A5090179451- Inflammatory Bowel Disease
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Bleeding Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders
- Liver Diseases and Immunity
- Gastrointestinal Tumor Research and Treatment
- Polyamine Metabolism and Applications
- Immunodeficiency and Autoimmune Disorders
- Gut microbiota and health
- Eosinophilic Esophagitis
- Ferroptosis and cancer prognosis
- Clostridium difficile and Clostridium perfringens research
- Vascular Malformations and Hemangiomas
- Infectious Diseases and Tuberculosis
- Psoriasis: Treatment and Pathogenesis
- Cancer, Lipids, and Metabolism
- Phenothiazines and Benzothiazines Synthesis and Activities
- Circular RNAs in diseases
Kyushu University Hospital
2019-2024
Kyushu University
2013-2023
Fukuoka University
2022
Japanese Red Cross Fukuoka Hospital
2008-2021
Saiseikai Central Hospital
2014-2018
Japanese Red Cross Society, Japan
2016
Red Cross Hospital
2008
Krankenhaus vom Roten Kreuz
2008
Okayama University
1999-2006
Abstract Background and Aim The gut microbiota is suggested to play an important role in the pathogenesis of ulcerative colitis (UC). However, interindividual spatial variations hamper identification UC‐related changes. We thus investigated paired mucosa‐associated obtained from both inflamed non‐inflamed sites UC patients corresponding non‐inflammatory bowel disease (IBD) controls. Methods Mucosal biopsies were 14 with active left‐sided or proctitis type. Paired mucosal non‐IBD microbial...
Gastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant gastric neoplasia. However, the etiology, classification, and clinicopathological features epithelial neoplasm mucosa lineage (GEN-FGML; generic term GA-FG related neoplasm) are not fully elucidated. We performed large, multicenter, retrospective study to establish new classification clarify GEN-FGML.
This study was conducted to develop a simple surrogate index comprised of routinely available laboratory tests reflect the histological fibrosis stage. Clinical characteristics and data from 368 249 consecutive patients with chronic hepatitis C, training cohort validation cohort, respectively, were retrospectively evaluated. Platelet (Plt) count albumin (Alb) level contributed discrimination respective stages. We derived (FI), FI = 8.0-0.01 x Plt (10(3)/microliter) - Alb (g/dl), multiple...
microRNAs (miRNAs) have been suggested to be candidates for biomarkers in various diseases including Crohn's disease (CD). To identify possible predictive of the therapeutic effect infliximab CD, we investigated serum miRNA levels during induction therapy by medication.Nineteen CD patients who were applied enrolled. Serum samples analyses obtained at weeks 0 and 6, efficacy was assessed according activity index value week 14. Exploratory profiling low-density array initially performed three...
Lamivudine is widely used to treat patients with hepatitis B. However, the outcomes in hepatocellular carcinoma (HCC) treated lamivudine have not been established. This study was conducted evaluate of treatment for HCC using an untreated, matched control group. Thirty controlled orally received lamivudine. As controls, 40 who were and clinical features selected. The lamivudine-treated untreated groups compared respect changes liver function, recurrence, survival, cause death. In group, there...
Abstract Objectives Artificial intelligence (AI) may be practical for image classification of small bowel capsule endoscopy (CE). However, creating a functional AI model is challenging. We attempted to create dataset and an object detection CE explore modeling problems assist in reading CE. Methods extracted 18,481 images from 523 procedures performed at Kyushu University Hospital September 2014 June 2021. annotated 12,320 with 23,033 disease lesions, combined them 6161 normal as the...
Abstract Background and Aim Indigo naturalis (IN) is a traditional Chinese herbal medicine reported to be effective in inducing remission ulcerative colitis (UC). We conducted retrospective observational study investigate the efficacy safety of IN for induction maintenance therapy patients with inflammatory bowel disease. Methods Data were collected from electric medical records disease who had started treatment between March 2015 April 2017 at Kyushu University Hospital. Clinical response...
Recent studies suggested a favorable effect of indigo naturalis (IN) in inducing remission for refractory ulcerative colitis (UC), however, the maintenance IN patients with UC remains unknown. Therefore, we conducted prospective uncontrolled open-label study to analyze efficacy and safety UC.Patients moderate severe active (clinical activity index [CAI] ≥ 8) took 2 g/day 52 weeks. CAI at weeks 0, 4, 8, Mayo endoscopic subscore (MES) Geboes score (GS) were assessed. Clinical (CAI ≤ 4),...
To investigate the mucosal microbiota in stomach of patients with Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma by means metagenomic analysis.Although some gastric MALT lymphomas are associated presence H. pylori, other occur independently pylori infection. The pathogenesis remains unclear.Mucosal biopsy specimens were collected from body 33 lesions, including both pylori-infection naïve and posteradication patients, as well 27 control participants without...
