A5107964357- Malaria Research and Control
- Mosquito-borne diseases and control
- vaccines and immunoinformatics approaches
- Metabolomics and Mass Spectrometry Studies
- Complement system in diseases
- Metabolism and Genetic Disorders
- Zoonotic diseases and public health
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Travel-related health issues
- Protein Hydrolysis and Bioactive Peptides
- HIV Research and Treatment
- Mass Spectrometry Techniques and Applications
- Enzyme Production and Characterization
- Isotope Analysis in Ecology
- Tuberculosis Research and Epidemiology
- Pharmacovigilance and Adverse Drug Reactions
- Analytical Chemistry and Chromatography
- Probiotics and Fermented Foods
- Computational Drug Discovery Methods
University of Copenhagen
2018-2023
University of Lucknow
2022
Bernhard Nocht Institute for Tropical Medicine
2019-2020
Statens Serum Institut
2018-2020
London School of Hygiene & Tropical Medicine
2019-2020
Infectious Diseases Research Collaboration
2019-2020
MRC Unit the Gambia
2019-2020
Centers for Disease Control and Prevention
2020
<ns3:p><ns3:bold>Background:</ns3:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
<ns4:p><ns4:bold>Background:</ns4:bold> Antibody responses have been used to characterise transmission and exposure history in malaria-endemic settings for over a decade. Such studies typically conducted on well-standardised enzyme-linked immunosorbent assays (ELISAs). However, recently developed quantitative suspension array technologies (qSAT) are now capable of high-throughput multiplexed screening up hundreds analytes at time. This study presents customised protocol the Luminex...
The majority of malaria infections in low transmission settings remain undetectable by conventional diagnostics. A powerful model to identify antibody responses that allow accurate detection recent exposure low-density is controlled human infection (CHMI) studies which healthy volunteers are infected with the Plasmodium parasite. We aimed evaluate malaria-naïve exposed a single CHMI using custom-made protein microarray. All participants developed blood-stage peak parasite densities up 100...
As malaria transmission declines, sensitive diagnostics are needed to evaluate interventions and monitor transmission. Serological assays measuring antibody responses offer a cost-effective detection method supplement existing surveillance tools.A prospective cohort study was conducted from 2013 2015 in 12 villages across five administrative regions The Gambia. analysis included samples the West Coast Region at start end of season (July December 2013) Upper River July April 2014....
As The Gambia aims to achieve malaria elimination by 2030, serological assays are a useful surveillance tool monitor trends in incidence and evaluate community-based interventions.
During a Plasmodium infection, exposure of human host immune cells to both the asexual and sexual stages parasite elicit responses. These responses may be protective prevent development high parasitaemia its associated clinical symptoms, or block transmission malaria an uninfected person. This study aimed at examining dynamics naturally acquired against forms falciparum as well assessing differences in multiplicity infection (MOI) asymptomatic Ghanaian children living two communities with...
Abstract Malaysia has reported no indigenous cases of P. falciparum and vivax for over 3 years. When transmission reaches such low levels, it is important to understand the individuals locations where exposure risks are high, as they may be at greater risk in case a resurgence transmission. Serology useful tool settings, providing insight into longer durations than PCR or RDT. We ran blood samples from 2015 population-based survey northern Sabah, Malaysian Borneo on multiplex bead assay....
Background Antimalarial antibody measurements are useful because they reflect historical and recent exposure to malaria. As such, may provide additional information assess ongoing transmission in low endemic or pre-elimination settings where cases rare. In addition, the absence of responses certain individuals can indicate cessation transmission. Commercial malaria enzyme-linked immunosorbent assays (ELISA) detect antimalarial antibodies commonly used screen blood donations for possible...