A5102119505- Particle physics theoretical and experimental studies
- Black Holes and Theoretical Physics
- Cosmology and Gravitation Theories
- Pharmacogenetics and Drug Metabolism
- Quantum Chromodynamics and Particle Interactions
- Ion Transport and Channel Regulation
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Noncommutative and Quantum Gravity Theories
- Neutrino Physics Research
- Ion channel regulation and function
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Hearing, Cochlea, Tinnitus, Genetics
- Drug Transport and Resistance Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Atomic and Subatomic Physics Research
- Inflammatory Bowel Disease
- Dark Matter and Cosmic Phenomena
- Ion Channels and Receptors
- Mass Spectrometry Techniques and Applications
- Connexins and lens biology
- Quantum Mechanics and Applications
Osaka University
2011-2024
Tohoku University
2020-2023
IFOM
2023
Kokushikan University
2023
Niigata University of Pharmacy and Medical and Life Sciences
2015-2023
Osaka University of Pharmaceutical Sciences
2003-2021
Osaka Medical and Pharmaceutical University
2007-2020
Nihon University
2018-2020
The University of Tokyo
2003-2018
Mitsubishi Heavy Industries (Japan)
2018
To assess the genotype pattern of S-mephenytoin 4'-hydroxylation in an extended Japanese population.One hundred eighty-six unrelated, healthy subjects were genotyped for 4'-hydroxylase (CYP2C19) according to a genotyping technique identify wild-type (wt) gene and two mutations, CYP2C19m1 exon 5 CYP2C19m2 4. Fourty-six 186 phenotyped with racemic mephenytoin using conventional 8-hour urine analysis 4'-hydroxymephenytoin.The frequency poor metabolizers by was 18.8% (35 subjects), consisting 12...
UGT2B7 catalyses the glucuronidation of a diverse range drugs, environmental chemicals and endogenous compounds. Hence, coding region polymorphisms are potentially pharmacological, toxicological physiological significance. Two variant cDNAs encoding enzymes with either His or Tyr at residue 268 have been isolated. The variants, referred to as UGT2B7*1 UGT2B7*2, respectively, arise from C T transversion nucleotide 802 region. Analysis genomic DNA 91 unrelated Caucasians 84 Japanese...
Objective To determine whether genetic polymorphism of cytochrome P450 (CYP) 2C9 or 2C19 affects the in vivo metabolism warfarin enantiomers. Methods Eighty-six Japanese patients heart disease who were given participated study. Plasma unbound concentrations enantiomers and urinary (S)-7-hydroxywarfarin measured by means a chiral HPLC ultrafiltration technique to calculate oral clearance (CLpo,u) for formation (CLm) (S)-warfarin 7-hydroxylation. Genotyping CYP2C9 (the wild type [wt], Arg144...
Claudins are cell adhesion molecules working at tight junctions (TJs) that directly involved in compartmentalization multicellular organisms. The cochlea includes a rather peculiar compartment filled with endolymph. This is characterized by high K+ concentration (∼150 mM) and positive endocochlear potential (∼90 mV; EP), both indispensable conditions for cochlear hair cells to transduce acoustic stimuli electrical signals. These thought be generated the stria vascularis, which adjacent...
Double-barreled potassium or chloride ion-selective microelectrodes were constructed using a liquid ion exchanger. Technical details of the fabrication double-barreled microelectrodes, having PD sensor as one barrel and an ionic other, are described. The sensitivity K+ CI- exhibited approximately Nernstian response over temperature range 7 degrees-37 degrees C, electromotive force (EMF) was stable within +/- mV for few hours. rise time less than 1 sec. effect pH on electrode negligible...
The pharmacokinetic profile of omeprazole was examined in 27 healthy Japanese volunteers, and the results were analyzed relation to genotype for two mutations, CYP2C19m1 exon 5 CYP2C19m2 4, associated with poor metabolizer phenotype. Of individuals analyzed, 10 homozygous wild-type (wt) allele both 4 (wt/wt; 37.0%, pattern G1), five heterozygous (wt/m1; 18.5%, G2), (wt/m2; G3), defects (m1/m2; 7.4%, G4), (m1/m1; G5). frequencies m1 m2 mutation 0.31 0.13, respectively. A correlation between...
