A5031524327- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Erythrocyte Function and Pathophysiology
- Fetal and Pediatric Neurological Disorders
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- Mechanical Circulatory Support Devices
- Intestinal Malrotation and Obstruction Disorders
- Congenital Diaphragmatic Hernia Studies
- Estrogen and related hormone effects
- Prenatal Screening and Diagnostics
- Immune Response and Inflammation
- Congenital Heart Disease Studies
- Parvovirus B19 Infection Studies
- Retinopathy of Prematurity Studies
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Adipokines, Inflammation, and Metabolic Diseases
- Vascular anomalies and interventions
- Reconstructive Surgery and Microvascular Techniques
- Pregnancy and Medication Impact
- RNA regulation and disease
- Autoimmune and Inflammatory Disorders Research
University of Tsukuba Hospital
2019-2025
University of Tsukuba
2015-2025
Hitachi General Hospital
2005
Boston Children's Hospital
1999
Ibaraki Children's Hospital
1994-1999
Futaba (Japan)
1994
Abstract Background Neonatal abstinence syndrome (NAS) is characterized by withdrawal symptoms in neonates because of the discontinuation transplacental drug transfer after delivery. Although use neuropsychiatric drugs pregnant women associated with onset NAS (Kanemura, 2020), it remains unclear which types and how many are risk for NAS. Aims & Objectives The aim this study to investigate type number association Method Three hundred sixteen mothers who were receiving (antipsychotics,...
Nucleated red blood cells (NRBCs) are precursors of (RBCs), but also possess variety immunomodulatory effects. However, among the three types NRBCs, immunological effects human CD45− NRBCs remain largely unknown. We have previously shown that cord blood‐derived and adult peripheral monocytes cocultured in a lipopolysaccharide (LPS)‐stimulated indirect coculture system avoided cell‐to‐cell contact, increase IL‐10 decrease TNF‐ α secretion, suggesting an immunosuppressive function via unknown...
Infants born in Japan are reported to have a low incidence of necrotizing enterocolitis (NEC) among countries, and these differences remained significant after adjusting for common clinical factors. To investigate the impact ethnic background, we compared NEC between infants those mothers Japanese ethnicity California. Preterm 2008 2019 at 22–29 weeks gestational age were analyzed retrospectively. Four groups analyzed: (JP), California (JP-J), with but United States or another country...
Therapeutic hypothermia is recommended for moderate and severe neonatal encephalopathy, but being applied to a wider range of neonates than originally envisaged. To examine the clinical use therapeutic hypothermia, data collected during first 3 years (2012-2014) Baby Cooling Registry Japan were analysed. Of 485 cooled neonates, 96.5% ≥36 weeks gestation 99.4% weighed ≥1,800 g. Severe acidosis (pH < 7 or base deficit ≥16 mmol/L) was present in 68.9%, 96.7% required resuscitation >10 min....
Many algorithms to detect copy number variations (CNVs) using exome sequencing (ES) data have been reported and evaluated on their sensitivity specificity, reproducibility, precision. However, operational optimization of such for a better performance has not fully addressed. ES 1199 samples including 763 patients with different disease profiles was performed. were analyzed CNVs by both the eXome Hidden Markov Model (XHMM) modified Nord's method. To efficiently rare CNVs, we aimed decrease...
Adiponectin, one of the adipocytokines, is postulated to play a key role in fetal growth, probably enhancing growth-promoting effect insulin through insulin-sensitizing action.To examine how different intrauterine or postnatal growth patterns relate adiponectin secretion, we measured serum concentrations 30 appropriate-for-gestational-age (AGA) and 19 small-for-gestational-age (SGA) preterm infants on first day life at term-equivalent age.The levels increased significantly all from birth...
Therapeutic hypothermia following neonatal encephalopathy is neuroprotective. However, approximately one in two cooled infants still die or develop permanent neurological impairments. Further understanding of variables associated with the effectiveness cooling important to improve therapeutic regimen. To identify clinical factors short-term outcomes infants, data 509 registered Baby Cooling Registry Japan between 2012 and 2014 were evaluated. Independent death during initial hospitalization...
