A5070302469- Animal Nutrition and Physiology
- Adipose Tissue and Metabolism
- Meat and Animal Product Quality
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Effects of Environmental Stressors on Livestock
- Exercise and Physiological Responses
- Animal Behavior and Welfare Studies
- Physiological and biochemical adaptations
- Moringa oleifera research and applications
- ATP Synthase and ATPases Research
- Rabbits: Nutrition, Reproduction, Health
- Livestock and Poultry Management
- Muscle metabolism and nutrition
- GABA and Rice Research
- Aquaculture Nutrition and Growth
- Antioxidant Activity and Oxidative Stress
- Sirtuins and Resveratrol in Medicine
- High Altitude and Hypoxia
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Coenzyme Q10 studies and effects
- Pharmacological Effects and Assays
- GDF15 and Related Biomarkers
- Calpain Protease Function and Regulation
Tohoku University
2015-2024
Nutrition Sciences (Belgium)
2020
Polish Academy of Sciences
2019
Research Institute Hospital 12 de Octubre
2013
Broiler chickens are highly sensitive to high ambient temperatures due their feathers, lack of skin sweat glands, and productivity. Heat stress (HS) is a major concern for the poultry industry because it negatively affects growth as well immune functions, which increase potential risk infectious disease outbreaks. Therefore, vital elucidate HS's effect on avian system, especially considering global rise in average surface temperature. Our study identified series immunological disorders...
Phytobiotics, also known as phytochemicals or phytogenics, have a wide variety of biological activities and recently emerged alternatives to synthetic antibiotic growth promoters. Numerous studies reported the growth-promoting effects phytobiotics in chickens, but their precise mechanism action is yet be elucidated. Phytobiotics are traditionally for antioxidant activity. However, extensive investigations shown that these compounds anti-inflammatory, antimicrobial, transcription-modulating...
Heat stress is an environmental factor that causes oxidative stress. We found previously acute heat stimulates the production of reactive oxygen species (ROS) in skeletal muscle mitochondria birds, and this was accompanied by increase mitochondrial membrane potential (ΔΨ) due to increased substrate oxidation electron transport chain. also showed avian uncoupling protein (avUCP) expression decreased exposure. The present study clarifies whether ΔΨ a major determinant overproduction ROS...
Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology a variety renal diseases, such as CKD, AKI, steroid–resistant nephrotic syndrome. Antioxidant therapies being investigated, but clinical outcomes have yet to be determined. Recently, we reported that newly synthesized indole derivative, mitochonic acid 5 (MA-5), increases cellular ATP level survival fibroblasts from patients with mitochondrial disease. MA-5 modulates synthesis...
Broiler chickens reared under heat stress (HS) conditions have decreased growth performance and show metabolic immunologic alterations. This study aimed to evaluate the effect of supplementation with a standardized blend plant-derived isoquinoline alkaloids (IQ) on performance, protein catabolism, intestinal barrier function, inflammatory status HS-treated chickens. Three hundred sixty 0-day-old Ross 308 male broiler were randomly distributed into 2 treatment groups: control diet (no...
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies drugs affecting mitochondrial biogenesis are undergoing investigation, although not all them have demonstrated favorable effects the clinic. We recently reported therapeutic drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). increased ATP, rescued disease fibroblasts prolonged life span model "Mitomouse" (JASN, 2016). To investigate potential on various diseases,...
A study using pair-feeding technique was conducted to determine whether heat exposure directly or indirectly (via reduced feed intake) increases intestinal mucosal damage and permeability endotoxin in broiler chickens. Male chickens (Ross 308), 27-d-old, were subjected one of the three treatments (n=8): 1) thermo-neutral conditions (24°C) with ad libitum intake, 2) stress (33°C) 3) under conditions, intake identical that heat-stressed Using these groups, two experiments performed evaluate...
Mitochondria are key organelles implicated in a variety of processes related to energy and free radical generation, the regulation apoptosis, various signaling pathways. Mitochondrial dysfunction increases cellular oxidative stress depletes ATP inherited mitochondrial diseases also many other metabolic neurodegenerative diseases. characterized by respiratory chain, caused mutations genes encoded either nuclear DNA or DNA. We have hypothesized that chemicals increase levels may ameliorate...
Heat stress (HS) causes poor growth, immunosupression and high mortality, through physiological dysfunction. We have reported that 'acute' HS increases mitochondrial reactive oxygen species (ROS) oxidative damage in the skeletal muscle of broiler chickens (Cobb), but this is not for case males laying-type white leghorn (WLH) strain (Mujahid et al., 2005b). now studied effects 'chronic' on performance to different strains chickens. Meat-type male (Ross Cobb) 14d age were arranged according a...
