A5012000373- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Clinical Laboratory Practices and Quality Control
- Blood groups and transfusion
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Scientific Measurement and Uncertainty Evaluation
- PARP inhibition in cancer therapy
- Metabolomics and Mass Spectrometry Studies
- Pneumonia and Respiratory Infections
- DNA Repair Mechanisms
- Climate Change and Health Impacts
- Blood donation and transfusion practices
- COVID-19 diagnosis using AI
- Tuberculosis Research and Epidemiology
- Digital Imaging for Blood Diseases
- CRISPR and Genetic Engineering
- Blood properties and coagulation
- Diabetes Management and Research
- Healthcare cost, quality, practices
University of Ghana
2024
MRC Unit the Gambia
2023-2024
Medical Research Council
2021-2024
London School of Hygiene & Tropical Medicine
2021-2024
Kingston University
2021
Sodium fluoride/potassium oxalate (NaF/KOx) tubes has been regarded as the gold-standard for glucose analysis. Even though their ineffectiveness in immediately inhibiting glycolysis reported several studies especially first 1-4h, they are still used our clinical biochemistry laboratory measurement. However, its absence, only serum separator employed We aim to determine whether (SSTs) can replace NaF/KOx measurement of blood and assess stability concentrations 3 days period.
<title>Abstract</title> <bold>Background/Objective</bold> assess measurement uncertainty (MU) of enumerating main haematological indices using Sysmex XN-1500 analyser and flagging performance characteristics the analyser. <bold>Methods</bold> We calculated standard MU from each possible sources error to obtain expanded at a 95% level confidence. employed European Federation Clinical Chemistry Laboratory Medicine (EFLM) Milan model biological variation EFLM database verify that our values...
The objectives of this study were to determine the presence and effect seasonal variations provide insights into trend from 2018 2022 in a comprehensive set routine haematological indices biochemical measurements Gambian adults with no known underlying health condition. We retrieved five years data an electronic database analysed 493 full blood counts 643 different individuals. In study, we focused on individuals condition who visited clinical diagnostic laboratory for medical examinations...
The aim of this study was to determine the prevalence invasive bacterial infections and their antimicrobial resistance patterns in sickle cell disease (SCD) patients admitted at Medical Research Council Gambia (MRCG) Ward era PCV Hib vaccination Gambia.This conducted clinical laboratory department MRCG. We retrospectively generated haematological, blood culture data from our electronic medical records 2015 2022 SCD MRCG Ward. Of 380 patients, requested only for 159. 159 SCD, 11 had qualified...
Abstract Introduction Sodium fluoride/potassium oxalate (NaF/KOx) tubes were once regarded as the gold-standard for glucose analysis. Even though their ineffectiveness in immediately inhibiting glycolysis has been reported several studies especially first 1–4hours, they are still used our clinical Biochemistry laboratory measurement. However its absence, only SSTs employed Aim To determine whether can replace NaF/KOx laboratory-based measurement of blood and to assess stability...
Abstract Background: The aim of this study was to determine the prevalence invasive bacterial infections and their antimicrobial susceptibility patterns in sickle cell disease (SCD) patients admitted at Medical Research Council Gambia (MRCG) Ward era PCV Hib vaccination Gambia. Methods Results: This conducted clinical laboratory department MRCG. We retrospectively generated haematological, blood culture data from our electronic medical records 2015 2022 SCD MRCG Ward. Of 380 patients,...
Topic: 26. Sickle cell disease Background: Invasive bacterial infections especially those caused by Streptococcus pneumoniae, Haemophilus influenzae type b, and non-typhi Salmonella species have been predominant cause of morbidity mortality in sickle (SCD) patients (Williams et al. 2009). The Gambia has a well robust vaccination programme with the introduction 7-valent pneumococcal conjugate vaccine (PCV7) 2009 then 13-valent PCV 2011. Prior to PCV, b (Hib) was introduced 1997 (Grant...
Abstract Introduction Modern haematology analysers provide an easy approach for enumerating the cellular components of blood in automated manner with improved turn-around-time. In our laboratory, we have existing full count analyser, Sysmex XN-1500. We recently bought a backup analyser from Abbott Diagnostic, Cell Dyn Emerald 22 AL that enumerates using relatively similar measuring principles. As part method verification procedure required by ISO15189, compared newly purchased to verified...
Abstract Objective The objective of this study is to determine the prevalence iron deficiency (ID) and anaemia (IDA) as well general in male blood donors their association with ageing process. Methodology Results A total two hundred one (201) serum samples were analysed for ferritin Gambian donors. measurement was achieved COBAS® INTEGRA 400 plus. At same time, haemoglobin values retrospectively obtained from archived haematological full count result GARIS database. IDA defined (Haemoglobin...
Abstract Background Homologous recombination (HR) pathway is a DNA double-stranded breaks repair well-known for its high level of accuracy. Low HR efficiency clinically known as homologous deficiency (HRD) was identified in some cancers such breast and ovarian studies have reported the sensitivity HRD cancer cells to inhibitors Olaparib. However, current techniques including immunofluorescence-based technique are qualitative-based, hence lack determine functionality pathway. Additionally,...