A5102755462- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Inflammatory Biomarkers in Disease Prognosis
- IL-33, ST2, and ILC Pathways
- Lung Cancer Treatments and Mutations
- Eosinophilic Disorders and Syndromes
- COVID-19 and healthcare impacts
- Diverticular Disease and Complications
- Colorectal Cancer Treatments and Studies
- Autoimmune and Inflammatory Disorders
- COVID-19 and Mental Health
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Pregnancy and Medication Impact
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Cytomegalovirus and herpesvirus research
- Tuberculosis Research and Epidemiology
- Gastrointestinal Tumor Research and Treatment
- Immunodeficiency and Autoimmune Disorders
- Stoma care and complications
Osaka Metropolitan University
2023-2025
Tokyo Metropolitan University
2023-2025
Osaka City University
2013-2022
AstraZeneca (Brazil)
2021
AstraZeneca (United Kingdom)
2020
Linkou Chang Gung Memorial Hospital
2020
Roche (United Kingdom)
2017
Objectives Neutrophil-to-lymphocyte ratio (NLR) has been used to determine the outcome in malignancies and coronary heart disease. Some reports considered value of NLR as a predictor response infliximab patients with Crohn's disease or rheumatoid arthritis; however, no similar studies have reported for ulcerative colitis (UC). This study aimed evaluate clinical significance baseline UC treated by infliximab. Materials Methods Patients moderate-to-severe active who received first infusion our...
Abstract Background The efficacy of 5-aminosalicylic acid (5-ASA) in combination with advanced therapies (ADTs), particularly ustekinumab (UST), for the treatment inflammatory bowel disease (IBD) remains unclear. Methods This retrospective cohort analysis used data from Medical Data Vision database, including patients ulcerative colitis (UC) and Crohn’s (CD) who had initiated UST therapy. Cumulative continuation rates factors associated failure were analyzed, post hoc subgroup analyses based...
Pouchitis is a common complication in patients with ulcerative colitis (UC) following colectomy ileal pouch-anal anastomosis (IPAA). Recent studies have identified novel autoantibody against integrin αvβ6 UC, correlated disease activity. This study aimed to assess the association between serum anti-integrin antibody levels and pouch inflammation postoperative UC. Serum antibodies were measured using enzyme-linked immunosorbent assay after IPAA, controls. We examined sera from 71 subjects,...
Abstract Background and Aim Tofacitinib aminosalicylic acid (5‐ASA) are commonly used to treat ulcerative colitis (UC). However, evidence on the effect of concomitant 5‐ASA use in patients receiving tofacitinib is limited. This study investigated effects combined with UC patients. Methods retrospective cohort data from Medical Data Vision database, including treated May 2018 April 2022. Patients were grouped according dosage assessed for efficacy use. The primary endpoint was clinical...
Abstract Loss-of-function mutations in the solute carrier organic anion transporter family, member 2a1 gene ( SLCO2A1 ), which encodes a prostaglandin (PG) transporter, have been identified as causes of chronic nonspecific multiple ulcers small intestine; however, underlying mechanisms not revealed. We, therefore, evaluated effects systemic knockout Slco2a1 −/− ) and conditional intestinal epithelial cells ΔIEC macrophages ΔMP mice with dextran sodium sulphate (DSS)-induced acute colitis....
Objectives: Infliximab is effective in patients with ulcerative colitis (UC); however, one-third of do not respond and require additional therapies such as other biologic agents. Therefore, the aim this study was to analyze association between pro-inflammatory molecules clinical efficacy elucidate possible mechanisms for non-response infliximab aid treatment selection.Materials method: Patients moderate-to-severe active UC receiving our hospital 2010 2016 whom pre-treatment serum samples...
Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim this study was to determine on colonic mucosa IBD assess long-term outcomes these patients. We examined mucosal specimens from 66 ulcerative colitis (UC), 54 Crohn's (CD), 29 healthy identify 6 most common types virus, using multiplex polymerase chain reaction (PCR) technique. Herpes simplex virus (HSV)-1/2 varicella-zoster...
Although tacrolimus is useful as an induction therapy in patients with ulcerative colitis (UC), information regarding the long-term outcome after insufficient. The aim of this study was to evaluate clinical significance pretreatment neutrophil-to-lymphocyte ratio (NLR) a prognostic factor UC receiving tacrolimus, aid treatment selection.Patients moderate-to-severe active who received oral and subsequent immunomodulatory maintenance at our hospital between 2009 2017 showed response week 12,...
Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker UC. This study aimed evaluate the clinical utility of NLR predicting relapse in UC MH. We retrospectively enrolled who underwent colonoscopy at Osaka City University Hospital between January 2010 December 2010, whose Mayo Subscore was 0 or 1. correlation...
Upadacitinib, a recently approved Janus kinase (JAK) inhibitor specific for JAK1, may be promising candidate in patients with ulcerative colitis (UC) who present no response or intolerance to first-line JAK inhibitors. We assessed the therapeutic impact of upadacitinib on six UC demonstrated an inadequate tofacitinib filgotinib. After 2 months treatment, 5 (83.3%) achieved clinical remission, and all experienced decreased levels CRP. One patient had coronavirus disease 2019 pneumonia showed...
Objective Balloon-assisted endoscopy enables access to and treatment of strictures in the small intestine using endoscopic balloon dilation (EBD); however, long-term outcomes EBD have not been sufficiently evaluated. This study evaluated Crohn's disease identify risk factors associated with need for subsequent surgical intervention. Methods We retrospectively analyzed patients who had undergone double-balloon (DBE) intestinal at a single center between 2006 2015. The were assessed based on...
Abstract Background and study aims Eosinophilic gastrointestinal disorders are classified into eosinophilic esophagitis, gastritis, gastroenteritis, colitis according to the site of infiltration. Although well established in endoscopic findings gastritis gastroenteritis with regard gastric lesions have not been clearly described. The aim this was identify associated disorders. Patients methods Out 278 patients disorders, 18 had or confirmed by biopsy; their images were analyzed...
Objectives Pouchitis is a major complication after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) in patients ulcerative colitis (UC). Although there have been many investigations of the neutrophil-to-lymphocyte ratio (NLR) various diseases, its role predicting development pouchitis remains unclear. We aimed to evaluate clinical utility NLR for IPAA UC patients. Materials and methods who underwent at Osaka City University Hospital between May 2006 March 2019 were...
Abstract Introduction. Both infliximab (IFX) and tacrolimus (Tac) are effective for inducing clinical remission in patients with ulcerative colitis (UC). However, no randomized study has addressed the relative efficacies of IFX Tac moderate to severe UC. This aimed conduct a retrospective on efficacy UC, using an inverse probability treatment weighting (IPTW) technique adjust background factors statistically. Methods. Between July 2009 March 2016, data obtained from 122 UC who were treated...
Background: The government of Japan declared a state emergency on April 16, 2020, owing to the coronavirus disease 2019 (COVID-19) pandemic. subsequent lockdown altered lifestyles and worsened mental illnesses. Inflammatory bowel (IBD) is an intestinal disorder that affected by environmental factors. Therefore, we aimed assess effects COVID-19 lifestyle activity patients with IBD. Methods: We conducted questionnaire survey IBD from June 16 August 21, 2020 during their regular follow-up at...
Objective To examine the effect of coronavirus disease 2019 (COVID-19) lockdown on lifestyle factors and psychological stress in patients with inflammatory bowel (IBD). Methods A retrospective study was conducted IBD Japan 2 months after initiation first state emergency (June 16 to August 21, 2020). self-reported questionnaire used collect data, levels before were compared. Patients who followed up regularly at Osaka City University Hospital from June 2020, included classified into elderly...
Coronavirus disease 2019 (COVID-19) vaccination is recommended for patients with inflammatory bowel (IBD). However, the acceptance of COVID-19 vaccines has not been sufficiently evaluated in IBD. We aimed to assess and hesitancy related factors among these patients. A retrospective cohort study using a self-reported questionnaire was performed IBD between 22 June 2021 30 August 2021. Of 187 participants, 10.2% (n = 19) were hesitant be vaccinated. Patients vaccine-hesitant group younger (p...
Ustekinumab has been proven to be effective for treatment of patients with Crohn's disease; however, 30-40% have reported lose clinical response within 2 years. We aimed evaluate the efficacy ustekinumab and identify predictors short-term long-term in disease.Patients disease receiving their first infusion our hospital between June 2017 September 2020 were prospectively enrolled. Concentrations serum cytokines chemokines measured using a multiplex bead array assay.Fifty-nine enrolled this...
Tacrolimus (Tac) is an effective remission inducer of refractory ulcerative colitis (UC). Gene polymorphisms result in interindividual variability Tac pharmacokinetics. In this study, we aimed to examine the relationships between gene and metabolism, pharmacokinetics, therapeutic effects patients with UC. Forty-five moderate-to-severe UC treated were retrospectively enrolled. Genotyping for cytochrome P450 ( CYP ) 3A4*1G , CYP3A5*3 CYP2C19*2 CYP2C19*3 nuclear receptor subfamily 1 group I...