A5028682951- Gut microbiota and health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- PARP inhibition in cancer therapy
- Telomeres, Telomerase, and Senescence
- Animal Genetics and Reproduction
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Ginseng Biological Effects and Applications
- Immune Cell Function and Interaction
- Sexual Differentiation and Disorders
- Clostridium difficile and Clostridium perfringens research
- IL-33, ST2, and ILC Pathways
- Advanced Breast Cancer Therapies
- Immune cells in cancer
- Chromosomal and Genetic Variations
- Digestive system and related health
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- DNA Repair Mechanisms
- Glutathione Transferases and Polymorphisms
- Infant Nutrition and Health
- Sperm and Testicular Function
Morinaga (Japan)
2020-2024
Megmilk Snow Brand (Japan)
2024
Japanese Foundation For Cancer Research
2011-2022
Japan Science and Technology Agency
2015
Kitasato University
2006-2011
Tokyo University of Pharmacy and Life Sciences
2010
Kanazawa University
2010
Tokushima University
2010
Abstract Emerging evidence is revealing that exosomes contribute to many aspects of physiology and disease through intercellular communication. However, the biological roles exosome secretion in exosome-secreting cells have remained largely unexplored. Here we show plays a crucial role maintaining cellular homeostasis cells. The inhibition results accumulation nuclear DNA cytoplasm, thereby causing activation cytoplasmic sensing machinery. This event provokes innate immune response, leading...
In the XX/XY sex-determining system, Y-linked SRY genes of most mammals and DMY/Dmrt1bY teleost fish medaka have been characterized as that trigger formation testis. However, molecular mechanism ZZ/ZW-type system in vertebrates, including clawed frog Xenopus laevis, is unknown. Here, we isolated an X. laevis female genome-specific DM-domain gene, DM-W, obtained evidence a W-chromosome this species. The DNA-binding domain DM-W showed strikingly high identity (89%) with DMRT1, but it had no...
Obesity increases the risk of cancers, including hepatocellular carcinomas (HCC). However, precise molecular mechanisms through which obesity promotes HCC development are still unclear. Recent studies have shown that gut microbiota may influence liver diseases by transferring its metabolites and components. Here, we show hepatic translocation obesity-induced lipoteichoic acid (LTA), a Gram-positive microbial component, creating tumor-promoting microenvironment. LTA enhances...
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little currently known about whether and how causally CRC development. Here we show 12 faecal bacterial taxa enriched patients two independent cohort studies. Among them, 2 Porphyromonas species capable of inducing cellular senescence, an oncogenic stress response, through the secretion metabolite, butyrate. Notably, invasion these bacteria observed tissues, coinciding...
Long-term senescent cells exhibit a secretome termed the senescence-associated secretory phenotype (SASP). Although mechanisms of SASP factor induction have been intensively studied, release mechanism and how factors influence tumorigenesis in biological context remain unclear. In this study, using mouse model obesity-induced hepatocellular carcinoma (HCC), we identified factors, which include interleukin-1β (IL-1β)- IL-1β-dependent IL-33, from hepatic stellate (HSCs) via gasdermin D (GSDMD)...
A Y-linked gene, DMY/dmrt1bY, in teleost fish medka and a Z-linked DMRT1, chicken are both required for male sex determination. We recently isolated W-linked DM-W, as paralogue of DMRT1 Xenopus laevis, which has ZZ/ZW-type sex-determining system. The DNA-binding domain DM-W shows high sequence identity with that but no significant similarity the transactivation DMRT1. Here, we first show colocalization somatic cells surrounding primordial germ ZW gonad during next examined characteristics...
Abstract Although the p16INK4a and p21Waf1/Cip1 cyclin-dependent kinase (CDK) inhibitors are known to play key roles in cellular senescence vitro, their remain rather poorly understood vivo. This situation is partly due possibility of compensatory effect(s) between or upregulation functionally related CDK inhibitors. To directly address cooperative vivo, we generated a mouse line simply lacking both genes [double-knockout (DKO)]. Mouse embryonic fibroblasts (MEF) derived from DKO mice...
We previously investigated the gut microbiota of 453 healthy Japanese subjects aged 0 to 104 years and found that composition could be classified into some age-related clusters. In this study, we compared fecal metabolites between age-matched age-mismatched elderly examine roles in health elderly. Fecal 16 who fell an cluster (elderly-type group, E-GM) another (adult-type A-GM) were measured by CE-TOF-MS. A total eight significantly different groups: cholic acid taurocholic enriched A-GM...
A previous clinical study on pre-obesity subjects revealed that Bifidobacteriumbreve B-3 shows anti-obesity effects and possibly increases muscle mass. Here, we investigated the of function, such as strength metabolism, some signaling pathways in skeletal muscle. Male rodents were orally administered live (B-3L) or heat-killed (B-3HK) for 4 weeks. We found administration to rats tended increase mass affect with stronger B-3HK group than B-3L group. significantly increased activated Akt rat...
The molecular mechanisms of vertebrate ZZ/ZW-type sex-determining systems remain unclear. We recently indicated that a W-linked gene, <i>DM-W</i> is likely ovary-determining gene in <i>Xenopus laevis</i>. first examined whether <i>Cyp19</i> for estrogen-synthesizing enzyme P450 aromatase and <i>Foxl2</i> showed female-specific expression developing gonads. Both genes much higher ZW than ZZ gonads during after sex determination. Importantly,...
Y-linked Dmy (also called dmrt1bY) in the teleost fish medaka, W-linked Dm-W African clawed frog (Xenopus laevis), and Z-linked Dmrt1 chicken are all sex chromosome-linked homologues required for determination. both palalogues evolved through duplication, while is a orthologue. The eutherian sex-determining gene, Sry, from an allelic Sox3. Here we analyzed exon-intron structures of several vertebrate species information databases by determining transcription initiation sites chicken,...
Examining how host cells affect metabolic behaviors of probiotics is pivotal to better understand the mechanisms underlying probiotic efficacy in vivo. However, studies elucidate interaction between and cells, such as intestinal epithelial remain limited. Therefore, this study, we performed a comprehensive metabolome analysis co-culture containing Bifidobacterium breve MCC1274 induced pluripotent stem (iPS)-derived small intestinal-like cells. In co-culture, observed significant increase...
The doublesex and mab‐3 ‐related transcription factor 1 ( DMRT1 ) is involved in testis formation a variety of vertebrates. In the teleost fish, Medaka, DMY/DMRT1Y on Y chromosome, duplicate autosomal gene, characterized as sex‐determining gene. We report here characterization Xenopus genes. Reverse transcription‐polymerase chain reaction (RT‐PCR) analysis revealed that X. laevis was expressed throughout embryo during early development restricted to primordial gonads after embryogenesis....
Despite accumulating evidence that suggests a unique gut microbiota composition in athletes, comprehensive understanding of this phenomenon is lacking. Furthermore, seasonal variation the particularly during off-season, remains underexplored. This study aimed to compare microbiotas between athletic subjects (AS) and non-athletic (NS), investigate variations off-season periods. The data were derived from an observational involving Japanese male handball players. results revealed distinct AS...
Despite accumulating evidence that suggests a unique gut microbiota composition in athletes, comprehensive understanding of this phenomenon is lacking. Furthermore, seasonal variation the particularly during off-season, remains underexplored. This study aimed to compare microbiotas between athletic subjects (AS) and non-athletic (NS), investigate variations off-season periods. The data were derived from an observational involving Japanese male handball players. results revealed distinct AS...