ABSTRACT An alkaliphilic actinomycete, Nocardiopsis prasina OPC-131, secretes chitinases, ChiA, ChiB, and ChiBΔ, in the presence of chitin. The genes encoding ChiA ChiB were cloned sequenced. open reading frame (ORF) chiA encoded a protein 336 amino acids with calculated molecular mass 35,257 Da. consisted only catalytic domain showed significant homology family 18 chitinases. chiB ORF 296 31,500 is modular enzyme consisting chitin-binding type 3 (ChtBD 3) domain. similarity to Streptomyces...
Despite high sequence identity, UGT1A3 and UGT1A4 differ in terms of substrate selectivity. glucuronidates the planar phenols 1-naphthol (1-NP) 4-methylumbelliferone (4-MU), whereas converts tertiary amines lamotrigine (LTG) trifluoperazine (TFP) to quaternary ammonium glucuronides. Residues 45 154 (which incorporate 21 35 amino acid differences) 535 were exchanged between generate UGT1A3-4<sub>(45–535)</sub>, UGT1A3-4<sub>(45–154)</sub>-3, UGT1A4-3<sub>(45–535)</sub>,...
We explore the possibility to make use of cosmological data look for signatures unknown heavy particles whose masses are on order Hubble parameter during time inflation. To be more specific we take up quasi-single field inflation model, in which isocurvaton $σ$ is supposed particle. study correlation functions involving both scalar ($ζ$) and tensor ($γ$) perturbations search imprints $σ$-particle effects. technique effective theory derive $ζσ$ $γζσ$ couplings. With these couplings compute...
Azathioprine (AZA) is frequently used in patients with inflammatory bowel disease (IBD). However, toxic adverse reactions develop and limit the clinical benefits. Currently, precise mechanisms underlying thiopurine-related toxicity are not well understood. To investigate relationship between extent of thiopurine metabolism Japanese IBD patients, we prospectively observed 48 who received AZA. We analyzed S-methyltransferase (TPMT) inosine triphosphate pyrophosphatase (ITPA) gene mutations...
The effects of various CYP2D6 genotypes on the steady-state plasma concentrations (Css) risperidone and its active metabolite, 9-hydroxyrisperidone, were studied in 85 Japanese schizophrenic patients (27 men 58 women) treated with 6 mg/d for at least 2 weeks. Plasma 9-hydroxyrisperidone measured using liquid chromatography–tandem mass spectrometry. had following genotypes: wild-type (wt) /wt (40 patients), * 10 (* 10)/ wt (28), 5 5)/ (8), 10/ (5), 5/ (3), 4/CYP2D6 14 (1), respectively. Css...
The method of a conformal transformation is applied to general class single field inflation models with non-minimal coupling gravity and non-standard kinetic terms, in order reduce the cosmological perturbative calculation conventional minimal case all orders perturbation theory. Our analysis made simple by fact that variables comoving gauge are conformally invariant orders. structure vacuum, on which correlation functions evaluated, also discussed. We show how quantization Jordan frame for...
The constraint on the $R$-parity violating supersymmetric interactions is discussed in light of current experimental data electric dipole moment neutron, $^{129}$Xe , $^{205}$Tl, and $^{199}$Hg atoms, YbF ThO molecules. To investigate constraints without relying upon assumption dominance a particular combination couplings over all rest, an extensive use made linear programming method scan parameter space. We give maximally possible values for EDMs proton, deuteron, $^3$He nucleus,...
It has been shown that risperidone (+)‐9‐hydroxylation is enantioselectively catalyzed by the polymorphic CYP2D6 in human liver. This study aimed to examine effect of genotype on schizophrenic patients. Subjects were 38 Japanese inpatients receiving 6 mg/day risperidone. Plasma concentrations and (+)‐ (−)‐9‐hydroxyrisperidone at steady state quantified using LC/MS/MS HPLC with α1 acid‐AGP chiral column, respectively. The * 5 (* ) 10 alleles identified polymerase chain reaction (PCR) methods....