A5037921480- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Systemic Lupus Erythematosus Research
- Dermatologic Treatments and Research
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders Research
- Diabetes and associated disorders
- Immune Response and Inflammation
- Salivary Gland Disorders and Functions
- Lipid Membrane Structure and Behavior
- Regulation of Appetite and Obesity
- Gastroesophageal reflux and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Antimicrobial Peptides and Activities
- Renal Diseases and Glomerulopathies
- Immunodeficiency and Autoimmune Disorders
- TGF-β signaling in diseases
- Voice and Speech Disorders
- Otitis Media and Relapsing Polychondritis
- Pulmonary Hypertension Research and Treatments
Nippon Medical School
2020-2021
Tokyo Women's Medical University
1968-2015
Keio University
2010-2014
Institute of Rheumatology
2013
Tokai University
2012
Hokkaido University
2012
Mitsubishi Group (Japan)
2008
Mitsubishi Chemical (Japan)
2008
Kyushu Institute of Technology
2008
Kumamoto University
2008
Objective. The aim of this study is to evaluate the clinical manifestation and prognostic factors anti-melanoma differentiation-associated gene 5 (MDA5) antibody-associated interstitial lung disease (ILD) with DM.
Objective. The aim of this study was to investigate the precise clinical characteristics and analyse association between anti-MDA5 antibody (anti-MDA5ab) titre disease status in patients with anti-MDA5ab-positive DM. Methods. Twenty-seven who presented DM were positive for anti-MDA5ab enrolled. manifestations parameters, including anti-MDA5ab, analysed. Results. complication rapidly progressive interstitial lung (RP-ILD) occurred 20 (74%) patients. frequencies fatal outcome, relapse...
Objective. PM and DM are often complicated by interstitial lung disease (ILD). In this study we aimed to evaluate various serum cytokines in patients with PM/DM ILD so as clarify the differences pathophysiology between anti-melanoma differentiation-associated gene 5 antibody-associated (anti-MDA5-ILD) anti-aminoacyl tRNA synthetase (anti-ARS-ILD). Methods. We evaluated cytokine profiles of 38 compared non-ILD subsets well anti-MDA5-ILD anti-ARS-ILD subsets. Results. The myositis...
Acute/subacute interstitial pneumonia (A/SIP) is an intractable and fatal complication of DM. Since a useful indicator predicting the A/SIP has not been found, aim this study was to determine whether serum ferritin potential predictive occurrence in 64 patients with DM.Of total enrolled, 19 had A/SIP, 24 chronic 21 were without lung disease (ILD). Clinical manifestations laboratory data obtained from medical records on admission.Serum levels extremely high DM A/SIP. It significantly higher...
The complication of interstitial lung disease (ILD) in polymyositis/dermatomyositis (PM/DM) is associated with anti-aminoacyl-transfer RNA synthetase (anti-aaRS) antibody or anti-melanoma differentiation-associated gene 5 (anti-MDA-5) positivity. Anti-MDA-5 clinically amyopathic DM and fatal outcome due to rapidly progressive ILD Asian populations. association between genetic factors anti-MDA-5 antibody-positive unclear. This study was undertaken investigate the HLA-DRB1 genotype patients...
Objective Adult‐onset Still's disease (AOSD) is a clinical entity with heterogeneous etiology. We have encountered patients AOSD who had severe polyarthritis and fulfilled the classification criteria for rheumatoid arthritis (RA); however, most typically exhibit mild arthritis. In this study, we proposed 2 subsets of investigated clinically significant characteristics subtypes. Methods retrospectively analyzed 71 consecutive AOSD. reviewed medical records all were followed up more than...
Systemic sclerosis (SSc) is an autoimmune disease for which multiple susceptibility genes have been reported. Genome-wide association studies shown that large numbers of are shared among diseases. Recently, our group identified 9 novel associated with rheumatoid arthritis (RA) in a Japanese population. The aim this study was to elucidate whether the 18 displayed associations or suggestive RA previous SSc Japanese.We performed included 415 patients and 16,891 control subjects, followed by...
To determine whether IL-18 is involved in the inflammation of DM and PM.Thirty-three patients with were enrolled this study, including 25 interstitial lung disease (ILD). In addition, 16 PM enrolled, 6 ILD. All admitted to our hospital as a result their condition requiring treatment, clinical laboratory data serum recorded on admission.Serum was significantly (P < 0.0001) higher both than healthy controls (n = 30). Serum ferritin 0.003 0.0044, respectively) patients. Additionally, 0.023...
