A5034276874- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatitis Pathology and Treatment
- Immune Response and Inflammation
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Streptococcal Infections and Treatments
- Gastrointestinal motility and disorders
- Neuroendocrine Tumor Research Advances
- IL-33, ST2, and ILC Pathways
- Tracheal and airway disorders
- Phagocytosis and Immune Regulation
- Anesthesia and Sedative Agents
- Lung Cancer Diagnosis and Treatment
New Tokyo Hospital
2018-2024
Kyoto Medical Center
2024
Kure Kyosai Hospital
2021-2023
National Institute of Diabetes and Digestive and Kidney Diseases
2020
ProQuest (United States)
2020
Hudson Institute
2020
International University of Health and Welfare
2012-2018
RELX Group (Netherlands)
2018
Izumo Science Center
2015
Park University
2014
Abstract MFG-E8 (milk fat globule-epidermal growth factor 8) deficiency is strongly associated with acquisition of immune-mediated disorders due to the loss tissue homeostasis. However, comparatively little known regarding its functions in gastrointestinal tract disorders, which immune homeostasis a major concern. Herein, we report altered expression inflamed colons during acute phase murine experimental colitis and found that treatment recombinant MFG-E8, but not arginine-glycine-aspartate...
TLR4, a member of pattern recognition receptors, is the main receptor LPS. MD-2 physically associates with TLR4 on cell surface and confers LPS responsiveness. Helicobacter pylori one major virulence factors for induction gastritis. We demonstrated in this study role TLR4-dependent signaling H. pylori-associated Gastric biopsy samples collected from patients without infection four gastric cancer lines were used study. TLR-4 expression specimens was examined by using RT-PCR. Localization...
INTRODUCTION: During the coronavirus disease 2019 pandemic, whether endoscopy generates aerosols needs to be determined. METHODS: In patients undergoing upper gastrointestinal with an enclosure covering their heads, 0.3–10-μm were measured for 60 seconds before, during, and after by optical counter. Whether increased in situation without was examined. RESULTS: The analysis included 103 consecutive 90 control patients. Aerosols significantly during compared group. Body mass index burping...
Several negative regulatory mechanisms control Toll-like receptor (TLR)-mediated inflammatory responses and restore immune system balance, including the zinc-finger protein A20, a regulator of TLR signalling that inhibits nuclear factor kappa B (NF-kappaB) activity. In present study, we investigated TLR-5-mediated A20 expression its role in intestinal epithelial cells (IECs) during inflammation. HCT-15 HT-29 were stimulated with flagellin, then expressions interleukin-1 receptor-associated...
BACKGROUND Because of a rapid increase in the incidence Barrett's cancer, appropriate surveillance method for esophagus is interest. Methylene blue chromoendoscopy has been reported to be an effective and inexpensive improve biopsy epithelium. However, usefulness this short-segment cases still controversial. AIMS This study was undertaken evaluate abilities crystal violet methylene detect potentially dysplastic epithelium with columnar-appearing esophago-gastric junction. PATIENTS AND...
ABSTRACT We recently demonstrated that the pattern recognition receptors (PRRs) toll-like receptor 2 (TLR2), TLR4, and CD14 are expressed in mouse colonic epithelium a compartmentalized manner. Here we report localization of TLR5, for bacterial flagellin, its distinctive down-regulation during experimental colitis. Guts from normal BALB/c mice those with dextran sodium sulfate (DSS)-induced colitis were compared. Each gut was divided into seven segments (stomach, small intestine [three...
Summary Single immunoglobulin (Ig) interleukin-1R-related molecule (SIGIRR) is an Ig-like membrane protein critical for negative regulation of Toll-like receptor (TLR)-4-mediated signalling. We investigated SIGIRR expression and its mechanism in intestinal epithelial cells (IECs) during inflammation. Endoscopic biopsy specimens were obtained from active inactive colonic mucosa ulcerative colitis (UC) patients, then was examined using real-time polymerase chain reaction (PCR)...
The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) esophageal adenocarcinoma. developed consensus-based classification for the diagnosis superficial BE-related neoplasms using magnifying endoscopy. has three characteristics: simplified, an easily understood by incorporating diagnostic criteria early gastric cancer, including white zone demarcation line, presence modified flat...
Endoscopic retrograde cholangiopancreatography (ERCP) is a useful diagnostic and therapeutic procedure; however, ERCP occasionally causes post-ERCP pancreatitis. The administration of gabexate mesilate has been reported to be effective for the prevention pancreatitis when given during after procedure. aim present study was investigate preventive effect novel protease inhibitor ulinastatin on pancreatitis.One hundred thirty-nine patients who underwent procedure were studied. These randomly...
The majority of patients with gastroesophageal reflux disease in Japan have low-grade esophagitis, including minimal changes. A modified Los Angeles classification consisting erosive esophagitis (grades - D) and nonerosive M N) has been proposed is clinical use Japan. However, it unclear whether only undemarcated mucosal discoloration (grade M) clinically significant, since interobserver variations not investigated. aim the present study was therefore to evaluate variance diagnostic...
<h3>Objectives</h3> The mechanism of transformation to intestinal metaplasia in Barrett9s oesophagus has not been clarified. We previously reported that bile acids activate the Cdx2 promoter via nuclear factor kappa B (NF-κB) and stimulate production protein oesophageal keratinocytes, resulting intestinal-type mucin. Krüppel-like 4 (KLF4) is an important transcription development mucosa similar functions as Cdx2. In present study, we investigated direct effects on KLF4 expression well...
A unique subset of B cells expressing interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) plays an essential role in preventing inflammation autoimmunity. We investigated the presence this cell intestines its pathogenesis ileitis using SAMP1/Yit age-matched control AKR/J mice. Mononuclear were isolated from mesenteric lymph nodes (MLNs) expressions B220, CD1d, CD5, Toll-like receptor 4 (TLR4) TLR9 analysed. Purified stimulated with lipopolysaccharide (LPS) or CpG-DNA, then IL-10...
Abstract Background and Aim The incidence of esophageal adenocarcinoma (EAC) in cases with long‐segment Barrett's esophagus (BE) has not been investigated Japan. aim this study is to investigate the EAC Japanese BE prospectively. Methods This a multicenter prospective cohort investigating rate patients length at least 3 cm. Study subjects received index esophagogastroduodenoscopy time enrollment, they were instructed undergo yearly follow‐up esophagogastroduodenoscopy. Patients whom was...