An association has been found between human-gut microbiota and various diseases (e.g., metabolic disease) by analyzing fecal or colonic microbiota. Despite the importance of small intestinal microbiota, sampling difficulties prevent its full analysis. We investigated composition metagenomic functions along intestine compared them with from feces other gastrointestinal (GI) sites.Mucosal samples six GI sites (stomach, duodenum, distal jejunum, proximal ileum, terminal rectum) were collected...
Objective T helper (Th) cells play a central role in the pathogenesis of ulcerative colitis (UC). The present study analyzed changes circulating by administration ustekinumab (UST), an interleukin-12/23p40 antibody. Methods CD4 were isolated from peripheral blood at 0 and 8 weeks after UST treatment, we proportion flow cytometry. Clinical information laboratory data obtained 0, 8, 16 weeks. Patients We evaluated 13 patients with UC who received for induction remission between July 2020...
Abstract Because the pathogenesis of gastrointestinal follicular lymphoma (GI‐FL) remains unclear, no standardized treatment strategy has been established. Of lymphomas, gastric mucosa‐associated lymphoid tissue lymphomas are strongly associated with Helicobacter pylori ; hence, microbiota may be involved in GI‐FL pathogenesis. However, association between and uninvestigated. Therefore, we compared mucosal microbiotas patients those controls to identify changes patients. Mucosal biopsy...
Patients with chronic enteropathy associated SLCO2A1 (CEAS) develop multiple circular, longitudinal, or eccentric ulcers in the ileum. It is sometimes difficult to distinguish CEAS from Crohn's disease. and primary hypertrophic osteoarthropathy (PHO) are together known be caused by a mutation of gene. The case 65-year-old man whose characteristic appearance due pachydermia forehead folds led diagnosis PHO presented.
Chronic hepatitis B (CHB) leads to cirrhosis and hepatocellular carcinoma (HCC). With a cohort of 1,206 CHB patients who visited Okayama University Hospital related hospitals in 2011 2012, we compared the incidence rates HCC among grouped by age, virus (HBV) DNA, e antigen (HBeAg), treatment. HCCs were observed 115 with median observation period 1,687 days. Among aged > 35 years, HBV DNA 4 log copies/mL positive HBeAg at diagnosis (n＝184), rate was 8.4% 5 years entecavir (ETV)-treated...
Objective Flares of inflammatory bowel disease (IBD) can occur infrequently after vaccination for coronavirus 2019 (COVID-19), although the details this phenomenon are poorly understood. To clarify possibility an unfavorable response in patients with IBD, we investigated IBD-related symptoms during COVID-19 vaccination.
Although capsule endoscopy (CE) is useful to evaluate obscure gastrointestinal bleeding (OGIB), CE does not always identify the responsible lesions in patients with overt OGIB.To factors predictive of rebleeding after negative OGIB.We retrospectively analyzed clinical data 221 who underwent for OGIB. Among 120 findings, course 112 was followed-up. Clinical associated and were investigated.Rebleeding identified 37 (33.0%) during follow-up CE, 36 (32.1%) developed within 24 months CE....
Ustekinumab (UST), an antibody targeting the p40 subunit of interleukin (IL)-12 and IL-23, is effective in treating Crohn's disease (CD). To clarify mechanism UST, we investigated T-cell differentiation CD patients treated with UST.Twenty-seven active were enrolled this study. Seventeen 10 anti-tumor necrosis factor (TNF)-alpha therapy. The changes proportions subsets after these therapies analyzed by flow cytometry. Comprehensive gene expression colonic mucosa also evaluated.The frequency T...
We report on a case of jejunal cancer arising from heterotopic pancreas, as depicted by small-bowel radiography and double balloon endoscopy.
It has been documented that the serum complement activities measured by hemolytic assay (CH50) are decreased after storage of sera at a low temperature in some patients with chronic hepatitis C. However, mechanism this phenomenon not identified yet. Here, we tried to elucidate factors involved cold activation (CAC). To clarify what pathway is activated CAC, cleavage products sera. C4d increased significantly 12 h-storage temperatures 5 CAC (+) compared (-) (P < 0.01) and 3 control 0.05),...
Abstract BACKGROUND Indigo naturalis (IN) is one of the herbal medicines in Chinese medicine. Recent reports have demonstrated a strong remission induction efficacy oral IN therapy for ulcerative colitis (UC), but maintenance UC unknown. OBJECTIVES We aimed to clarify effect IN. METHODS A single-center, open-label, randomized, controlled trial was conducted from August 2017 2020. Patients with who received and at least 1 year were enrolled. endoscopically confirmed mucosal healing (Mayo...