A5021777083- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Adipose Tissue and Metabolism
- Antimicrobial Resistance in Staphylococcus
- Neutropenia and Cancer Infections
- Mycobacterium research and diagnosis
- Hormonal Regulation and Hypertension
- Muscle metabolism and nutrition
- COVID-19 and healthcare impacts
- Renin-Angiotensin System Studies
- Infectious Diseases and Tuberculosis
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular and exercise physiology
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Apelin-related biomedical research
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Heart Rate Variability and Autonomic Control
- Hematological disorders and diagnostics
- Bacterial Infections and Vaccines
- Herpesvirus Infections and Treatments
- Antibiotic Use and Resistance
- Liver Disease Diagnosis and Treatment
St. Luke's International Hospital
2016-2025
St. Luke's International University
2021-2024
Nerima General Hospital
2024
Tohoku University
2009-2023
The University of Texas MD Anderson Cancer Center
2014-2021
Tokyo Medical Center
2021
National Hospital Organization
2021
Wakayama University
2020
Kokusai Junior College
2020
Pain and Rehabilitation Medicine
2010-2015
The coronavirus disease 2019 (COVID-19) pandemic has placed considerable psychological strain on frontline health care workers (HCWs).1 Although the problem of burnout, which overlaps with symptoms depression,2 remains urgent, few studies have addressed it comprehensively. objective this study was to evaluate prevalence burnout among HCWs during COVID-19 in Japan based job categories and other factors.
The non-structural X protein, HBx, of hepatitis B virus (HBV) is assumed to play an important role in HBV replication. Woodchuck protein indispensable for replication, but the duck not. In this study, we investigated whether HBx replication vivo using human hepatocyte chimeric mice. HBx-deficient (HBx-def) was generated HepG2 cells by transfection with overlength genome. Human mice were infected HBx-def or without hepatic expression hydrodynamic injection plasmids. Serum levels and sequences...
Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology a variety renal diseases, such as CKD, AKI, steroid–resistant nephrotic syndrome. Antioxidant therapies being investigated, but clinical outcomes have yet to be determined. Recently, we reported that newly synthesized indole derivative, mitochonic acid 5 (MA-5), increases cellular ATP level survival fibroblasts from patients with mitochondrial disease. MA-5 modulates synthesis...
Background: In this international multicenter study, we aimed to determine the independent risk factors associated with increased 30 day mortality and impact of cancer novel treatment modalities in a large group patients without COVID-19 from multiple countries. Methods: We retrospectively collected de-identified data on cohort diagnosed between January November 2020 16 centers. Results: analyzed 3966 confirmed patients, 1115 2851 patients. Patients were more likely be pancytopenic have...
Mitochondria are key organelles implicated in a variety of processes related to energy and free radical generation, the regulation apoptosis, various signaling pathways. Mitochondrial dysfunction increases cellular oxidative stress depletes ATP inherited mitochondrial diseases also many other metabolic neurodegenerative diseases. characterized by respiratory chain, caused mutations genes encoded either nuclear DNA or DNA. We have hypothesized that chemicals increase levels may ameliorate...
To determine the prevalence of burnout according to job category after first wave COVID-19 in Japan and explore its association with certain factors.An online cross-sectional survey health care workers (HCWs) from June 15 July 6, 2020, was conducted at a tertiary hospital Tokyo, Japan. Demographic characteristics, results Japanese version Maslach Burnout Inventory-General Survey, types anxiety stress, changes life work peak pandemic, support aimed reducing physical or mental burden, were...
Abstract Background While numerous studies have investigated the correlations among time to positivity (TTP) in blood cultures, number of positive bottles, and mortality rates, association with metastatic lesion formation Staphylococcus aureus (S. aureus) bacteremia remains poorly understood. This investigation aims assess impact on severity the, mortality, frequency lesions. Study Population Flowchart illustrating categorization S. aureus-positive culture cases for assessing TTP, bottle...
ABSTRACT Invasive aspergillosis is considered to occur in patients with neutropenia and cellular immunodeficiency, but co‐infection bacterial infections due odontogenic rare possible. Diagnosis relies on culture tissue examination as sensitivity serum galactomannan antigen low immunocompetence.
Abstract A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab bendamustine had finished 6.5 years ago. Discontinuing palbociclib using mirtazapine, she is alive year after diagnosis PML. It rare for to be diagnosed long the last dose rituximab bendamustine. We will discuss possible involvement in course
Objectives Patients with chronic renal failure are restricted to mild physical activity and tend a lack of exercise. However, there have been few reports regarding the influence exercise on progression disease. Similarly, animal models concerned effect training improving function. Therefore, we assessed effects moderate treadmill in remnant kidney model spontaneously hypertensive rats (SHR) failure. We also antihypertensive therapy Design methods Eight-week-old SHR were subjected 5/6...
Exercise training is known to have antihypertensive effects in humans and animals with hypertension, as well exhibit renal protective animal models of hypertension chronic failure. However, the mechanisms regulating these exercise remain unclear. The present study examined on nitric oxide synthase (NOS) kidneys spontaneously hypertensive rats (SHR) normotensive Wistar-Kyoto (WKY) rats. Male SHR WKY were randomly divided into a sedentary group treadmill for 8 weeks. Systolic blood pressure...
Objective: To clarify the mechanisms of renal protective effects exercise training, we examined training on interstitial fibrosis and renin–angiotensin system (RAS) in rats with chronic failure. Methods: Six-week-old male Sprague-Dawley were divided into three groups: sham operation; 5/6 nephrectomy + sedentary; training. The group underwent treadmill running (20 m/min, 60 min/day, 5 days/week). After 12 weeks, function, histology protein expression collagen type I, transforming growth...
Abstract Background Empyema necessitans (EN) is a rare condition characterized by pleural infection with pus spreading into adjacent soft tissues. Although Mycobacterium tuberculosis and Actinomyces israelii are common causative agents, methicillin-resistant Staphylococcus aureus (MRSA) relatively rare, but it associated high mortality in empyema cases. We aimed to report unique case of EN caused MRSA present literature review better understand this condition. Case presentation A 69-year-old...
Abstract Background Resistant bacterial infections, particularly those caused by gram-negative pathogens, are associated with high mortality and economic burdens. Ceftolozane/tazobactam demonstrated efficacy comparable to meropenem in patients ventilated hospital-acquired pneumonia the ASPECT-NP study. One cost-effectiveness analysis United States revealed that ceftolozane/tazobactam was cost effective, but no Japanese studies have been conducted. Therefore, objective of this study assess...
Objective 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, statins reduce blood pressure and have beneficial effects in cardiovascular kidney diseases. The present study examined the effect of chronic treatment with atorvastatin (ATV) on expression nitric oxide synthase (NOS) activity Rho-kinase Akt spontaneously hypertensive rats (SHRs). Methods SHRs were treated ATV for 8 weeks SBP was measured. expressions endothelial, neuronal inducible NOS (eNOS, nNOS iNOS, respectively)...