A5027680971- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Liver Disease and Transplantation
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Viral gastroenteritis research and epidemiology
- Potassium and Related Disorders
- MicroRNA in disease regulation
- Microscopic Colitis
- Infant Nutrition and Health
- Metastasis and carcinoma case studies
- Autoimmune and Inflammatory Disorders Research
- Mycobacterium research and diagnosis
- Drug Transport and Resistance Mechanisms
- Clostridium difficile and Clostridium perfringens research
Showa General Hospital
2010-2024
Tokyo Medical and Dental University
2002-2006
Graduate School USA
2004
Pancreatic Cancer Action Network
2003
Abstract It is well known that immune responses in the intestine remain a state of controlled inflammation, suggesting not only active suppression by regulatory T cells plays an important role normal intestinal homeostasis, but also its dysregulation leads to development inflammatory bowel disease. In this study, we demonstrate CD4+CD25bright reside human lamina propria (LP) and functionally retain activities. All LP CD4+ regardless CD25 expression constitutively expressed CTLA-4,...
Abstract A newly identified costimulatory molecule, programmed death-1 (PD-1), provides a negative signal that is essential for immune homeostasis. However, it has been suggested its ligands, B7-H1 (PD-L1) and B7-dendritic cells (B7-DC; PD-L2), could also costimulate T cell proliferation cytokine secretion. Here we demonstrate the involvement of PD-1/B7-H1 B7-DC interaction in development colitis. We first examined expression profiles PD-1 ligands both human inflammatory bowel disease murine...
Abstract CD4+CD25+ regulatory T cells in normal animals are engaged the maintenance of immunological self-tolerance and prevention autoimmune disease. However, accumulating evidence suggests that a fraction peripheral CD4+CD25− cell population also possesses activity vivo. Recently, it has been shown glucocorticoid-induced TNFR family-related gene (GITR) is predominantly expressed on cells. In this study, we show CD4+GITR+ cells, regardless CD25 expression, regulate mucosal immune responses...
Gastric adenocarcinoma of fundic-gland type (GA-FG) is a rare variant gastric neoplasia. However, the etiology, classification, and clinicopathological features epithelial neoplasm mucosa lineage (GEN-FGML; generic term GA-FG related neoplasm) are not fully elucidated. We performed large, multicenter, retrospective study to establish new classification clarify GEN-FGML.
The authors have previously shown that production of interleukin (IL)-18 was increased in the inflamed mucosa patients with Crohn's disease (CD) and blockade IL-18 ameliorated murine model CD. This demonstrated plays a significant role during intestinal inflammation. However, initial inflammation unclear; therefore susceptibility transgenic (Tg) mice to acute dextran sulfate sodium (DSS)-induced colitis examined.Interleukin-18 Tg wild-type (WT) were fed 2.0% DSS for 8 days. total clinical...
SUMMARY Intestinal epithelial cell (IEC)-derived cytokines, such as stem factor (SCF), interleukin (IL)-7 and IL-15 are known to be required for the development of intestinal intraepithelial lymphocytes (IELs). A newly described cytokine, IL-18, has also been shown produced by cells. To demonstrate functional effects IL-18 on human IELs, we assessed IL-18/IL-18 receptor expression in IEC/IEL proliferation following stimulation IELs IL-18. transcripts were detected both freshly isolated...
Interaction of OX40 (CD134) on T cells with its ligand (OX40L) antigen-presenting has been implicated in pathogenic cell activation. This study was performed to explore the involvement OX40/OX40L development cell-mediated chronic colitis. We evaluated both preventive and therapeutic effects neutralizing anti-OX40L MAb colitis SCID mice induced by adoptive transfer CD4(+)CD45RB(high) as an animal model Crohn's disease. also assessed combination anti-TNF-alpha MAbs improve effect....
Several studies indicate that CD4(+) T cells, macrophages, and dendritic cells initially mediate intestinal inflammation in murine models of human inflammatory bowel disease. However, the initial role B development remains unclear. In this study we present evidence can trigger using transgenic (Tg) mice expressing CD40 ligand (CD40L) ectopically on (CD40L/B Tg). We demonstrated CD40L/B Tg spontaneously developed severe transmural both colon ileum at 8-15 wk age. contrast, TgxCD40(-/-)...
Abstract MyD88 is a key adaptor molecule for signalling via Toll‐like receptors (TLRs) and the response to gut commensal microbes. To investigate role of TLRs/MyD88 pathway in development gut‐associated lymphoid tissue (GALT), we examined Peyer's patches (PPs) cryptopatch (CP), also one effector compartment, intraepithelial lymphocyte (IEL) –/– , TLR2 TLR4 mice. In mice, organogenesis PPs was not disturbed. However, 2‐week‐old mice were significantly smaller than those +/– Also, but did...
Abstract Background: Crohn’s disease (CD) is an inflammatory bowel that associated with several changes in the immune system, including increased number of infiltrating macrophages. These macrophages release a variety pro‐inflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α) which are critically involved onset and development CD. The present study was performed to explore initial involvement T‐cell‐mediated chronic colitis. Methods: effects were evaluated saporin‐conjugated...
Abstract Background and Aims: The authors have previously shown that a third member of the CD28 family, inducible costimulator (ICOS), was increased in inflamed intestinal mucosa murine experimental colitis, blockade ICOS ameliorated development colitis. However, role rat inflammation its expression profile remains unclear. In present study, investigated involvement dextran sulfate sodium (DSS)‐induced therapeutic potential anti‐ICOS monoclonal antibody (mAb) Methods: first examined protein...
A 71-year-old man was treated for NSAIDs-induced gastric ulcer and esophagogastroduodenoscopy performed. Endoscopic findings identified a small depressed lesion─approximately 5mm in size─at the lesser curvature of antrum. Biopsy specimens showed Group 2, but using magnifying endoscopy with NBI we diagnosed lesion as cancer. ESD performed histopathological minute well-differentiated adenocarcinoma surface mucosal layer neuroendocrine carcinoma invasion to submucosal layer. The cancer detected...
Abstract Lympho‐haemopoietic progenitors residing in murine gut cryptopatches (CPs) have been shown to generate intestinal extrathymic intraepithelial lymphocytes (IELs). However, the role of CPs development inflammation remains unclear. To investigate inflammation, we examined SAMP1/Yit mice, which spontaneously develop a chronic localized terminal ileum and cecum. Here, showed sharp correlation between disease onset decreased number CPs, resulting both thymus‐independent IELs including...
A 73-year-old woman with intermittent fever and abdominal pain was referred to our hospital. Her hepatobiliary system enzymes inflammatory reaction were elevated, an enterolith of a juxtapapillary duodenal diverticulum, cholangiectasis showed on CT scan. On suspicion Lemmel syndrome, performs emergency ERCP, placed the ENBD. Cholangitis is gradually improving, replacing ENBD plastic stent 19th hospital day. 34th day, she developed vomiting pain. Although diverticulum not recognized, in small...
異所性胃腺に癌が合併することは既知の事実であるが，両者の関連性に関しては様々な報告がある。今回我々は，異所性腺管の近傍に発生した癌がその異所性腺管の上皮細胞を置換しながら粘膜下へ進展する像をとらえ，異所性胃腺に合併した癌の進展様式を知る上で示唆に富んだ症例と考えられ，報告する。