector-borne diseases, including malaria. Investigating prevalence molecular markers a useful tool for monitoring spread insecticide in disease vectors. The Bijagós Archipelago (Bijagós) Guinea-Bissau region stable malaria transmission where insecticide-treated nets are mainstay control. However, vectors not well understood. Methods A total 214 Anopheles...
Background The presence of Chlamydia trachomatis (Ct) DNA at non-ocular sites suggests that these may represent plausible routes Ct transmission in trachoma. However, qPCR cannot discriminate between from viable and non-viable bacteria. Here we use a propodium monoazide based viability PCR to investigate how long remains under laboratory-controlled conditions. Methods Cultured stocks (strain A2497) were diluted final concentrations 1000, 100, 10 1 omcB copies/μL applied plastic, woven mat,...
Arthropod vectors feeding on the blood of individuals treated with ivermectin have substantially increased mortality. Whether this effect will translate into a useful tool for reducing malaria burden at scale is not clear. Our trial aimed to assess whether using as an adjunct mass drug administration (MDA) dihydroartemisinin-piperaquine would further reduce prevalence.
Abstract Following integrated malaria control interventions, burden on the Bijagós Archipelago has significantly decreased. Understanding genomic diversity of circulating Plasmodium falciparum parasites can assist infection control, through identifying drug resistance mutations and characterising complexity population structure. This study presents first whole genome sequence data for P. isolates from Archipelago. Amplified DNA sourced dried blood spot samples 15 asymptomatic cases were...
Complications from sexually transmitted infections (STIs) can result in severe morbidity and mortality. To date, no STI population studies have been conducted on the Bijagos Islands, Guinea Bissau. Our objective was to estimate prevalence of identify risk factors for
Abstract Background The prevalence of sexually transmitted infections (STIs) in sub-Saharan Africa is poorly described. We aimed to determine the five treatable STIs ( Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, Treponema pallidum ) a sample Gambian women from general population. Methods Archived specimens 420 aged 15 − 69 years living Gambia enrolled clinical trial human papilloma virus vaccine schedules were tested this study. Urine samples...
ObjectivesIvermectin, used to control several neglected tropical diseases, may also reduce malaria transmission. Mass drug administration (MDA) for therefore might have off-target impacts on diseases.MethodsIn The Gambia, nested in a trial of ivermectin MDA, cross-sectional surveys measuring ectoparasites and soil-transmitted helminths children aged 3 14 years took place June November 2019 2021.ResultsAfter scabies prevalence was 41.2% (237/576) the 38.2% (182/476) intervention arm (odds...
Distribution of long-lasting insecticide-treated nets (LLINs), passive detection and treatment with artemisinin-based combination therapy (ACT), intermittent preventive in pregnancy (IPTp) are the mainstay malaria control measures Guinea-Bissau's national programme. This study aimed to estimate prevalence Plasmodium falciparum on Bubaque, most populous island country's remote Bijagos archipelago. A cross-sectional survey was performed at start rainy season August 2017. Participants were...
Clinical signs of active (inflammatory) trachoma are found in many children the Solomon Islands, but majority these individuals have no serological evidence previous infection with Chlamydia trachomatis. In Temotu and Rennell Bellona provinces, ocular infections C. trachomatis were seldom detected among trachoma; a similar lack association was seen between other common bacterial viral causes follicular conjunctivitis. Here, we set out to characterise patterns gene expression at conjunctivae...
Abstract Background Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over last two decades. Successful implementation MDA programmes requires community participation and can be threatened by systematic non-participation. Such concerns are particularly pertinent against malaria, as they require multi-day treatment consecutive months. Factors associated with non-participation to campaign ivermectin (IVM) dihydroartemisinin-piperaquine (DHP) implemented...
Advancements in modern technologies, such as remote sensing systems and instruments have led to rapid developments the field of Earth observation /EO/. As a result, enormous volumes EO data with various spatial spectral resolutions are obtained. However, expected enhancements classification accuracy still not been reached, due complexity measurements big volume that need be processed. The last leads necessity development improvement methods techniques for obtaining analysis. include...
E. Tsvetkova, Savova, H. VasilevaUniversity of Library Studies and Information Technologies (BULGARIA)
Abstract Malaria caused by Plasmodium spp . leads to significant morbidity and mortality, particularly in Sub-Saharan African countries with falciparum being the predominant infectious species. The pathogenesis of P. depends on multiple host parasitic factors, one which is evasion immune response due antigenic variability during blood stage infection. understudied infected erythrocyte expressed protein families STEVOR RIFIN characterize hypervariability are associated clinical outcome...
Abstract Background Malaria pathogenesis is dependent on complex interactions between host and parasite factors, where variant surface antigens such as the Pf EMP1 protein family play a critical role in disease severity through various mechanisms, including immune evasion, cytoadherence sequestration. The under characterised infected erythrocytes surface-expressed of STEVOR are also implicated rosette formation exhibiting high antigenic variability, potentially contributing to evasion. This...
Abstract Background : Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over last two decades. Successful implementation MDA programs requires community participation and can be threatened by systematic non-participation. Such concerns are particularly pertinent programmes against malaria, as they require multi-day treatment consecutive months. Factors associated with non-participation to campaign ivermectin (IVM) dihydroartemisinin-piperaquine (DHP)...
SMEs are one of the most widely used business models in today's economy. This explains great scientific and applied interest them as elements economic system that is subject to constant study. For purposes SME management, essence this concept needs be clearly defined. There two approaches defining it, quantitative qualitative. In specialist literature, each has both advantages disadvantages. The present study provides a critical analysis existing approaches, on basis which new comprehensive...
LEADERSHIP SKILLS, ATTITUDES AND PRACTICES AS A MECHANISM TO DEAL WITH CONFLICT OF INTEREST IN THE UNIVERSITY INFORMATION ENVIRONMENT
S. Denchev, M. Pavlova, R. Yotova, H. VasilevaUniversity of Library Studies and Information Technologies (BULGARIA)