A5010560097- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Mycobacterium research and diagnosis
- Neuroendocrine regulation and behavior
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Parathyroid Disorders and Treatments
- Stress Responses and Cortisol
- Colorectal Cancer Treatments and Studies
- T-cell and Retrovirus Studies
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Congenital Diaphragmatic Hernia Studies
- Bone health and treatments
- Law and Political Science
- Dialysis and Renal Disease Management
- Sarcoma Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Ion channel regulation and function
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2018-2023
Sophia University
2021
Kitakyushu Municipal Medical Center
2005-2019
Akashi Municipal City Hospital
2019
Sanraku Hospital
2015
Iwate Medical University
2012-2015
Keio University
2013-2015
Kitasato University
2003-2014
Juntendo University Hospital
2013
Sugiyama Jogakuen University
2012
The Ca 2 + -permeable cation channel TRPV4, which is part of the Trp family located in circumventricular organs, activated by cell swelling. To investigate role TRPV4 osmotic sensation, we disrupted gene mice and examined effect on metabolism. Disruption mouse did not influence either water intake behavior or serum osmolality. Short-term salt ingestion, however, seemed to impair transient free clearance. level arginine vasopressin (AVP) TRPV4–/– was significantly changed under normal...
The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to generation human benign and malignant tumours mesenchymal origin. However, only a few data on expression HMGA2 in tumour originating from epithelial tissue are available. In this study, we examined level pancreatic carcinoma, investigated whether alterations associated with phenotype tissue. High-mobility mRNA protein was determined eight surgically resected specimens non-neoplastic (six normal two chronic...
Abstract: In a rat phrenic nerve‐hemidiaphragm preparation, calcitonin gene‐related peptide (CGRP) increased the twitch contraction induced by nerve or transmural stimulation dose dependently. Either electrical high K + of caused release CGRP‐like immunoreactive substance (CGRP‐LIS) in Ca 2+ ‐dependent manner. Electrical also cyclic AMP content diaphragm. This increase was not observed ‐free medium and blocked antiserum against CGRP. These results indicate that excitation motor causes...
Abstract Arginine vasopressin‐ (AVP) and oxytocin‐ (OXT) secreting magnocellular neurons undergo gross structural changes with chronic physiological stimulation. Here, we investigated subcellular aspects of plasticity in rat neurohypophysial terminals during dehydration. Ultrastructural analyses demonstrated that dehydration by 2% NaCl drinking for 7 days significantly decreased the numbers neurosecretory granules microvesicles but not mitochondria. Moreover, dehydrated rats, making...
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but being applied to a wider range of neonates than originally envisaged. To examine the clinical use therapeutic hypothermia, data collected during first 3 years (2012-2014) Baby Cooling Registry Japan were analysed. Of 485 cooled neonates, 96.5% ≥36 weeks gestation 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, 96.7% required resuscitation >10 min....
Differential microsatellite instability (MSI) in tumour epithelial and stromal compartments has not been well examined for colorectal cancers. Using laser-captured microdissection, separate specimens of these 40 sporadic cancers were sampled MSI was tested with four markers. To examine the relation between phenotype stroma other genetic events histopathological features, p53 K-ras gene mutations analysed, expression p53, hMLH1, hMSH2 protein determined by immunohistochemistry. Microsatellite...
Background: Nivolumab is an immune checkpoint inhibitor that has shown efficacy for treating non-small cell lung cancer and become a standard therapy previously treated cancer. Moreover, immune-related adverse events of are well-known. Malignant pericardial effusions occasionally arise in patients with There have been few reports effusion after nivolumab administration. However, the cause this condition controversial; possibilities include serositis as event or pseudo-progression. Case...
Atezolizumab is an immune checkpoint inhibitor that a key drug in non-small-cell lung cancer treatment. However, it can cause immune-related adverse events, including liver injury. Several patterns of injury associated with therapy have been reported; however, not much known about sclerosing cholangitis. We present here case adenocarcinoma atezolizumab-induced secondary cholangitis diagnosed using needle biopsy the liver. A 77-year-old woman adenocarcinoma, cT3N2M0, stage IIIA, was treated...
An oral biofilm is a community of surface-attached microorganisms that coats the cavity, including teeth, and provides protective reservoir for microbial pathogens, which are primary cause persistent chronic infectious diseases in patients with dry mouth or Sjögren's syndrome (SS). The purpose this study was to establish an animal model studying initial adhesion streptococci formation SS attempt decrease influence cariogenic organisms their substrates. In nonobese diabetogenic (NOD) mice...
Abstract E2f1 is an important regulator of T cell proliferation, differentiation, and apoptosis that controls the transcription a group genes are normally regulated at G1 to S phase transition in cycle. Insulin-dependent diabetes mellitus (IDDM) Sjögren’s syndrome (SS) highly autoimmune diseases develop spontaneously NOD mice. The aim present vivo study was explore functional importance molecule IDDM SS, context whole animal physiology pathophysiology, using E2f1-deficient For experiment,...
Introduction/Background: Chemoradiotherapy (CRT) followed by durvalumab, an immune checkpoint inhibitor, is the standard treatment for locally advanced non-small-cell lung cancer (NSCLC). Interstitial disease (ILD) a life-threatening toxicity caused these treatments; however, risk factors ILD have not yet been established. abnormalities (ILAs) are computed tomography (CT) findings which manifest as minor interstitial shadows. We aimed to investigate whether ILAs could be grade-two or higher...
Therapeutic hypothermia following neonatal encephalopathy is neuroprotective. However, approximately one in two cooled infants still die or develop permanent neurological impairments. Further understanding of variables associated with the effectiveness cooling important to improve therapeutic regimen. To identify clinical factors short-term outcomes infants, data 509 registered Baby Cooling Registry Japan between 2012 and 2014 were evaluated. Independent death during initial hospitalization...
In ulcerative colitis (UC)-associated tumours, p53 gene mutations and protein overexpression are frequently found in early stages, but the two types of alteration do not always coincide. To clarify this discrepancy, expression p53-associated molecules were analysed UC-associated dysplasias by a combination microdissection, polymerase chain reaction-direct sequencing immunohistochemistry at single crypt level. Mismatch (+)/mutation (−) or (−)/gene mutation (+) was nine crypts regenerative...
Dental plaque is composed of a biofilm community microorganisms on teeth that coats the oral cavity, including attaching to teeth, and provides protective reservoir for microbial pathogens, which are primary cause persistent chronic infectious diseases. Oral streptococci pioneering organisms play an important role in formation tooth surfaces as well being causative agents dental caries. The purpose this study was clarify E2f1 gene susceptibility dry mouth bacterial adherence animal model...