A5004614534- Malaria Research and Control
- Mosquito-borne diseases and control
- Parasites and Host Interactions
- Vector-borne infectious diseases
- Hemoglobinopathies and Related Disorders
- Global Maternal and Child Health
- Urticaria and Related Conditions
- Helminth infection and control
- HIV Research and Treatment
- Parasite Biology and Host Interactions
- Fungal Infections and Studies
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Insect Pest Control Strategies
- Drug-Induced Hepatotoxicity and Protection
- Research on Leishmaniasis Studies
- Complement system in diseases
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Salivary Gland Disorders and Functions
- Child Nutrition and Water Access
- Trypanosoma species research and implications
- Yeasts and Rust Fungi Studies
Université des Sciences de la Santé
2024
Université de Thiès
2024
Macronix International (China)
2024
Merck (Germany)
2024
Cheikh Anta Diop University
2012-2023
University of Ghana
2018-2022
Noguchi Memorial Institute for Medical Research
2018-2022
: Background: Diversity in Plasmodium falciparum poses a major threat to malaria control and elimination interventions. This study utilized 12 polymorphic microsatellite (MS) markers the Msp2 marker examine diversity, multiplicity of infection (MOI) as well population structure parasites circulating two sites separated by about 92 km with varying transmission intensities within Greater Accra Region Ghana.The diversity MOI P. 160 non-symptomatic volunteers living Obom (high intensity)...
Despite marked progress in Senegal, three regions the southeast part continue to have a high burden of malaria, but there been no recent studies assessing prevalence malaria associated with pregnancy. This study aimed determine infection pregnant women attending antenatal clinics Senegal. During transmission season 2019, 11 health care facilities for scheduled visit and those presenting unwell signs were invited participate screening study. A finger prick blood sample was taken diagnosis by...
An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment uncomplicated Plasmodium falciparum malaria children. In each arm, 160 patients were assigned receive either AS + MQ or AL with 28 days follow-up. The adequate parasitological response at Day for per protocol analysis after polymerase chain reaction correction, 100% 96.8% AL....
In sub-Saharan Africa, malaria is the leading cause of morbidity and mortality especially in children. Senegal, seasonal chemoprevention (SMC) previously referred to as intermittent preventive treatment children (IPTc) a new strategy for control areas high transmission. An effectiveness study SMC, using sulphadoxine-pyrimethamine (SP) plus amodiaquine (AQ), was conducted central Senegal from 2008 2010 obtain information about safety, feasibility delivery, cost SMC. Here are report effect SMC...
Asymptomatic malaria infections can serve as potential reservoirs for transmission. The density of parasites contained in these range from microscopic to submicroscopic densities, making the accurate detection asymptomatic parasite carriage highly dependent on sensitivity tools used diagnosis. This study sought evaluate sensitivities a variety molecular and serological diagnostic at determining prevalence Plasmodium falciparum two communities with varying prevalence.Whole blood was collected...
Prompt treatment of malaria attacks with arteminisin-based combination therapy (ACT) is an essential tool for control. A new co-blister tablet artesunate-mefloquine (AM) 25 mg/kg mefloquine has been developed the management uncomplicated attacks. This non-inferiority randomized trial, was conducted to evaluate efficacy and safety formulation AM in comparison artemether-lumefantrine (AL) acute Plasmodium falciparum adults Senegal. The study carried out from September December 2010 two health...
Since 2006, artemisinin-based combination therapies (ACT) have been used to treat uncomplicated Plasmodium falciparum malaria in Senegal, as recommended by WHO. Recently, decreased parasite clearance with artemisinin derivatives has reported Cambodia and Thailand. The effectiveness of Africa must be monitored. This study was conducted evaluate the efficacy tolerability three ACT widely Senegal. From October 2010 February 2011, a descriptive analytical sequential adults children these...
Background Concurrent infections of Plasmodium falciparum with Soil Transmitted Helminths (STH) and Schistosoma spp are still a major public health problem among children living in Sub-Saharan Africa. We conducted two prospective studies urban rural settings Senegal, where control programmes for malaria, STH schistosomiasis have been sustained, to determine the prevalence malaria-helminth co-infection. Methods enrolled 910 aged 1–14 years from Saraya Diourbel districts Senegal June November...
