Angus de Wilton
A5014063247- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Single-cell and spatial transcriptomics
- Respiratory viral infections research
- COVID-19 and Mental Health
- Immune responses and vaccinations
- COVID-19 and healthcare impacts
- Amoebic Infections and Treatments
- Inflammasome and immune disorders
- Poxvirus research and outbreaks
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Bacillus and Francisella bacterial research
- Advanced Chemical Sensor Technologies
- Virology and Viral Diseases
- SARS-CoV-2 detection and testing
- Vitamin C and Antioxidants Research
- Pediatric health and respiratory diseases
- Parasitic infections in humans and animals
- Bacterial Identification and Susceptibility Testing
- Parasite Biology and Host Interactions
- Biosensors and Analytical Detection
University College London Hospitals NHS Foundation Trust
2020-2024
University College London
2020-2024
Hospital for Tropical Diseases
2020-2024
University College Hospital
2021
Royal London Hospital
2020-2021
Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T B lymphocyte antigen receptor analyses over 780,000 peripheral mononuclear from a cross-sectional cohort 130 patients with varying severities COVID-19. identified expansion nonclassical monocytes expressing complement transcripts (CD16
It is not fully understood why COVID-19 typically milder in children
A rapid, accurate, non-invasive diagnostic screen is needed to identify people with SARS-CoV-2 infection. We investigated whether organic semi-conducting (OSC) sensors and trained dogs could distinguish between infected asymptomatic or mild symptoms, uninfected individuals, the impact of screening at ports-of-entry.Odour samples were collected from adults, infection status confirmed using RT-PCR. OSC captured volatile compound (VOC) profile odour samples. Trained tested in a double-blind...
Abstract The COVID-19 pandemic, caused by SARS coronavirus 2 (SARS-CoV-2), has resulted in excess morbidity and mortality as well economic decline. To characterise the systemic host immune response to SARS-CoV-2, we performed single-cell RNA-sequencing coupled with analysis of cell surface proteins, providing molecular profiling over 800,000 peripheral blood mononuclear cells from a cohort 130 patients COVID-19. Our cohort, three UK centres, spans spectrum clinical presentations disease...
Background Neuroschistosomiasis is a severe complication of schistosomiasis, triggered by the local immune reaction to egg deposition, with spinal cord involvement most well recognised form. Early treatment praziquantel and high dose steroids leads reduction neurological sequelae. The rarity this condition in returning travellers income countries can result delayed diagnosis treatment. We aimed evaluate management neuroschistosomiasis UK national referral centre. Materials/Methods A...
Abstract While a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. Therefore, understanding differences in the local and systemic response infection between may provide important clues about pathogenesis infection. To address this, we first generated healthy reference multi-omics single cell data set from (n=30) whom have profiled triple matched samples: nasal tracheal brushings PBMCs, where track...
Abstract Background To report on the implementation and outcomes of a virtual ward established for management mpox during 2022 outbreak, we conducted 2-center, observational, cross-sectional study over 3-month period. Methods All patients aged ≥17 years with laboratory polymerase chain reaction–confirmed monkeypox virus managed between 14 May 15 August 2022, at Hospital Tropical Diseases University College London Hospitals National Health Service (NHS) Foundation Trust sexual health services...
Objectives To describe a cohort of self-isolating healthcare workers (HCWs) with presumed COVID-19. Design A cross-sectional, single-centre study. Setting large, teaching hospital based in Central London tertiary infection services. Participants 236 HCWs completed survey distributed by internal staff email bulletin. 167 were women and 65 men. Measures Information on symptomatology, exposures health-seeking behaviour collected from participants self-report. Results The respondents reported...
<h3>Introduction and Objectives</h3> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current disease 2019 (COVID-19) pandemic. Whilst a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest complications. However, underlying mechanism behind this disparity remains largely unknown. Understanding differences in local systemic response infection at single cell resolution between may offer key...
Infective endocarditis caused by Proteus mirabilis is strikingly rare. Here, we describe the case of an 86-year old man with five recurrent septic episodes over a period three months associated bacteraemia secondary to underlying endocarditis. The final diagnosis was made based on clinical findings, blood culture results and transoesophageal echocardiogram. patient treated medically 6 weeks ceftriaxone long-term oral ciprofloxacin. On completion intravenous therapy remained well. We...
<b>Background:</b> Children typically present with milder coronavirus disease 2019 (COVID-19) severity compared to adults. The molecular basis of the differences in COVID-19 progression between children and adults remains be elucidated. Here we investigated age-specific airway mucosal immunology as well systemic immune responses severe acute respiratory syndrome 2 (SARS-CoV-2) infection. <b>Methods:</b> We analysed matched nasal, tracheal blood samples from healthy patients infancy adulthood...
ABSTRACT Objectives To describe a cohort of self-isolating healthcare workers (HCWs) with presumed COVID-19. Design A cross-sectional, single-centre study. Setting large, teaching hospital based in Central London tertiary infection services. Participants 236 HCWs completed survey distributed by internal staff email bulletin. 167 were female and 65 Measures Information on symptomatology, exposures health-seeking behaviour collected from participants self-report. Results The respondents...