A5070649039- Ocular Infections and Treatments
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Immune Response and Inflammation
- Cancer Research and Treatments
- Probiotics and Fermented Foods
- Immunodeficiency and Autoimmune Disorders
- Biochemical and Structural Characterization
University of Pittsburgh
2021-2025
Commensals shape host physiology through molecular crosstalk with receptors. Identifying specific microbial factors that causally influence immunity is key to understanding homeostasis at the host-microbe interface and advancing microbial-based therapeutics. Here, we identify trehalose monocorynomycolate (TMCM) from Corynebacterium mastitidis ( C. mast ) as a potent stimulator of IL-17 production by γδ T cells ocular surface. Mechanistically, TMCM-driven responses require both IL-1 signals...
Introduction Microbiome research has grown exponentially, but the ocular surface microbiome (OSM) remains an area in need of further study. This review aims to explore its complexity, disease-related microbial changes, and immune interactions, highlights potential for manipulation as a therapeutic diseases.
Corynebacterium spp. are Gram-positive bacteria commonly associated with the ocular surface. mastitidis was isolated from mouse eyes and demonstrated to induce a beneficial immune response that can protect eye pathogenic infection. Because eye-relevant not well described, we generated C. mast transposon (Tn) mutant library gain better understanding of nature eye-colonizing bacteria.
<title>Abstract</title> Microbes exist at and colonize mucosal surfaces striking a balance with the host immune system, so that these microbes can thrive on tissues without causing pathology. Because of this, barrier-colonizing bacteria be leveraged to act as long-term delivery vehicles for naturally derived therapeutics. Here, we use mouse model corneal wound healing show eye-colonizing bacterium, Corynebacterium mastitidis (C. mast) engineered produce secrete bioactive murine...
Abstract Recently, our lab discovered that the eye harbors a microbiome includes Corynebacterium mastitidis, which induces recruitment of gdT cells and production interleukin 17 (IL-17). This local immune response to C. mast can protect from more serious infections, such as Candida albicans Pseudomonas aeruginosa. Because mast’s ability stably colonize ocular surface while inducing beneficial response, we believe this bacterium has potential act natural vehicle deliver therapeutics locally...