A5015027008- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Zoonotic diseases and public health
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Clinical Laboratory Practices and Quality Control
- Iron Metabolism and Disorders
- Respiratory viral infections research
- Customer Service Quality and Loyalty
- Salmonella and Campylobacter epidemiology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Infective Endocarditis Diagnosis and Management
- Listeria monocytogenes in Food Safety
- Metabolomics and Mass Spectrometry Studies
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Vibrio bacteria research studies
- Digital Imaging for Blood Diseases
- Drug-Induced Hepatotoxicity and Protection
- Malaria Research and Control
London School of Hygiene & Tropical Medicine
2021-2024
University of London
2023
Sierra Leone Urban Research Centre
2023
MRC Unit the Gambia
2015-2021
Medical Research Council
2015-2021
Background:Staphylococcus aureus is a major human pathogen. Panton-Valentine leukocidin (PVL) virulence factor produced by some strains that causes leukocyte lysis and tissue necrosis. PVL-associated S. (PVL-SA) predominantly skin soft-tissue infections (SSTIs) but can also cause invasive such as necrotizing pneumonia. It carried both community-associated methicillin susceptible (CA-MSSA) resistant (CA-MRSA). This study aims to determine the prevalence of PVL-SA among patients seen at an...
BackgroundChildren account for a substantial proportion of cases and deaths during Ebola virus disease outbreaks. We aimed to evaluate the safety immunogenicity booster dose Ad26.ZEBOV vaccine in children who had been vaccinated with two-dose regimen comprising as one MVA-BN-Filo two.MethodsWe conducted an open-label, non-randomised, phase 2 trial at clinic Kambia Town, Sierra Leone. Healthy children, excluding pregnant or breastfeeding girls, received previous study, were aged 1–11 years...
Introduction This study aimed to determine whether the COVID-19 pandemic had an impact on essential primary healthcare services at public facilities. Methods The number of weekly consultations for antenatal care (ANC), outpatient (OPD), immunisations (EPI), family planning (FP) and HIV services, between January 2018 December 2020, were collected from 25 facilities in Masaka district, Uganda, 21 Goma, 29 Kambia Sierra Leone. Negative binomial regression models accounting clustering season...
Background. There are large data gaps in the epidemiology of diseases caused by Salmonella enterica West Africa. Regional surveillance infections is necessary, especially with emergence and spread multidrug-resistant clones. Methods. Data on isolated from various clinical specimens patients across The Gambia were collected analyzed retrospectively 2005 to April 2015. Antibiotic sensitivity testing isolates was performed disk diffusion method. Serotyping serogrouping using standard...
Invasive bacterial diseases cause significant disease and death in sub-Saharan Africa. Several are vaccine preventable, although the impact of new vaccines policies on patterns these communities is poorly understood owing to limited surveillance data.We conducted a hospital-based invasive The Gambia where blood cerebrospinal fluid (CSF) samples hospitalized participants were processed. Three periods defined relation introduction pneumococcal conjugate (PCVs), before (2005- 2009), during...
BackgroundThis study assessed the safety and immunogenicity of Ad26.ZEBOV MVA-BN-Filo Ebola virus (EBOV) vaccine regimen in infants aged 4–11 months Guinea Sierra Leone.MethodsIn this phase 2, randomised, double-blind, active-controlled trial, we randomly assigned healthy (1:1 a sentinel cohort, 5:2 for remaining via an interactive web response system) to receive followed by (Ebola group) or two doses meningococcal quadrivalent conjugate (control administered 56 days apart. Infants were...
Patients' satisfaction remains an important tool for evaluating quality of care in the emerging global trend patient-centered care.To assess with received by patients at public secondary hospitals Abuja, north central Nigeria.We measured patients' using structured questionnaire, and Cronbach α was used to consistency item responses. A multivariate mixed-effects linear regression fitted identify factors influencing overall satisfaction.All domains tested were scored "intermediate-positive...
Molecular epidemiological data on Group A Streptococcus (GAS) infection in Africa is scarce. We characterized the emm-types and emm-clusters of 433 stored clinical GAS isolates from The Gambia collected between 2004 2018. To reduce potential for strain mistyping, we used a newly published primer emm-typing. There was considerable diversity, highlighting need vaccine development offering broad protection.
