A5051465583- Inflammatory Myopathies and Dermatomyositis
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Vasculitis and related conditions
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Parkinson's Disease and Spinal Disorders
- Adolescent and Pediatric Healthcare
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Urticaria and Related Conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- IgG4-Related and Inflammatory Diseases
- Genetic Syndromes and Imprinting
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Infectious Diseases and Tuberculosis
- RNA regulation and disease
- Muscle Physiology and Disorders
- Parathyroid Disorders and Treatments
- Liver Diseases and Immunity
- Celiac Disease Research and Management
The University of Tokyo
2021-2025
National Center for Global Health and Medicine
2020-2021
RA-associated interstitial lung disease (RA-ILD) is commonly associated with acute exacerbations (ILD-AE). This study examined the clinical characteristics and risk factors of ILD-AE mortality RA-ILD.We retrospectively collected data on 165 RA-ILD patients who visited or were admitted to our hospital between January 2007 December 2019. We compared did not develop identified variables significantly ILD-AE. also admission those survived died after for was defined using previously proposed...
Abstract Objective The objective of this study was to stratify patients with MCTD, based on their immunophenotype. Methods We analysed the immunophenotype and transcriptome 24 immune cell subsets [from SLE, idiopathic inflammatory myopathy (IIM) SSc] from our functional genome database, ImmuNexUT (https://www.immunexut.org/). MCTD were stratified by employing machine-learning models, including Random Forest, trained immunophenotyping data IIM SSc patients. transcriptomes gene set variation...
We aim to investigate transcriptomic and immunophenotypic features of muscle specimens from patients with idiopathic inflammatory myopathy (IIM).
Polymyalgia rheumatica (PMR) is an inflammatory rheumatic disease characterized by stiffness and aching mainly in the shoulders, neck hip girdles. The underlying pathogenesis of PMR involves myeloid lineage activation with a high expression pattern recognition receptors. In addition, vaccination against severe acute respiratory syndrome coronavirus 2 mRNA-1273 functions as both immunogen intrinsic adjuvant. It leads to innate immunity, resulting antibody production. We herein report first...
Anti-melanoma differentiation associated gene 5 antibody (anti-MDA5 Ab)-positive dermatomyositis (DM) is a representative of rapidly progressive interstitial pneumonia. However, its association with thrombotic microangiopathy (TMA), characterized by thrombocytopenia, haemolytic anaemia, and organ dysfunction, has not been defined. This study aimed to elucidate the characteristics anti-MDA5 Ab-positive DM accompanied TMA.
Trimethoprim-sulfamethoxazole (TMP-SMX), a prophylactic agent against pneumocystis pneumonia (PCP), can cause adverse drug reactions (ADRs), particularly in patients with systemic lupus erythematosus (SLE). However, the risk factors for ADRs remain unclear. Thus, we sought to examine prevalence of TMP-SMX-related SLE and identify specific ADR development these patients.We retrospectively reviewed data from connective tissue disease (CTD) who were administered TMP-SMX as PCP prophylactic. The...
<h3>Background:</h3> Idiopathic inflammatory myopathy (IIM) includes heterogeneous phenotypes such as polymyositis (PM), dermatomyositis (DM), and antisynthetase syndrome. The underlying mechanisms of muscle damage remain poorly understood. <h3>Objectives:</h3> aim this study was to investigate the transcriptome immunophenotypic features biopsies from patients with IIM. <h3>Methods:</h3> Bulk RNA-sequencing performed on biopsy samples IIM (PM; n=9, DM; n=16, classified according Bohan Peter...
Objective In fever clinics screening coronavirus disease (COVID-19), there could be patients with life-threatening diseases that physicians should not overlook. We exploratorily investigated the final diagnosis among non-COVID-19 hospitalized who visited clinic. Methods This was a retrospective, observational, and single-centered study conducted in National Center for Global Health Medicine (NCGM), Tokyo, Japan. retrospective chart review of clinic NCGM from 11 March 2020 to 24 April 2020....
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is one of the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), which characterised by systemic small vessels vasculitis associated eosinophilia. Hypertrophic pachymeningitis (HP) an inflammatory disease in cerebral or spinal dura mater thickened. AAV other than EGPA may sometimes develop HP; however, patients rarely HP. This case myeloperoxidase-ANCA-positive that presented headache and blurred vision was...
A 43-year-old woman presented to our rheumatology clinic with a 2-month history of progressive, painful ulcerations after the appearance purpura on extensor surfaces her lower legs ([Figure 1A][1]). She also had and chilbains fingers 1B][1]) in mouth.
A 60-year-old woman with rheumatoid arthritis presented diarrhea and anorexia. Biopsy of colonic erosions showed amyloid deposits apple-green birefringence on Congo red staining, a diagnosis gastrointestinal amyloidosis was made.
A 73-year-old woman with a 10-year history of RA presented to our department hoarseness and sore throat in the context polyarthralgia. She was on MTX (6 mg/week) sarilumab (200 mg/3 weeks). Physical examination showed tenderness around cricoid cartilage, swelling bilateral proximal interphalangeal, metacarpophalangeal, wrist knee joints. Direct laryngoscopy revealed swollen piriform recess mild vocal fold oedema (Fig. 1A). CT arytenoids. To determine origin inflammation, fluorine-18...
A 32-year-old woman presented to our rheumatology clinic with a 1-month history of gradually worsening dysarthria attributable tongue tremor (Video S1), fever, malaise, malar rash (Fig), chest pain, polyarthralgia, and finger S2). Laboratory findings indicated pancytopenia, lymphopenia hypocomplementemia. The patient was positive for anti-nuclear, anti-dsDNA, anti-Sm antibodies, but negative anti-cardiolipin antibody, anti-cardiolipin/β2 glycoprotein I lupus anticoagulant. Urinalysis...
<h3>Background</h3> Systemic immune-mediated diseases vary in manifestations and pathogenesis. Currently, disease diagnoses treatments are generally based on clinical symptoms some specific serological features. Because the share pathological features, it is difficult to comprehend pathogenesis manage them appropriately. To date, a limited number of studies tried stratify such patients into subgroups using transcriptomic data molecular patterns [1]; however, included diseases, patients,...