1. The present study was designed to achieve a reduction of reactive oxygen species (ROS)-induced oxidative damage skeletal muscle and improve the performance broiler chickens exposed chronic heat stress. 2. Chickens were given control diet with normal drinking water, or diets supplemented cashew nut shell liquid (CNSL) grape seed extract (GSE), electrolysed reduced water (ERW) for 19 d after hatch. Thereafter, temperature either 34°C continuously period 5 d, maintained at 24°C, on same...
Abstract It has been shown that oleuropein, a phenolic compound in the fruit and leaves of olive tree ( Olea europaea ) induces mammalian uncoupling protein 1 (UCP1) expression via an increased secretion noradrenaline adrenaline. This study investigated effects oleuropein on avian UCP (avUCP) as well genes related to mitochondrial oxidative phosphorylation biogenesis cultured muscle cells, together with reactive oxygen species generation. Oleuropein induced avUCP peroxisome...
Trehalose is composed of two molecules D-glucose joined by an α,α-1,1 glucosidic linkage and has antioxidative anti-inflammatory effects. The present study investigated the effect feeding a trehalose-supplemented diet on growth performance, as well oxidative status intestinal innate immunity juvenile chicks. A total 16 d-old male broiler chicks were used in this study: groups 8 birds fed 0% (control) or 0.5% for 18 d. mean body weight trehalose group was significantly greater than that...
We previously showed that heat stress stimulates reactive oxygen species (ROS) production in skeletal muscle mitochondria of birds, probably via an elevation mitochondrial membrane potential (ΔΨ). To clarify the mechanism underlying ΔΨ, modular kinetic analysis was applied to oxidative phosphorylation heat‐stressed birds (34 °C for 12 h). In exposed stress, ‘substrate oxidation’ (a ΔΨ‐producer) increased compared control (24 °C) although there little difference ‘proton leak’ ΔΨ‐consumer),...
Experiments were conducted to determine the effects of different types paddy rice (dehulled, crushed and untreated whole-grain forms) on growth performance in broiler chickens. In Experiment 1, a control diet containing 41.6% corn (control), three experimental diets 40.7% dehulled, 43% or rice, formulated be iso-caloric (3,100 kcal/kg ME) iso-nitrogenous (20% crude protein), but contain levels fat (6%, 5.6%, 10.7%, respectively). Groups 0-day-old chickens fed ad libitum for 28 d. The average...
1. To clarify the underlying mechanism of hepatic fat accretion due to methionine (Met) deficiency in broiler chickens, present study investigated effect Met on carnitine palmitoyltransferase (CPT) system, which imports fatty acids into mitochondria. 2. Fifteen-d-old male meat-type chickens were fed either a control diet (containing 0.52 g/100 g Met) or Met-deficient 0.27 Met/100 g). After 10-d feeding period, birds killed by decapitation and their livers excised determine CPT1 CPT2 mRNA...
Heat stress is an environmental factor that causes oxidative stress.We found previously acute heat stimulates the production of reactive oxygen species (ROS) in skeletal muscle mitochondria birds, and this was accompanied by increase mitochondrial membrane potential (DY) due to increased substrate oxidation electron transport chain.We also showed avian uncoupling protein (avUCP) expression decreased exposure.The present study clarifies whether DY a major determinant overproduction ROS...
1. Oleuropein (Ole) is a major phenolic compound in Olea europaea, with anti-oxidative, anti-obesity, and anti-inflammatory properties. To explore the effect of Ole on physiology metabolism poultry, this study, evaluated effects feeding low-dose growth performance, metabolic hormonal status, muscle oxidative status growing broiler chickens.2. Thirty-two 8-day-old chickens were assigned to four different treatments, fed either 0 (control), 0.1, 0.5, or 2.5 ppm Ole-supplemented diets for 2...
This study was conducted to determine if dietary supplementation with coenzyme Q10 (CoQ10 ), which can act as a potent antioxidant and is an obligatory cofactor of mitochondrial uncoupling protein, suppresses the heat stress (HS)-induced overproduction reactive oxygen species (ROS) oxidative damage in skeletal muscle birds. The carbonyl protein content significantly higher birds exposed HS treatment (34°C, 12 h) than thermoneutral (25°C). increase suppressed by CoQ10 (40 mg/kg diet)....
This study investigated the intracellular mechanism governing effects of oleuropein (OLE), a phenolic compound Olea europaea, on mRNA expression avian uncoupling protein (avUCP) and mitochondrial biogenesis-related factors, reactive oxygen species (mitROS) generation in primary cultured chicken muscle cells. The OLE-treated cells exhibited increases Avucp ATP5a1z decrease mitROS (p < 0.05), while was canceled by sirtuin-1 (SIRT1) or transient receptor potential vanilloid 1 (TRPV1)...