A5015281353- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Metastasis and carcinoma case studies
- Microscopic Colitis
- Biliary and Gastrointestinal Fistulas
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Phagocytosis and Immune Regulation
- Immune Response and Inflammation
- Digestive system and related health
- Neuroendocrine Tumor Research Advances
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Dysphagia Assessment and Management
Kure Medical Center
2019-2024
National Hospital Organization
2019-2024
Shimane Prefectural Central Hospital
2016-2021
University Gastroenterology
2021
GTx (United States)
2021
Shimane University Hospital
2012-2019
Kanazawa University
2019
Shimane University
2010-2017
Maastricht University
2015
Matsue Red Cross Hospital
2012
The role of regulatory B cells (Bregs) producing interleukin (IL)-10 in the pathogenesis inflammatory bowel diseases remains unknown. We investigated IL-10 production from patients with and immunoregulatory functions Bregs experimental colitis mouse models. CpG DNA-induced peripheral blood isolated control subjects was examined. CD19 CD1d were used for evaluating possible cell surface markers Bregs. Colitis models severe combined immunodeficiency mice established by adoptive transfer whole...
Fecal calprotectin (FC) has emerged as a reliable surrogate marker of endoscopic remission in Crohn's disease (CD), which been mainly evaluated using ileocolonoscopy. We conducted this study to clarify the predictability FC level for predicting balloon-assisted enteroscopy (BAE) findings patients with CD and compare that conventional serological biomarkers.Patients scheduled undergo BAE were prospectively enrolled, fecal blood samples collected before procedures. used modified simple score...
The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. aim of this study was to clarify the correlation FC with severity UC patients.UC patients scheduled undergo an ileocolonoscopy were enrolled samples for measurement collected prior procedure. A Mayo endoscopic subscore (MES) determined each 5 colonic segments. To evaluate association affected mucosa as well severity, we assessed level sum MES (S-MES) segments compared...
BACKGROUND High-grade pancreatic intraepithelial neoplasia (PanIN) exhibits no mass and is not detected by any examination modalities. However, it can be diagnosed juice cytology from indirect findings. Most previous cases were based on findings of a focal stricture the main duct (MPD) caudal MPD dilatation subsequent using endoscopic retrograde cholangiopancreatography (ERCP). We experienced case high-grade PanIN with an unclear over 20-mm range, but without magnetic resonance (MRCP). CASE...
A unique subset of B cells expressing interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) plays an essential role in preventing inflammation autoimmunity. We investigated the presence this cell intestines its pathogenesis ileitis using SAMP1/Yit age-matched control AKR/J mice. Mononuclear were isolated from mesenteric lymph nodes (MLNs) expressions B220, CD1d, CD5, Toll-like receptor 4 (TLR4) TLR9 analysed. Purified stimulated with lipopolysaccharide (LPS) or CpG-DNA, then IL-10...
Apoptosis is a programmed physiological death of unwanted cells, and handling apoptotic cells (ACs) thought to have profound effects on immune-mediated disorders. However, there scant information regarding the role ACs in intestinal inflammation, which immune homeostasis major concern. To investigate this, we injected into severe combined immunodeficiency adoptive transfer model chronic colitis presence absence cotransferred whole B or regulatory cell (Breg)-depleted cells. We also syngeneic...
Abstract Background and Aim The serotonin reuptake transporter (SERT) terminates activity by removing it from interstitial space. Downregulated colonic SERT expression has been reported in irritable bowel disease (IBS), symptoms resembling IBS occur cases of inflammatory (IBD) remission; thus, a common pathogenesis for IBD is possible. However, little known regarding mucosa patients during healing. Methods Twenty‐two ulcerative colitis (UC) underwent colonoscopy examinations, which inflamed...
Although safe, colorectal endoscopic submucosal dissection (ESD) using a scissor-type knife has slow resection speed. We aimed to evaluate the efficacy of traction device hasten speed.This multicenter randomized controlled trial was conducted at 3 Japanese institutions. Patients with 20-50-mm superficial tumor were enrolled and randomly assigned conventional-ESD (C-ESD) group or traction-assisted ESD (T-ESD) group. The primary outcome speed.The C-ESD T-ESD groups comprised 49 48 patients,...
Fecal calprotectin level in ulcerative colitis patients is correlated with endoscopic findings. However, its association various disease types has not been elucidated. In the present study, we investigated correlation of fecal findings as compared to blood biomarkers according type. well biomarkers: C-reactive protein (CRP), white count (WBC), erythrocyte sedimentation rate (ESR), hemoglobin, platelet (PLT), and serum albumin (Alb) were measured who underwent a complete colonoscopy. Disease...
The oncological outcomes, especially high recurrence rate, of bridge-to-surgery (BTS) self-expandable metallic stent (SEMS) placement remain concerning, emphasizing the necessity standardized SEMS placement. However, its impact on long-term BTS outcomes is unknown. We investigated colonic stenting using
Milk fat globule-epidermal growth factor 8 (MFG-E8), a glycoprotein secreted from various cells, enhances engulfment of apoptotic cells by forming link between phosphatidylserine on and αvβ3-integrin phagocytes. This process is essential for maintaining the host immune system under physiological conditions. Apart this scavenging function, MFG-E8 also directly regulates variety cellular functions, such as attenuating inflammation healing injured tissues. Furthermore, recent studies have...
A flat, elevated lesion measuring 5 mm in diameter was found the gastric body of an 80-year-old man. biopsy showed moderately differentiated adenocarcinoma, and endoscopic ultrasonography revealed a hypoechoic mass located submucosa. Endoscopic submucosal dissection subsequently performed, pathological examination tumor composed adenocarcinoma neuroendocrine carcinoma with infiltration. The diagnosis mixed adenoneuroendocrine (MANEC). An additional gastrectomy procedure no recurrence noted...
During intestinal inflammation, a variety of signaling events are activated to perform several cell functions. Although the distinct roles these pathways have been elucidated, effects their crosstalk activities remain be clarified. We evaluated between two evolutionary conserved systems, toll-like-receptor (TLR) 5 and Notch1, in epithelial cells during inflammation. Significant induction expression Notch1 Jagged1 was observed distal part colon, together with abundant localization...