A5073696029- Dermatological diseases and infestations
- Parasites and Host Interactions
- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasitic Diseases Research and Treatment
- Viral Infections and Vectors
- Cultural Competency in Health Care
- Parasitic infections in humans and animals
- Helminth infection and control
- Travel-related health issues
- Congenital Anomalies and Fetal Surgery
- Vector-borne infectious diseases
- Syphilis Diagnosis and Treatment
- Tumors and Oncological Cases
- Vestibular and auditory disorders
- Insects and Parasite Interactions
- Clostridium difficile and Clostridium perfringens research
- Hearing, Cochlea, Tinnitus, Genetics
- Circadian rhythm and melatonin
- Tryptophan and brain disorders
- Vaccine Coverage and Hesitancy
- Connexins and lens biology
- Reproductive tract infections research
- Island Studies and Pacific Affairs
- Neuroinflammation and Neurodegeneration Mechanisms
London School of Hygiene & Tropical Medicine
2017-2024
Swiss Tropical and Public Health Institute
2024
University of Basel
2024
University of London
2019-2021
Kantonsspital St. Gallen
2014-2019
University of St. Gallen
2018
Klinikum rechts der Isar
2016
Innsbruck Medical University
2010-2012
Vienna Biocenter
2008
Scabies is a public health problem in many countries, with impetigo and its complications important consequences. Ivermectin based mass drug administration (MDA) reduces the prevalence of scabies and, to lesser extent, impetigo. We studied impact co-administering azithromycin on antimicrobial resistance. Six communities were randomized receive either ivermectin-based MDA or co-administered azithromycin. measured at baseline 12 months. collected lesions swabs baseline, 3 months detect At...
<i>Background/Aims:</i> The immunologic background of allergic asthma and rhinitis includes a preponderance Th2-type immunity. In parallel, Th1-type immune response is suppressed by cytokines. As consequence, biochemical pathways triggered cytokine interferon-γ, such as tryptophan degradation indoleamine 2,3-dioxygenase neopterin production, might be altered. We examined whether they are related to the outcome hyposensitization therapy in atopic patients....
Background Scabies and head lice are ubiquitous ectoparasitic infestations that common across the Pacific Islands. Ivermectin is an effective treatment for both conditions, although doses used vary. At a community level, mass drug administration (MDA) with ivermectin strategy to decrease prevalence of scabies. To what extent MDA will also reduce unknown. Methodology Head was assessed before after oral (at dose 200 micrograms per kilogram body weight) administered on day 1 8. The primary...
The frequency of Taenia solium, a zoonotic helminth, is increasing in many countries sub-Saharan Africa, where the prevalence human immunodeficiency virus (HIV) also high. However, little known about how these two infections interact. aim this study was to compare proportion HIV positive (+) and negative (−) individuals who are infected with solium (TSOL) present clinical neurological manifestations cysticercosis (CC). In northern Tanzania, 170 HIV+ HIV– controls matched for gender, age...
In Africa, urbanization is happening faster than ever before which results in new implications for transmission of infectious diseases. For the zoonotic parasite Taenia solium, a major cause acquired epilepsy endemic countries, prevalence urban settings unknown. The present study investigated epidemiological, neurological, and radiological characteristics T. solium cysticercosis taeniasis (TSCT) people with (PWE) living Dar es Salaam, Tanzania, one fastest growing cities worldwide. A total...
With a decline in malaria burden, innovative interventions and tools are required to reduce transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as potential tool further transmission, where coverage vector control is already high. However, the impact limited time. Combining an ACT with endectocide treatment that able survival, such ivermectin (IVM), could increase MDA offer new transmission.The study objective evaluate IVM...
Plasmodium falciparum malaria has been suspected to cause hearing loss. Developmental, cognitive and language disorders have observed in children, surviving cerebral malaria. This prospective study aims evaluate whether influences mice. Twenty mice were included a standardized murine model. Auditory evoked brainstem responses assessed before infection at the peak of illness. A significant impairment could be demonstrated with malaria, especially form. The control group did not show any...
Experimental murine malaria has been shown to result in significant hearing impairment. Microscopic evaluation of the temporal bones these animals revealed regular morphology cochlea duct. Furthermore, known vascular pathologic changes being associated with could not be found. Immunohistochemistry for ICAM1 showed a strong marking stria vascularis, indicating disturbance endocochlear potential. The aim this study was evaluate role apoptosis and blood labyrinth barrier
Abstract The prevalence of antibodies to Strongyloides stercoralis was measured in 0–12-year-olds using a bead-based immunoassay before and after ivermectin mass drug administration (MDA) for scabies the Solomon Islands. Seroprevalence 9.3% 5.1% MDA (P = .019), demonstrating collateral benefits this setting.
Summary Objective To evaluate the pathophysiologic changes in inner ear during course of severe cerebral malaria an established animal model, C57 BL/6J mice. Methods This study aims to examine hearing threshold, histological and ICAM‐1 expression murine cochlea. Results Four seven mice showed expected loss 20 dB or more. The light microscopy did not show any morphologic alterations. immunohistochemical analysis for intensive staining stria vascularis sick animals hardly reaction healthy...
The Solomon Islands is targeting elimination of malaria by 2030. dominant vector the predominantly exophagic, exophilic Anopheles farauti sensu strictu. This biting behaviour limits efficacy conventional control tools and highlights need for new strategies. When administered to humans ivermectin has been shown have a mosquitocidal effect. Mass drug administration (MDA) with an emerging strategy in scabies. In this study we explored any incidental effect MDA conducted scabies on mosquitoes....
ObjectivesIvermectin, used to control several neglected tropical diseases, may also reduce malaria transmission. Mass drug administration (MDA) for therefore might have off-target impacts on diseases.MethodsIn The Gambia, nested in a trial of ivermectin MDA, cross-sectional surveys measuring ectoparasites and soil-transmitted helminths children aged 3 14 years took place June November 2019 2021.ResultsAfter scabies prevalence was 41.2% (237/576) the 38.2% (182/476) intervention arm (odds...
Yaws, caused by Treponema pallidum subsp. pertenue, is an important public health problem in many tropical countries.1 Like syphilis, the disease manifests three stages; however, unlike its route of transmission non-genital skin-to-skin contact and not sexual intercourse. Primary yaws as either a papilloma or chronic ulcer. Typically, ulcers are painless, with raised edge friable base (Figure 1 ). In secondary yaws, skin manifestations, involvement bones joints including periostitis have...
Abstract Background Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over last two decades. Successful implementation MDA programmes requires community participation and can be threatened by systematic non-participation. Such concerns are particularly pertinent against malaria, as they require multi-day treatment consecutive months. Factors associated with non-participation to campaign ivermectin (IVM) dihydroartemisinin-piperaquine (DHP) implemented...
<sec> <title>BACKGROUND</title> With a decline in malaria burden, innovative interventions and tools are required to reduce transmission further. Mass drug administration (MDA) of artemisinin-based combination therapy (ACT) has been identified as potential tool further transmission, where coverage vector control is already high. However, the impact limited time. Combining an ACT with endectocide treatment that able survival, such ivermectin (IVM), could increase MDA offer new transmission....
Wir stellen den Fall eines 77-jährigen Mannes vor, bei dem ein unklares Fieber auftrat, das trotz detaillierten Abklärungen zunächst unklar blieb. Erst die Serologie brachte am Schluss Diagnose Q-Fiebers. Retrospektiv passen Anamnese und Befunde gut zu einem akuten Q-Fieber.