A5011552204- Cardiac electrophysiology and arrhythmias
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion channel regulation and function
- Animal testing and alternatives
- Genital Health and Disease
- Pharmaceutical studies and practices
- Computational Drug Discovery Methods
- Cardiac Arrhythmias and Treatments
- Female Genital Mutilation/Cutting Issues
- Urological Disorders and Treatments
- Neuroscience and Neural Engineering
- Pharmaceutical Economics and Policy
- Drug-Induced Hepatotoxicity and Protection
- Ethics and Legal Issues in Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Liver physiology and pathology
- Erythropoietin and Anemia Treatment
- Species Distribution and Climate Change
- Autoimmune and Inflammatory Disorders Research
- Liver Disease and Transplantation
- Receptor Mechanisms and Signaling
- Pharmacovigilance and Adverse Drug Reactions
- Pancreatic function and diabetes
Seattle Children's Hospital
2024
University of Washington
2024
Sexual Health Clinic
2023
The National Trust
2022
Loughborough University
1995-2020
Otsuka (United Kingdom)
2020
Harvard University
2018
Boston Children's Hospital
2018
Bureau of Land Management
2018
Learning Partnership
2017
Cognitive impairment occurs in 40–90% of patients with systemic lupus erythematosus (SLE), which is characterized by autoantibodies to nuclear antigens, especially DNA. We discovered that a subset anti-DNA antibodies, termed DNRAbs, cross reacts the N-methyl-d-aspartate receptor (NMDAR) and enhances NMDAR signaling. In patients, DNRAb presence associates spatial memory impairment. mouse model, DNRAb-mediated brain pathology proceeds through an acute phase excitotoxic neuron loss, followed...
To assess current practice in the pharmaceutical industry for assessing potential QT interval prolongation by non-cardiovascular medicinal products.The survey was based on responses from Toxicology and (Safety) Pharmacology laboratories (a total of 74 laboratories) 54 companies Europe, Japan/Asia USA, received between January March 1999.All conducted preclinical vivo electrocardiography (EGG) evaluation new active substances (NASs). Thirty these also vitro cardiac electrophysiology studies...
The rabbit isolated Langendorff heart model (SCREENIT) was used to investigate the proarrhythmic potential of a range marketed drugs or intended for market. These data were validate SCREENIT against clinical outcomes.
Furan is a potent cholangiocarcinogen in rat by an as yet undefined mechanism. The risk to man remains unclear. Using time-course stop study design, we have investigated the potential of furan induce oxidative stress and DNA damage associated with inflammatory regenerative responses liver. was administered via oral gavage (30 mg/kg b.w. 5 daily doses per week), livers were analyzed at time points between eight hr three months. A one-month recovery group previously treated for months also...
Amid growing bioethical and human rights concerns over non-therapeutic infant male circumcision, calls have been made to investigate long-term impacts on the men these infants eventually become. The present inquiry attempts identify factors contributing of claiming dissatisfaction with or ascribing harm from neonatal circumcision. This large sample size survey involved an online questionnaire opportunities upload photographic evidence. Respondents revealed wide-ranging unhealthy outcomes...
Aims This first‐in‐human clinical trial of P218, a novel dihydrofolate reductase inhibitor antimalarial candidate, assessed safety, tolerability, pharmacokinetics and food effects in healthy subjects. Methods The study consisted two parts. Part A was double‐blind, randomized, placebo‐controlled, parallel group, ascending dose comprising seven fasted cohorts. Eight subjects/cohort were randomized (3:1) to receive either single oral P218 (10, 30, 100, 250, 500, 750 1000 mg) or placebo. B an...
Women are more prone to develop torsades de pointes, a rare life-threatening polymorphic ventricular tachycardia, than men during administration of medicines that have the potential block I(Kr) (rapid delayed rectifier cardiac K(+) current) and prolong QT interval. Blockade I(Kr), hypokalaemia extreme bradycardia were used evaluate whether there gender differences in repolarisation canine Purkinje fibres (PFs). Microelectrode techniques employed measure action (AP) parameters PFs from adult...
Abstract:Temperature and precipitation data from weather stations in Alaska western Canada were analyzed via universal kriging to estimate mean annual growing season temperature values on a 10 km grid Alaska. These used produce 35 eco-climatic regions 40 for the state, as well average each region. The compared with maximum normalized difference vegetation index (NDVI) produced Advanced Very High Resolution Radiometer (AVHRR) imagery. alone can not be predict distribution, but are valuable...
Knowledge of the cardiac safety emerging new drugs is an important aspect assuring expeditious advancement best candidates targeted at unmet medical needs while also clinical trial subjects or patients. Present methodologies for assessing drug‐induced torsades de pointes (TdP) are woefully inadequate in terms their specificity to select pharmaceutical agents, which human arrhythmia toxicants. Thus, critical challenge industry today identify experimental models, composite strategies,...
Renal damage is a major side effect of the macrolide immunosuppressant FK 506. Although little known about underlying mechanism 506 nephrotoxicity, available data suggest that it may be associated with disturbance in renal hemodynamics, possibly brought by alterations production vasoactive substances such as endothelin-1 (ET-1). We have investigated release ET-1 from primary mesangial cells culture. Mesangial derived rat cortex were exposed to range concentrations (10(-10) 10(-6) M) or...
As the beagle dog is a commonly used preclinical species to test effects of new drugs on cardiac repolarisation and Purkinje fibres have become an established in vitro preparation assess these action potential duration (APD), main aim this study was therefore evaluate relative contribution inward (I(K1)) slow delayed (I(Ks)) rectifier K(+) currents under three different experimental conditions: (i) selective block I(K1) with BaCl(2), (ii) I(Ks) (-) chromanol 293B basal conditions (iii)...