A5024341798- Immunodeficiency and Autoimmune Disorders
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Kawasaki Disease and Coronary Complications
- Lung Cancer Treatments and Mutations
- Cardiac Structural Anomalies and Repair
- Gastrointestinal Tumor Research and Treatment
- Coronary Artery Anomalies
- Airway Management and Intubation Techniques
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Head and Neck Surgical Oncology
- Intestinal Malrotation and Obstruction Disorders
- Central Venous Catheters and Hemodialysis
- Thermal Regulation in Medicine
- Immunotherapy and Immune Responses
- Prostate Cancer Treatment and Research
- HIV Research and Treatment
- Cancer Diagnosis and Treatment
- Paraquat toxicity studies and treatments
- Connexins and lens biology
- HER2/EGFR in Cancer Research
Hiroshima University
1995-2024
Kyushu University
1992-2021
Matsuyama Red Cross Hospital
2019
Niigata Prefectural Central Hospital
2019
Tottori University
1998
University of Siena
1994
University Health Network
1993
Summary Although Kawasaki disease (KD) is characterized by a marked activation of the immune system with elevations serum proinflammatory cytokines and chemokines at acute phase, major sources for these chemical mediators remain controversial. We analysed status peripheral blood mononuclear cells (PBMCs) flow cytometry, DNA microarray quantitative reverse transcription–polymerase chain reaction. The proportions CD69+ in both natural killer γδT acute-phase KD were significantly higher than...
To investigate the mucosal microbiota in stomach of patients with Helicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma by means metagenomic analysis.Although some gastric MALT lymphomas are associated presence H. pylori, other occur independently pylori infection. The pathogenesis remains unclear.Mucosal biopsy specimens were collected from body 33 lesions, including both pylori-infection naïve and posteradication patients, as well 27 control participants without...
Summary Hyper-immunoglobulin E (IgE) syndrome (HIES) is one of the primary immunodeficiency syndromes. Although cytokine dysregulation suggested to play a role in its pathophysiology, causative gene has not yet been identified. To investigate pathophysiology and candidate genes involved this disease, we performed microarray analysis unstimulated peripheral CD4+ T cells CD14+ cells, as well blood mononuclear (PBMNC) stimulated with Staphylococcus aureus isolated from HIES patients healthy...
We describe an analysis of early B cell development in mice with X linked immunodeficiency (Xid). It was found that, compared the normal CBA/J strain, CBA/N (Xid/Xid) pre-B cells show increased proliferative response to IL-7 but a decreased ability for subsequent maturation on stromal cells. However, addition mast growth factor largely restored mature presence No anomalies were rate lg eavy or light chain gene rearrangement despite their failure undergo maturation. This suggests that these...
Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS), which is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD), a distinct disease characterized by high mortality. Treatment of patients EBV-AHS has proved challenging. To develop some therapeutic interventions for EBV-AHS, we examined the effectiveness an antiviral agent (vidarabine) chemotherapy (CHOP), using rabbit model EBV-AHS. Fourteen untreated rabbits were inoculated...
Calcineurin inhibitors (CNIs) have been used off-label for the treatment of refractory Kawasaki disease (KD). However, it remains unknown whether CNIs show protective effects against development coronary artery lesions in KD patients. To investigate on arteries and mechanisms their actions arteritis a mouse model KD, we performed experiments with FK565, ligand nucleotide-binding oligomerization domain-containing protein 1 (NOD1) wild-type, severe combined immunodeficiency (SCID),...
Objective: While there is an association between successful eradication of Helicobacter pylori (HP) and reflux esophagitis (RE), risk factors associated with RE remain obscure. The aim this study to determine the development after HP eradication.Materials methods: Among all patients treated from 2008 2016, we retrospectively analyzed those who were free at initial esophagogastroduodenoscopy (EGD) followed up EGD eradication. Patients classified according presence or absence follow-up EGD....
<title>Abstract</title> In this study, enhanced dispersion stability of cellulose nanocrystal was achieved by terminal grafting dextran (a-1,6 glucan) onto the surface nanocrystals. The 6-position carbon first oxidized TEMPO method, and introduced carboxyl group on coupled with amino terminally aminated using N-hydroxysuccinimide 1-ethyl-3-3-dimethylaminopropyl carbodiimide. Terminally obtained reductive amination sodium cyanoborohydride ammonium chloride. weight gain reached 184%...
AbstractThere is increasing evidence that cytokines are important intraovarian non-steroidal regulators. The aim of the present study was to evaluate presence in human ovary interferon (IFN)-γ, a cytokine produced by T lymphocytes after mitogenic or antigenic stimulation. Very low levels IFN-γ (0.025–0.057 IU/ml) were found follicular fluid large spontaneously maturing follicles, ovarian vein (< 0.01–0.019 peripheral blood 0.01–0.06 IU/ml). avidin-biotin immunocytochemical technique, with...
A 71-year-old man was referred to our hospital with bloody stools. Physical examination revealed normal vital signs and no abnormalities. blood test showed his hemoglobin level 9.3 g/dL. Abdominal contrast computed tomography a blind-ended structure high-density area in the lower small intestine (Fig. 1). Retrograde double-balloon endoscopy (DBE) diverticulum distal ileum 2a), an ulcer exposed vessel detected at blind end of 2b). The considered be source bleeding, we therefore performed...