A5028815774- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Fluorine in Organic Chemistry
- MRI in cancer diagnosis
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Acute Myeloid Leukemia Research
- Chemical Synthesis and Analysis
- Chronic Myeloid Leukemia Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Imaging and Diagnostics
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer Treatment and Pharmacology
- Xenotransplantation and immune response
- Synthetic Organic Chemistry Methods
- Eosinophilic Disorders and Syndromes
- RNA and protein synthesis mechanisms
- Ovarian cancer diagnosis and treatment
Hiroshima University
2016-2025
Hiroshima City University
2025
Okayama University Hospital
2025
The University of Tokyo
2001-2024
Kindai University Hospital
2024
Dokkyo Medical University
2006-2023
Tokyo Women's Medical University
1997-2022
University of Electro-Communications
2022
University of Tsukuba
2007-2021
Hiroshima University Hospital
2015-2021
// Mikako Ogawa 1, 7, * , Yusuke Tomita 2, Yuko Nakamura 3 Min-Jung Lee 2 Sunmin Saori Tadanobu Nagaya Kazuhide Sato Toyohiko Yamauchi 4 Hidenao Iwai Abhishek Kumar 5 Timothy Haystead 6 Hari Shroff Peter L. Choyke Jane B. Trepel Hisataka Kobayashi 1 Medical Photonics Research Center, Hamamatsu University School of Medicine, 431-3192, Japan Developmental Therapeutics Branch, Center for Cancer Research, National Institute, NIH, Bethesda, MD 20892, USA Molecular Imaging Program, Central...
CD25-targeted near-infrared photoimmunotherapy depletes T regs and promotes tumor regression.
The prognosis of cutaneous angiosarcoma (CAS), especially for patients with tumours > 5 cm has been reported to be dismal, even after conventional surgery and radiotherapy (S + RT).To demonstrate the efficacy chemoradiotherapy taxane (T RT) maintenance chemotherapy.We retrospectively reviewed 16 CAS treated T RT 12 S RT. None had distant metastasis. Tumour sites included scalp (n = 25) limbs 3). chemotherapy regimens used in were monthly docetaxel 10), biweekly 1), weekly 5) paclitaxel 1)....
Accumulated evidence suggests that glioma stem cells (GSCs) may contribute to therapy resistance in high-grade (HGG). Although recent studies have shown the serine/threonine kinase maternal embryonic leucine-zipper (MELK) is abundantly expressed various cancers, function and mechanism of MELK remain elusive. Here, we demonstrate depletion by shRNA diminishes growth GSC-derived mouse intracranial tumors vivo, induces glial fibrillary acidic protein (+) differentiation GSCs leading decreased...
Refractory ulcerative colitis (UC) that does not respond to medical therapy often requires surgery even during pregnancy. Although surgical cases of UC pregnancy were reported previously, the standard strategy for both and was unclear. Herein, fetal maternal safety as well this unusual procedure in patients with are considered. A 28-year-old woman diagnosed left-sided moderate at 12 weeks pregnancy; toxic megacolon suspected, required. baby's gestational age 23 3 days, a cesarean section...
Prostate-specific membrane antigen (PSMA) is a protein that overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy. Near-infrared photoimmunotherapy (NIR-PIT) highly selective tumor treatment employs antibody-photoabsorber conjugate (APC). Here, we describe the efficacy of NIR-PIT, using fully human IgG1 anti-PSMA monoclonal antibody (mAb), conjugated to photoabsorber, IR700DX, PSMA-expressing PC3 cell line. Anti-PSMA-IR700 showed specific binding...
Enantioselective three-component synthesis of propargylamines from aldehydes, amines, and aliphatic alkynes was catalyzed by a CuI complex 1,3-bis(imidazolin-2-ly)pyridine (pybim). The reaction is applied to wide variety aromatic aldehydes give products with excellent yields (up 93 %) enantiomeric excess 98 % ee) (see scheme; Bz=benzoyl, OTf=trifluoromethanesulfonate). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but...