Seasonal malaria chemoprevention (SMC) is defined as the intermittent administration of full treatment courses an antimalarial drug to children during peak transmission season with aim preventing malaria-associated mortality and morbidity. SMC using sulfadoxine–pyrimethamine (SP) combined amodiaquine (AQ) a promising strategy control morbidity in areas highly seasonal transmission. However, concern whether can delay natural acquisition immunity toward parasites intense delivery. To...
Antibodies against Region III-V of the erythrocyte binding antigen (EBA) 175 (EBA175RIII-V) have been suggested to provide protection from malaria in a natural infection. However, quality and quantity naturally induced antibodies EBA175RIII-V has not fully characterized different cohorts Ghanaians. This study sought determine characteristics asymptomatic adults children living two communities varying P. falciparum parasite prevalence southern Ghana.Microscopic evaluation thick thin blood...
Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living malaria-endemic countries. This study identified the prevalence malaria parasites corresponding levels naturally acquired anti-parasite antibody afebrile two communities Greater Accra Region Ghana.Two cross-sectional studies conducted January February 2016 repeated July August recruited subjects aged between 6 75 years from high parasite (Obom) low (Asutsuare) communities. Whole blood (5 ml) was...
Abstract Background: Infections caused by Plasmodium vivax are underestimated in Sub-Saharan Africa. Several cases have been reported recent years including Duffy-negative individuals. Most of the uncomplicated, however severe infections can occur with sometimes poor outcomes. Here, we report first case infection north Senegal. Case presentation: MDD, 12 old female patient aged has received at hospital for fever, abdominal pain and vomiting. The physical examination revealed a jaundice...
Abstract Background Malaria surveillance requires powerful tools and strategies to achieve malaria elimination. Rapid diagnostic tests for (RDTs) are easily deployed on a large scale helpful sources of parasite DNA. The application sensitive molecular techniques these RDTs is modern tool improving case detection drug resistance surveillance. Several studies have made it possible extract the DNA Plasmodium falciparum from RDTs. knowledge gametocyte carriage in population important better...
Background. One major issue that has set back the gains of numerous malaria control interventions national programs have implemented is asymptomatic malaria. Certain host genetic factors are known to influence symptomatic malaria; however, not much about how genetics influences acquisition Methods. Genomic DNA was extracted from whole blood collected 60 and 149 nonfebrile (asymptomatic, N = 109, uninfected, 40) volunteers aged between 2 69 years a high (Obom) low (Asutsuare) transmission...
Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for development an integrated control strategy that may help achieve elimination helminths. We conducted randomised, controlled, observer-blind trial assess feasibility safety combining mass drug administration (MDA) schistosomiasis soil transmitted (STH) with seasonal chemoprevention (SMC) among children living Senegal. Methods Female male aged 1–14 years were...
Abstract Background The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for development an integrated control strategy that may help achieve elimination helminths. A randomized, controlled, observer-blind trial was conducted assess feasibility safety combining mass drug administration (MDA) schistosomiasis soil transmitted (STH) with seasonal chemoprevention (SMC) among children living Senegal. Methods Female male aged 1–14 years were...
Background Despite several interventions through malaria control programmes, asymptomatic is a major barrier to as individuals serve reservoirs from which others are re-infected. The mechanism by these remain not well understood. Much work has been done in relation human genes and their association severe, mild uncomplicated malaria. However, there limited knowledge regarding host genetic factors Method In this study, we investigated the between polymorphisms of glucose-6-phosphate...
Abstract Background: Malaria surveillance requires powerful tools and strategies to achieve malaria elimination. Rapid diagnostic tests for (RDTs) are easily deployed on a large scale helpful sources the parasite's DNA. The application of sensitive molecular techniques these RDTs is modern tool improving case detection drug resistance surveillance. However, parasite with RDT based has so far only concerned asexual forms P. falciparum. knowledge gametocyte carriage in population important...
Abstract Background: Malaria surveillance requires powerful tools and strategies to achieve malaria elimination. Rapid diagnostic tests for (RDTs) are easily deployed on a large scale helpful sources the parasite's DNA. The application of sensitive molecular techniques these RDTs is modern tool improving case detection drug resistance surveillance. Several studies have made it possible extract DNA P. falciparum RDTs. knowledge gametocyte carriage in population important better assess level...