Journal Article Serum ferritin correlates with activity of anti-MDA5 antibody-associated acute interstitial lung disease as a complication dermatomyositis Get access Takahisa Gono, Gono Institute Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-Ku, 162-0054, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasushi Kawaguchi, Kawaguchi Correspondence to: e-mail: y-kawa@ior.twmu.ac.jp Eri Ozeki, Ozeki Yuko Ota, Ota Takashi Satoh, Satoh...
Dermatomyositis (DM) is occasionally complicated by interstitial lung disease. Acute/subacute pneumonia (A/SIP) with DM intractable and life threatening. Clinically amyopathic dermatomyositis (C-ADM) also reported to be A/SIP, especially in those patients anti-melanoma differentiation-associated gene 5 (MDA5) antibody. In the present cases, we indicate that serum ferritin level correlated activity of A/SIP DM. Two patients, a 65-year-old woman 30-year-old woman, were diagnosed anti-MDA5...
Interstitial lung disease (ILD) is a serious complication of SSc. We aimed to identify markers associated with SSc-related ILD.RNA was prepared from the peripheral blood mononuclear cells 14 SSc patients, divided into four different RNA pools according presence or absence ILD and treatment, subjected microarray analysis. Real-time quantitative PCR used confirm results in 43 42 autoimmune controls 10 healthy controls. Genomic DNA samples were collected 149 patients (70 Hokkaido 79 Tokyo) who...
The objective of this study was to explore the association single nucleotide polymorphisms (SNPs) CD244 gene with several clinical features systemic lupus erythematosus (SLE). Two hundred and forty-three patients SLE 369 healthy controls were enrolled. SNPs (rs6682654 rs3766379) in determined by allelic discrimination using a specific TaqMan probe. Only SNP rs3766379 significantly associated susceptibility [P = 0.009; odds ratio (OR) 1.28; 95% confidence interval (CI) 1.04-1.57]....
Journal Article Efficacy and safety of intravenous cyclophosphamide pulse therapy with oral prednisolone in the treatment interstitial lung disease systemic sclerosis: 4-year follow-up Get access Akiko Tochimoto, Tochimoto Institute Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-Ku, 162-0054, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasushi Kawaguchi, Kawaguchi Correspondence to: Tel. +81-3-52691725; Fax +81-3-52691726 e-mail:...
C-terminus of S19 ribosomal protein (RP S19) endows the cross-linked homodimer with a dual effect on C5a receptor in leucocyte chemoattraction; agonistic monocyte receptor, and antagonistic neutrophil receptor. exhibits uniform this both cell types. We have currently prepared recombinant C5a-chimeric bearing RP (C5a/RP chimera) to be used as substitute dimer. In vitro, chimera similarly inhibited intracellular Ca(2+) mobilization neutrophils induced by dimer did. guinea pig skin, 10(-7) M...
The objective of this study was to explore the association single nucleotide polymorphisms (SNPs) CD244 gene with several clinical features systemic lupus erythematosus (SLE). Two hundred and forty-three patients SLE 369 healthy controls were enrolled. SNPs (rs6682654 rs3766379) in determined by allelic discrimination using a specific TaqMan probe. Only SNP rs3766379 significantly associated susceptibility [P = 0.009; odds ratio (OR) 1.28; 95% confidence interval (CI) 1.04–1.57]....
Interstitial lung disease (ILD) is a noteworthy condition in the treatment of systemic sclerosis (SSc) because its associated mortality and morbidity; however, efficacy various treatments for ILD has been controversial previous reports. In this study, we examined safety intravenous cyclophosphamide (IVCY) pulse therapy with prednisolone (PSL) SSc. A total 121 patients SSc were screened evaluated ILD, using high-resolution computed tomography chest, pulmonary function testing, bronchoalveolar...
<h3>Background</h3> SSc is characterized by tissue fibrosis and peripheral circulatory insufficiency. Survival of influenced the involvement PAH. HIF1α guided in a hypoxic condition works as transcription factor. stimulates activity vascular endothelial growth factor (VEGF), while ligand VEGF receptor family exhibits cell proliferation angiogenesis. Association with various ischemic diseases, such heart disease, type II diabetes or neoangiogenic like cancer has been reported. Based on these...