Abstract Enantioselective Friedel–Crafts alkylations of a variety indoles with ethyl 3,3,3‐trifluoropyruvate catalyzed by novel chiral m ‐phenylenebis(imidazoline)‐copper(II) complexes or the bis(imidazoline)‐achiral acid combination afforded products high enantioselectivity. Both enantiomers indole derivatives can be prepared enantioselectivities tuning N‐substituents imidazoline.
The model dicotyledon Arabidopsis thaliana has a characteristic small sub-family of phytochrome-interacting bHLH (basic Helix-Loop-Helix) factors, which are collectively designated the PIL (or PIF) (PHYTOCHROME INTERACTING FACTOR-LIKE) family proteins. In this study, we identified and characterized set highly homologous members (designated OsPIL11 to OsPIL16) in monocotyledon rice (Oryza sativa). Some them (OsPIL11, OsPIL12, OsPIL13) showed ability interact with putative OsPRR1...
Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes cancer. Anti-CD44 monoclonal antibodies (mAb) are a potential therapy against CD44 expressing OSCC; however, to date therapeutic effects have been disappointing. Here, new cancer treatment described, near-infrared photoimmunotherapy (NIR-PIT), that uses anti-CD44 mAbs conjugated photoabsorber IR700DX. This conjugate injected into mice harboring three syngeneic murine oral (MOC) lines, MOC1...
Aim Triple-negative breast cancer (TNBC) is considered one of the most aggressive subtypes cancer. Near infrared photoimmunotherapy (NIR-PIT) a treatment that employs an antibody-photosensitizer conjugate (APC) followed by exposure NIR light for activating selective cytotoxicity on targeted cells and may have application to TNBC. In order minimize dose APC while maximizing therapeutic effects, dosing need be optimized. this study, we investigate in vitro vivo efficacy cetuximab (cet)-IR700...
Near Infrared-Photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photo-absorber conjugate (APC). Programmed cell death protein-1 ligand (PD-L1) emerging as molecular target. Here, we describe the efficacy of NIR-PIT, using fully human IgG1 anti-PD-L1 monoclonal antibody (mAb), avelumab, conjugated to photo-absorber, IR700DX, in PD-L1 expressing H441 line, papillary adenocarcinoma lung. Avelumab-IR700 showed specific binding and cell-specific killing...
Purpose To identify the body size parameter that exhibits best correlation with aortic and hepatic enhancement at dynamic computed tomography (CT) in a large patient population enrolled multicenter study. Materials Methods This prospective study was approved by ethics committee of each 31 participating institutions where 1342 patients were between April 2012 September 2013. All provided either written or oral informed consent. underwent CT, which included preenhanced, arterial phase (HAP),...
To evaluate the effect of a deep learning-based reconstruction (DLR) method on conspicuity hypovascular hepatic metastases abdominal CT images.This retrospective study with institutional review board approval included 58 patients metastases. A radiologist recorded standard deviation attenuation in paraspinal muscle as image noise and contrast-to-noise ratio (CNR). CNR was calculated region interest ([ROI]L - ROIT)/N, where ROIL is mean liver parenchyma attenuation, ROIT, tumor N, noise. Two...
Glypican-3 (GPC3) represents an attractive target for hepatocellular carcinoma (HCC) therapy because it is highly expressed in HCC but not adult normal tissue. Recently, high affinity anti-GPC3 antibodies have been developed; however, full may penetrate evenly into tumor parenchyma, reducing their effectiveness. In this study, we compared a whole IgG antibody, YP7, with human heavy chain HN3, regard to relative therapeutic effects. Both YP7 and HN3 bound GPC3-positive A431/G1 cells were...
Backgrounds and Aims: Hepatocyte Growth Factor (HGF)-MET signaling is known to promote biological functions such as cell survival, motility, proliferation. However, it unknown if HGF-MET alters the macrophage phenotype. In this study, we aimed study effects of on M1 Methods Materials: Bone marrow-derived macrophages (BMDMs) isolated from mice were either polarized an phenotype by IFN-and LPS treatment or M2 IL-4 treatment. Changes in markers induced evaluated. Mechanisms responsible for...