A5017138309- NF-κB Signaling Pathways
- Systemic Lupus Erythematosus Research
- Signaling Pathways in Disease
- Abdominal vascular conditions and treatments
- Macrophage Migration Inhibitory Factor
- Digestive system and related health
- Congenital gastrointestinal and neural anomalies
- Helicobacter pylori-related gastroenterology studies
- Endoplasmic Reticulum Stress and Disease
The University of Tokyo
2023-2024
Crohn's disease is a chronic, debilitating, inflammatory bowel disease. Here, we report critical role of phospholipase C-β3 (PLC-β3) in intestinal homeostasis. In PLC-β3-deficient mice, exposure to oral dextran sodium sulfate induced lethality and severe inflammation the small intestine. The was due PLC-β3 deficiency multiple non-hematopoietic cell types. resulted reduced Wnt/β-catenin signaling, which essential for homeostasis regeneration epithelium. regulated pathway epithelial cells...
is a negative regulator of T cell activation and one the key activators type I interferon (IFN) NFκB signaling via non-classical pathways. The upstream single nucleotide polymorphism
Click to increase image sizeClick decrease size Disclosure statementTK has received speaking fees and/or honoraria from Tanabe Mitsubishi, Kissei, Pfizer, Amgen, Chugai, Daiichi-Sankyo, Eli Lilly, Eisai, Novartis, and Janssen, grants GlaxoSmithKline. HS Bristol-Myers Squibb, Sanofi, AbbVie, GlaxoSmithKline, Gilead, Boehringer Ingelheim, Jansen, Astellas, Asahi Kasei, Taisho Pharmaceutical, AstraZeneca, Daiichi-Sankyo. KF Ono, Ayumi, Daiichi Sankyo, research Tsumura, Kasei. The other authors...