A5018115431- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Effects of Radiation Exposure
- Esophageal and GI Pathology
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Occupational and environmental lung diseases
- Spine and Intervertebral Disc Pathology
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced X-ray and CT Imaging
- Carcinogens and Genotoxicity Assessment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Breast Lesions and Carcinomas
Hiroshima University
2016-2025
Hiroshima University Hospital
2014-2025
Tohoku University
2022
Hiroshima Prefectural Hospital
2016-2019
Rajiv Gandhi Cancer Institute and Research Centre
2019
Cancer Australia
2019
Abstract To predict grade ≥ 2 radiation pneumonitis (RP) in patients with locally advanced non-small cell lung cancer (NSCLC) using multi-region radiomics analysis. Data from 77 NSCLC who underwent definitive radiotherapy between 2008 and 2018 were analyzed. Radiomic feature extraction the whole (whole-lung analysis) imaging- dosimetric-based segmentation (multi-region performed. Patients RP or < classified. Predictors selected least absolute shrinkage selection operator logistic...
This study aimed to investigate whether vitamin K2 (menatetrenone) suppresses bone mineral density (BMD) loss in the irradiated region after radiotherapy (RT) uterine cancer patients. Our included 34 patients who underwent whole pelvic irradiation for between 2001 and 2010. The were categorized two groups: (1) Vitamin (45 mg/day) administration group (group A) with 18 cases (2) non-administered B) 16 cases. duration of was 1 year or longer. BMD measured before immediately, 3 months, 6 year,...
Introduction: To compare the efficacy and safety of stereotactic body radiation therapy with or without transcatheter arterial chemoembolization for patients small hepatocellular carcinoma who were ineligible resection ablation therapies. Methods: A total 150 185 (≤3 nodules, Child-Turcotte-Pugh class B, no vascular extrahepatic metastases) treated therapy. In principle, was combined before (combination group), but some alone. The prescribed dose 48 Gy in 4 fractions at isocenter 40 5...
This study retrospectively evaluated the long-term results of neoadjuvant chemoradiotherapy (NCRT) followed by esophagectomy for patients with resectable, locally advanced esophageal squamous cell carcinoma (ESCC). Altogether, 49 treated from 2008 to 2012 were analyzed. Chemotherapy consisted 5-fluorouracil and cisplatin. Radiotherapy was performed a total dose 40 Gy in 20 fractions primary tumor, metastatic lymph nodes, elective nodal area. Subsequently, transthoracic extensive...
Background: This study aimed to propose a machine learning model predict the local response of resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) treated by neoadjuvant chemoradiotherapy (NCRT) using pretreatment 18-fluorodeoxyglucose positron emission tomography (FDG PET) images. Methods: The responses 98 patients were categorized into two groups (complete and noncomplete response). We performed radiomics analysis five segmentations created on FDG PET images, resulting...
Abstract The effectiveness of single-fraction 8-Gy radiotherapy for painful bone metastases has been verified in numerous randomized controlled trials. However, few reports have described the tumors other than metastases. We conducted a retrospective analysis to evaluate pain response non-bone-metastasis tumors. included patients who had received such between January 2017 and December 2022, excluding those with brain metastases, hematological re-irradiation. Pain assessment was based on best...
Abstract Bone metastases are often associated with pain and can occur in various types of cancer, significantly affecting patients’ quality life. Despite the high response rates to initial conventional radiotherapy patients painful spinal metastases, recurrence inadequate still occur. Thus, development a highly effective strategy for is crucial improving life advanced metastatic cancer. This randomized phase III trial aims confirm superiority re-irradiation stereotactic body (24 Gy 2...
The purpose of this study was to evaluate the efficacy and safety volumetric modulated arc therapy (VMAT) after extrapleural pneumonectomy (EPP) in patients with malignant pleural mesothelioma (MPM). A total 15 who received VMAT EPP were enrolled. All males, median age 67 years (Stage IB two, II six, III seven patients). clinical target volume (CTV) included entire preoperative ipsilateral hemithorax involved nodal stations. CTV generally expanded by 10-15 mm beyond planning (PTV). dose...
Abstract This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and dose–volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed data 83 patients with treated using CRT 2001 2016. Furthermore, we evaluated pericardial effusion (PE) as a measure toxicity. The median total irradiation was 60 (50.4–71) Gy. Symptomatic PE observed in 12 (14%) patients. heart pericardium...
Abstract Purpose The present study aimed to evaluate the long-term results of definitive chemoradiotherapy (CRT) for unresectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). Materials and methods We analyzed eighty patients with LA-ESCC, who underwent CRT between 2001 2014. 5-year overall survival (OS), cause-specific (CSS), progression-free (PFS) rates were calculated, we investigated prognostic factors adverse events. Results median age was 66 years (range, 41–83 years)....
Introduction Cardiac toxicity after definitive chemoradiotherapy for esophageal cancer is a critical issue. To reduce irradiation doses to organs at risk, individual internal margins need be identified and minimized. The purpose of this study was quantify motion using fiducial makers based on four-dimensional computed tomography, evaluate the inter-CBCT session marker displacement breath-hold. Materials methods Sixteen patients with early stage cancer, who received endoscopy-guided metallic...
The aim of the current study is to evaluate effectiveness reduction metal artifacts using kV-CT image with single-energy based artefact (SEMAR) technique by reconstruction, monochromatic CT and rED reconstructed dual-energy reconstruction.Seven different materials (brass, aluminum, copper, stainless, steel, lead titanium) were placed inside water-based PMMA phantom. After DECT-based scan, index (AI) evaluated images without SEMAR raw-data electron density (rED), reconstruction. Moreover, AI...
Purpose: The T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign was previously reported as a diagnostic indicator of diffuse astrocytoma, isocitrate dehydrogenase-mutant, and 1p/19q noncodeletion. Subsequently, it that the same findings were observed in intrinsic pontine glioma (DIPG). We investigated clinical significance T2-FLAIR DIPG. Methods: Twenty-one patients with DIPG (Male: Female = 12:9) treated at our institute between 2004 2019. All local radiotherapy 54 Gy/30...
Introduction/Background: Chemoradiotherapy (CRT) followed by durvalumab, an immune checkpoint inhibitor, is the standard treatment for locally advanced non-small-cell lung cancer (NSCLC). Interstitial disease (ILD) a life-threatening toxicity caused these treatments; however, risk factors ILD have not yet been established. abnormalities (ILAs) are computed tomography (CT) findings which manifest as minor interstitial shadows. We aimed to investigate whether ILAs could be grade-two or higher...
It is often challenging to determine the accurate size and shape of oral lesions through computed tomography (CT) or magnetic resonance imaging (MRI) when they are very small obscured by metallic artifacts, such as dental prostheses. Intraoral ultrasonography (IUS) has been shown be beneficial in obtaining precise information about total tumor extension, well exact location guiding insertion catheters during interstitial brachytherapy. We evaluated role IUS assessing clinical outcomes...