A5112498944- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Digestive system and related health
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Peroxisome Proliferator-Activated Receptors
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Microscopic Colitis
- Veterinary medicine and infectious diseases
- Immune Response and Inflammation
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Liver physiology and pathology
- Galectins and Cancer Biology
Matsue Red Cross Hospital
2022-2024
Yokohama City University
2020
Teikyo University
2018
Shimane University
2002-2012
University of Shimane
2012
Koujin Hospital
2002
Murata (Japan)
2002
Tohoku University
2000
Chugai Pharma (United States)
2000
Kyoto University
2000
Abstract Pattern recognition receptors (PRRs), which include the Toll-like (TLRs), are involved in innate immune response to infection. TLR4 is a model for TLR family and main LPS receptor. We wanted determine expression of compare it with that TLR2 CD14 along gastrointestinal mucosa normal colitic BALB/c mice. Colitis was induced 2.5% dextran sodium sulfate (DSS). Mucosa from seven segments digestive tract (stomach, small intestine three parts, colon parts) isolated by two different...
Peroxisome proliferator-activated receptor (PPAR) gamma is expressed in human colon cancer, prostate cancer and breast cells, PPARgamma activation induces growth inhibition these cells. expression gastric however, has not been fully investigated. We report the effect of ligands on proliferation carcinoma cell lines. Immunohistochemistry was used to demonstrate presence protein surgically resected specimens from well differentiated, moderately differentiated poorly adenocarcinoma. reverse...
<b>Background and aims:</b> The mechanism of transformation to intestinal metaplasia in Barrett’s oesophagus has not been clarified. We investigated the effects various bile acids on expression caudal related homeobox gene Cdx2 cultured oesophageal squamous epithelial cells. In addition, morphological histochemical changes cells were studied response acid induced Cdx2. <b>Methods:</b> A rat model was created by anastomosing jejunum, immunohistochemistry. Also, human colon cell lines Caco-2...
TLR4, a member of pattern recognition receptors, is the main receptor LPS. MD-2 physically associates with TLR4 on cell surface and confers LPS responsiveness. Helicobacter pylori one major virulence factors for induction gastritis. We demonstrated in this study role TLR4-dependent signaling H. pylori-associated Gastric biopsy samples collected from patients without infection four gastric cancer lines were used study. TLR-4 expression specimens was examined by using RT-PCR. Localization...
The prevalence of gastroesophageal reflux disease (GERD) in adults is increasing Japan as well worldwide likely due to obesity and the decreasing rate Helicobacter pylori infection. However, data regarding GERD children adolescents are lacking. We investigated children, adults, elderly living same community.We surveyed employees Shimane University Hospital a related facility their families using Gastroesophageal Reflux Disease Questionnaire (GerdQ) Izumo Scale instruments with demographic...
Fecal calprotectin (FC) has emerged as a reliable surrogate marker of endoscopic remission in Crohn's disease (CD), which been mainly evaluated using ileocolonoscopy. We conducted this study to clarify the predictability FC level for predicting balloon-assisted enteroscopy (BAE) findings patients with CD and compare that conventional serological biomarkers.Patients scheduled undergo BAE were prospectively enrolled, fecal blood samples collected before procedures. used modified simple score...
The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. aim of this study was to clarify the correlation FC with severity UC patients.UC patients scheduled undergo an ileocolonoscopy were enrolled samples for measurement collected prior procedure. A Mayo endoscopic subscore (MES) determined each 5 colonic segments. To evaluate association affected mucosa as well severity, we assessed level sum MES (S-MES) segments compared...
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been implicated in the growth inhibition and differentiation of certain human cancers with diverse tissue origin. In this study, expression PPARγ hepatocellular carcinoma (HCC) effect on HCC cells were investigated vitro using Hep G2, HuH-7, KYN-1 KYN-2 cell lines. All lines found to express functionally active a marked was induced by thiazolidinedione troglitazone, pioglitazone as well its natural ligand...
The mechanism of transformation to intestinal metaplasia in Barrett's oesophagus has not been clarified. We previously reported that bile acids activate the Cdx2 promoter via nuclear factor kappa B (NF-kappaB) and stimulate production protein oesophageal keratinocytes with a resulting type mucin. In addition Cdx2, Cdx1 may play an important role development oesophagus. Therefore, we studied direct effects on expression as well precise mechanisms cultured squamous epithelial cells....
ABSTRACT We recently demonstrated that the pattern recognition receptors (PRRs) toll-like receptor 2 (TLR2), TLR4, and CD14 are expressed in mouse colonic epithelium a compartmentalized manner. Here we report localization of TLR5, for bacterial flagellin, its distinctive down-regulation during experimental colitis. Guts from normal BALB/c mice those with dextran sodium sulfate (DSS)-induced colitis were compared. Each gut was divided into seven segments (stomach, small intestine [three...
Reg is a growth factor with mitogenic effects on pancreatic beta cells and gastric stem cells. To date, there has been no information available Reg-mediated intracellular signal transduction pathways. The role of in the carcinogenesis also unknown. In current study, signaling pathway cancer cell was examined. treatment MKN45 resulted tyrosyl-phoshorylation several cellular proteins subsequent activation classical MAPK, ERK1/2. stimulated thymidine incorporation AGS dose-dependent manner....
<h3>Objectives</h3> The mechanism of transformation to intestinal metaplasia in Barrett9s oesophagus has not been clarified. We previously reported that bile acids activate the Cdx2 promoter via nuclear factor kappa B (NF-κB) and stimulate production protein oesophageal keratinocytes, resulting intestinal-type mucin. Krüppel-like 4 (KLF4) is an important transcription development mucosa similar functions as Cdx2. In present study, we investigated direct effects on KLF4 expression well...
For the production and vesicle storage of histamine, Enterochromaffin-like (ECL) cells express histidine decarboxylase (HDC) vesicular monoamine transporter 2 (VMAT2). Although HDC VMAT2 show dynamic changes during gastric ulcer healing, control system their expression has not been fully investigated. In present study, we investigated effect transforming growth factor-alpha (TGF-alpha) proinflammatory cytokines on in rat ECL cells. Time course TGF-alpha healing acetic acid-induced ulcers...
Gastroesophageal reflux occurs mainly during the daytime in patients with Los Angeles grade A esophagitis, but predominantly night C and D esophagitis. The purpose of present paper was to investigate whether this difference pattern gastroesophageal influences circumferential localization erosions esophageal wall.The subjects were 394 consecutive diagnosed endoscopically as having esophagitis (grade A, n = 223; B, 93; C, 53; D, 25 cases). Their endoscopic films reviewed retrospectively...
Chronic inflammation induced by Helicobacter pylori infection is closely associated with epithelial cell proliferation and apoptosis, which are related to cellular turnover in gastric mucosa. Reg protein a regenerating gene product potent growth factor for mucosal cells, however, little known regarding its association the pathogenesis of H. infection. The aim this study was investigate production regulation pylori-associated gastritis.Gastric fundic biopsy samples were taken from patients...
Consensus regarding the cutoff value of fecal calprotectin (FC) for predicting histological healing (HH) in ulcerative colitis (UC) is lacking. This study aimed to determine an optimal FC HH patients with UC clinical and endoscopic remission. Furthermore, FC's predictability prolonged remission (CR) was investigated.Patients remission, defined as a partial Mayo score (PMS) ≤ 2 points subscore 0-1, were prospectively enrolled. Biopsy samples evaluated by Geboes (GS), GS < 2.0. Patients...