A5103109962- Lung Cancer Treatments and Mutations
- Pain Mechanisms and Treatments
- Colorectal Cancer Treatments and Studies
- Neuropeptides and Animal Physiology
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Nerve injury and regeneration
- Chronic Lymphocytic Leukemia Research
- Cancer Treatment and Pharmacology
- Rheumatoid Arthritis Research and Therapies
- Erythrocyte Function and Pathophysiology
- HER2/EGFR in Cancer Research
- Immune Cell Function and Interaction
- Electric Motor Design and Analysis
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Olfactory and Sensory Function Studies
- Magnetic Bearings and Levitation Dynamics
- Immunotherapy and Immune Responses
- Retinal Diseases and Treatments
- Erosion and Abrasive Machining
- Dental Erosion and Treatment
- Oral health in cancer treatment
- Ion Channels and Receptors
Kitasato University
2025
Aichi Cancer Center
2016-2024
Niigata City General Hospital
2006-2022
Shinrakuen Hospital
2019-2022
Hyogo Medical University
2004-2022
Osaka University
2005-2022
Ogaki Municipal Hospital
2021
Niigata University
2001-2018
Niigata Cancer Center Hospital
2012-2015
Japan Tobacco (Japan)
2009
FLAURA, the prospective trial of osimertinib as a first-line therapy compared with first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), did not show superior survival benefit for in either subgroup Asians or L858R mutation. In addition, superiority second-generation EGFR-TKI is thus far unclear.We reviewed clinical data all consecutive patients who were treated afatinib between May 2016 and October 2019 from 15 institutions Japan. We defined groups based...
<b><i>Objective:</i></b> Chemotherapy with irinotecan plus cisplatin has shown promise in chemo-naïve small-cell lung cancer (SCLC) patients. However, treatment for relapsed or refractory SCLC not been adequately evaluated. This phase II study evaluated the appropriate schedule of as a single agent. was designed to determine antitumor activity, toxicity, and survival previously treated <b><i>Methods:</i></b> Previously patients at least one...
Natural killer T (NKT) cells are mainly present in the liver and thymus, majority of these express either a CD4+ or double-negative (DN) CD4–8– phenotype. In study, we examined whether such NKT were intestine. rare all sites small intestine, including an intraepithelial site. However, aconsiderable number found at site large This result was confirmed by both immunofluorescence immunohistochemistry. contrast to conventional cells, intestine CD8+ DN CD4–8–. case their existence is known depend...
Spontaneously Diabetic Torii (SDT) rat shows severe ocular complications such as tractional retinal detachment. In the present study, effect of protein kinase C beta (PKCbeta) inhibitor JTT-010 was evaluated to clarify involvement PKCbeta in SDT rat. rats were administered (10 or 50 mg/kg/day) for 48 weeks. showed delayed oscillatory potentials electroretinogram. Delayed motor nerve conduction velocity, decreased coefficients variation R-R intervals electrocardiogram and thermal hypoalgesia...
Although immune checkpoint inhibitors (ICIs) have been shown to improve overall survival (OS) in advanced non-small-cell lung cancer (NSCLC) patients, ICIs sometimes cause various types of immune-related adverse events (irAEs), which lead the interruption ICI treatment. This study aims evaluate clinical significance continuation NSCLC patients with irAEs and assess safety efficacy readministration after their discontinuation due irAEs.We retrospectively identified who were treated first-...
Activation of protein kinase C (PKC) is thought to play an important role in the pathogenesis diabetic microvascular complications. PKC-beta elevated hyperglycaemic conditions, both vivo and vitro. In this study, pharmacological effects a novel isoform selective inhibitor, JTT-010 ((2R)-3-(2-aminomethyl-2,3-dihydro-1H-3a-azacyclopenta(a)inden-8-yl)-4-phenylaminopyrrole-2,5-dione monomethanesulphonate), on neuropathy were examined.PKC inhibitory activity was evaluated with enzyme assay. For...
Background We evaluated the side effects of bisphosphonate (BP) on tooth extraction socket healing in spontaneously diabetic Torii (SDT) rats, an established model non-obese type 2 diabetes mellitus, to develop animal BP-related osteonecrosis jaws (BRONJ). Materials and Methods Male Sprague-Dawley (SD) rats SDT were randomly assigned zoledronic acid (ZOL)-treated groups (SD/ZOL or SDT/ZOL) control (SD/control SDT/control). Rats SD/ZOL SDT/ZOL received intravenous bolus injection ZOL (35...
Mouse lung tumors were induced in C57BL/6J(female) × A/J(male) F1 mice by a single s.c. injection of urethan. About 6 months later, multiple small-sized detectable almost all mice. After further months, some these became larger than the rest. We examined whether there any mutational differences among mouse. Direct DNA sequencing separately amplified Ki-ras gene polymerase chain reaction (PCR) was carried out with 25 samples from four Twenty-four (96%) had mutations at codon 61 gene. The...
This multicenter, open-label, single-arm phase II study [Niigata Lung Cancer Treatment Group (NLCTG) 1302] was conducted to evaluate the efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) monotherapy for previously treated patients with advanced non-small cell lung cancer (NSCLC). We also investigated chemotherapy-induced peripheral neuropathy (CIPN) quality life (QOL).Sixty-five NSCLC from 14 participating institutions who had undergone one or two cytotoxic...
Afatinib has shown clinical benefits in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. Many treated afatinib experience skin or gastrointestinal toxicity. However, an effective management strategy not been established. This prospective study was conducted to evaluate the efficacy of multimodal prophylactic treatment for afatinib-induced toxicity.This single-arm toxicity EGFR mutation positive advanced NSCLC who planned receive a...
The adoptive transfer of effector T cells combined with lymphodepletion has demonstrated promising antitumor effects in mice and humans, although the availability tumor-specific is limited. We others have also that polyclonal naïve induces enhances immunity after lymphodepletion. Because tumors been to induce immunosuppressive networks regulate function cells, obtaining a sufficient number fully functional are able differentiate into remains difficult. To establish culture methods obtain...
Neuronal excitability in the trigeminal sensory nuclei (TSN) changes after nerve transection. We examined effects of chronic transection on c-Fos-immunoreactivity TSN induced 2 h 10 min electrical stimulation ganglion (TG) at C-fiber activating condition (1.0 mA, 5 ms, Hz) urethane-anesthetized rats. In non-transected control rats, TG c-Fos-immunoreactive cells (c-Fos-IR cells) mostly superficial layers (VcI/II) nucleus caudalis (Vc) its full extent along dorsomedial–ventrolateral axis, but...
This study was designed to investigate the efficacy of a partial μ-opioid agonist, buprenorphine, against formalin-induced hyperalgesia in upper lip chronically inferior alveolar nerve (IAN)-transected rats. Subcutaneous injection diluted formalin into IAN-transected rats showed an increased number pain-related behavior (PRB; face-rubbing behavior) every phase up 45 min (p < 0.01) compared with that nontransected sham control The numbers c-Fos-immunoreactive (IR) cells superficial layers...