Importance The risk of premature infants in neonatal incubators exposed to evaporated alcohol from alcohol-based disinfectants (ABDs) is unknown. Objective To assess concentrations the peripheral blood and incubators. Design, Setting, Participants A quality improvement study comparing 2 different populations before after introduction ABD practice (ABD-PRAC) was conducted a intensive care unit single tertiary hospital Japan. included who were born 34 weeks gestational age received medical...
Abstract Neonatal immune regulation transitions from fetal immunity and varies with maturation status, but its role in neonatal cow's milk protein allergy (CMPA) remains unknown. We studied the association between status at birth CMPA. Clinical laboratory data of neonates presenting CMPA symptoms were retrospectively collected two tertiary hospitals. Patients assessed according to gestational age birth: preterm, late‐preterm, full‐term. Fifty‐five infants (26 females, 14 15 26 full‐term)...
To assess the role of prostaglandin E
To investigate the features of erythrocyte metabolism in extremely immature infants, we assayed 21 enzyme activities and glutathione level cord erythrocytes from 28 low-birth-weight infants (ELBWI; defined as birth weight <1,000 g). The results were compared with those normal adults non-neonatal reticulocyte-rich controls. Statistical analysis revealed that six enzymes (glucosephosphate isomerase, phosphoglycerate kinase, monophosphoglycerate mutase, enolase, glucose-6-phosphate...
Objective To examine the mortality and morbidities of very low birthweight (VLBW, <1500 g) infants mothers with hyperglycaemia in pregnancy. Design setting We conducted a retrospective cohort study using data from Neonatal Research Network Japan, nationwide registry VLBW (2003–2012). Patients studied 29 626 born at 23 to 32 weeks without major congenital anomalies, which 682 (2.3%) were pregnancies affected by maternal hyperglycaemia. Main outcome measures The primary was hospital...
Few studies have investigated the hospital-based care utilization of children with medical complexity (CMC) in Japan. This study examined frequency and differences for CMC according to level (moderate severe).Medical records three pediatric tertiary hospitals one prefecture were 2014. We number outpatient visits admissions hospital 5 years after introduction home care.Of 92 CMC, 55 had that was moderate (CMC-moderate) 37 severe (CMC-severe). The who introduced at increased year by year,...
Abstract We here report the first case of discordant Pena–Shokeir phenotype observed in monoamniotic twins. A 34‐year‐old woman, pregnant with twins, was referred at 10 weeks' gestation because one twins had increased nuchal translucency. Serial ultrasonographic examinations suggested that twin may have several other abnormalities, including pleural effusion 21 gestation, decreased movement and contracted limbs 24 weeks, fetal growth restriction 26 weeks. No abnormalities were B. At 34 weeks...
Abstract We report a case of alveolar capillary dysplasia, wherein duodenal atresia was diagnosed during the third trimester. A 36‐year‐old mother referred to our hospital for polyhydramnios at 31 weeks' gestation. Duodenal suspected from ultrasonographic findings, which showed gastric dilation. Other findings noted were enlarged, highly echogenic lungs, spherical heart and an increased lung–thorax transverse area ratio. male infant born 37 The serial radiography infant's upper...
Abstract We describe a female neonate with large flaccid pustules on her trunk and extremities. Cultures were negative, Wright‐stained smear of pustule contents showed numerous eosinophils (>90%). The resolved without leaving pigmentation after 2 weeks. diagnosed this case as sterile transient neonatal pustulosis.
We herein report a neonate who presented with non-bilious vomiting at one day of age caused by prepyloric ectopic pancreas. Ultrasonography clearly detected the presence submucosal mass preoperatively, which was treated local gastric resection. Only 9 neonates symptomatic pyloric or pancreas have been previously reported in literature. Therefore, we reviewed and discussed clinical features this type
BACKGROUND:The interference of biotin administration with thyroid function tests has been reported; however, it remains unclear in clinical practice. In this report, we present the case a neonate diagnosis pontocerebellar hypoplasia type 6 (PCH6) treated who developed laboratory tests. CASE REPORT:A 1-day-old male infant hypothermia, tachypnea, and lactic acidosis had suspected mitochondrial disease. Biotin several vitamins were administered to improve his condition. On day 14, revealed free...