Malaria infection affects the immune response to some vaccines. As Ebola virus (EBOV) outbreaks have occurred mainly in malaria-endemic countries, we assessed whether asymptomatic malaria responses 2-dose Ad26.ZEBOV, MVA-BN-Filo vaccine regimen.In this sub-study of EBOVAC-Salone trial Sierra Leone, microscopy was performed at time vaccination. Participants with symptomatic were treated before post-dose 1 (day 57) and 2 78) by EBOV glycoprotein FANG enzyme-linked immunosorbent assay (ELISA),...
Introduction Recurrent parasitic infections may influence the immune response to vaccines. In Partnership for Research on Ebola VACcinations extended follow-UP and clinical research capacity build-UP (PREVAC-UP) study being undertaken in Mambolo, northern Sierra Leone, participants are followed up assess potential impact of exposure malaria and/or helminth long-term two To support development assays that will be used this evaluation, a parasitological survey was conducted Mambolo between...
ObjectivesWe assessed the prevalence of immunoglobulin G (IgG) and IgM against four endemic human coronaviruses two SARS-CoV-2 antigens among vaccinated unvaccinated staff at health care centers in Uganda, Sierra Leone, Democratic Republic Congo.MethodsThe government facility who had patient contact Goma (Democratic Congo), Kambia District (Sierra Leone), Masaka (Uganda) were enrolled. Questionnaires blood samples collected three time points over 4 months. Blood analyzed with Luminex...
Abstract Objectives We assessed the prevalence of immunoglobulin G (IgG) and M (IgM) against four endemic human coronaviruses (HCoVs) two SARS-CoV-2 antigens, among vaccinated unvaccinated staff at health care centres in Uganda, Sierra Leone, Democratic Republic Congo (DRC). Methods Government facility who had patient contact Goma (DRC), Kambia District (Sierra Leone), Masaka (Uganda) were enrolled. Questionnaires blood samples collected three timepoints over months. Blood analysed with...
We assessed whether the immunogenicity of two-dose Ad26.ZEBOV, MVA-BN-Filo Ebola vaccine regimen with a 56-day interval between doses was affected by exposure to malaria before dose 1 vaccination and clinical episodes in period immediately after 2 vaccinations. Previous participants an trial Sierra Leone (ClinicalTrials.gov: NCT02509494) classified as low, intermediate, high according their antibody responses panel Plasmodium falciparum antigens detected using Luminex MAGPIX platform....
Pyronaridine-artesunate (PA) is a registered artemisinin-based combination therapy, potentially useful for mass drug administration campaigns. However, further data are needed to evaluate its efficacy, safety and tolerability as full or incomplete treatment in asymptomatic Plasmodium falciparum-infected individuals.This phase II, multi-center, open label, randomized clinical trial was conducted The Gambia Zambia. Participants with microscopically confirmed P. falciparum infection were...
This Commentary is aimed at examining the current attitude of healthcare providers towards pathogenic fungi, with more emphasis on The Gambia setting, and to make recommendations for better infectious disease diagnosis management.It a known fact that fungi are important diseases causative agents, clinicians however hardly request medical mycology laboratory tests either because they choose treat empirically or due lack competent laboratories around.Various literature reviewed shows some...
Full Blood Count (FBC) is a significant laboratory investigation often requested in clinical care and trials; laboratories should have comparable alternative methods for this test to ensure uninterrupted services. This study evaluated what extent the Abbott CELL-DYN Ruby Boule Medonic M-series haematology analysers can be used interchangeably.
Abstract Introduction Sodium fluoride/potassium oxalate (NaF/KOx) tubes were once regarded as the gold-standard for glucose analysis. Even though their ineffectiveness in immediately inhibiting glycolysis has been reported several studies especially first 1–4hours, they are still used our clinical Biochemistry laboratory measurement. However its absence, only SSTs employed Aim To determine whether can replace NaF/KOx laboratory-based measurement of blood and to assess stability...
Abstract Objective The objective of this study is to determine the prevalence iron deficiency (ID) and anaemia (IDA) as well general in male blood donors their association with ageing process. Methodology Results A total two hundred one (201) serum samples were analysed for ferritin Gambian donors. measurement was achieved COBAS® INTEGRA 400 plus. At same time, haemoglobin values retrospectively obtained from archived haematological full count result GARIS database. IDA defined (Haemoglobin...