A5023604169- Neurobiology of Language and Bilingualism
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Reading and Literacy Development
- Language Development and Disorders
- Microtubule and mitosis dynamics
- Advanced biosensing and bioanalysis techniques
- Microbial Natural Products and Biosynthesis
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Carbohydrate Chemistry and Synthesis
- CRISPR and Genetic Engineering
- Antimicrobial Resistance in Staphylococcus
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- Syntax, Semantics, Linguistic Variation
- Natural Language Processing Techniques
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- RNA Interference and Gene Delivery
- Education and Learning Interventions
- Virus-based gene therapy research
- Obsessive-Compulsive Spectrum Disorders
Boehringer Ingelheim (Australia)
2025
Boehringer Ingelheim (United States)
2022-2024
Hanyang University
2006-2023
SK Group (South Korea)
2023
Broad Institute
2019-2022
Temple University
2012-2022
University of Ulsan
2017-2021
Asan Medical Center
2017-2021
Ulsan College
2017-2021
Harvard University
2019-2020
It is widely recognized that the processor has a key role to play in creating and strengthening mapping between form meaning integral language use. Adopting an emergentist approach heritage acquisition, current study considers extent which operation of can contribute account what acquired, subsequently retained or lost, never acquired first place. These questions are explored from two perspectives. First, morphosyntactic phenomena for there apparently substantial input considered, with focus...
During mitotic entry centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase are physically tethered by a proteinaceous linker composed of C-Nap1 filamentous protein, rootletin. Linker disassembly occurs at onset mitosis process known as disjunction is triggered Nek2-dependent phosphorylation C-Nap1. Yet mechanistic consequences unknown. Here, we demonstrate that Nek2...
Aziridine is the smallest nitrogen‐containing heterocycle. It not only an important synthetic target but also a useful building block for constructing biologically active molecules. Due to unique properties and reactivity of aziridine, interest in its applications organic chemistry pharmaceutical industry has grown rapidly recent years. This review highlights significance aziridines as end products and/or precursors medicinally relevant molecules, scope decades.
The first asymmetric total synthesis of (−)-laurefucin (1), a unique C-15 acetogenin with 2,8-dioxabicyclo[5.2.1]decane skeleton, has been accomplished in nine steps 31% overall yield from known oxocene 10. Highlights the highly stereoselective include novel organoselenium-mediated biomimetic hydroxyetherification.
A scalable synthesis of the SMARCA2 degrading PROTAC 1 was developed. The linker fragment derived from (S)-citronellol by oxidative cleavage and diastereoselective aryl Grignard addition to a N-tert-butanesulfinyl aldimine for generation chiral amine stereocenter one-pot borylation/Suzuki reaction biaryl formation. dipeptide prepared T3P-mediated coupling hydroxyproline benzyl ester N-Boc tert-leucine followed capping with 1-fluorocyclopropancarboxylic acid hydrolysis. Unification binding...
In the presence of interferon, proteasome subunits are replaced by their inducible counterparts to form an immunoproteasome (IP) plays a key role in generation antigenic peptides presented MHC class I molecules, leading elicitation T cell‒mediated immune response. Although roles IP other cancers, and inflammatory diseases have been extensively studied, its significance breast cancer is unclear.We investigated expression LMP7, subunit, relationship with system components two cohorts.In 668...
Advances in treating β cell loss include islet replacement therapies or increasing proliferation rate type 1 and 2 diabetes, respectively. We propose developing multiple proliferation-inducing prodrugs that target high concentration of zinc ions cells. Unfortunately, typical two-dimensional (2D) cultures do not mimic vivo conditions, displaying a markedly lowered content, while 3D culture systems are laborious expensive. Therefore, we developed the Disque Platform (DP)-a high-fidelity system...
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts identify molecules promote β-cell proliferation, protection, imaging. However, lack specificity these jeopardizes their therapeutic potential. A general platform for selective release small-molecule cargoes over other islet cells ex vivo or cell-types an organismal context will be immensely valuable advancing diabetes research development. Here, we leverage unusually...
Background/Aim: Neoadjuvant chemotherapy (NAC) can affect tumors and the tumor microenvironment. As changes in tumor-infiltrating lymphocytes (TILs) after NAC resulting clinical significance have not been clearly defined, we evaluated both triple negative breast cancer (TNBC). Materials Methods: TIL level was histologically analyzed pre-NAC biopsy post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma NAC. Results: Forty-three (41.3%) showed decreases level,...
Novel sources of antibiotics are needed to address the serious threat bacterial resistance. Accordingly, we have launched a structure-based drug design program featuring desmethylation strategy wherein methyl groups been replaced with hydrogens. Herein report total synthesis, molecular modeling, and biological evaluation 4-desmethyl telithromycin (6), novel desmethyl analogue third-generation ketolide antibiotic (2) our final in this series. While (6) was found be equipotent against...
Copper catalyzed regioselective and stereospecific coupling between aziridines in situ generated pyridine Grignard reagents is reported. This method provides β-pyridylethylamines with diverse structures functionalities from iodopyridines. β-Pyridylethylamines are potential scaffolds for the synthesis of biologically active compounds often found pharmaceuticals. The challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed...
Cu/Oxide Hybrid Bonding Interconnect (HBI) technology has been used in the mass production of CMOS Image Sensors and advanced packages for fine pitch heterogeneous interconnection. Furthermore, HBI can be implemented high density products demanding good heat dissipation due to HBI's structure lacking micro bumps polymer underfill. Thus, is widely studied field semiconductor assembly. Recently, we have demonstrated chip-to-wafer (C2W) multi stack High Bandwidth Memory (HBM) real devices...
Tumours with a high mutation burden exhibit considerable neoantigens and tumour-infiltrating lymphocytes. RNA editing by ADAR1 is source of changes in epitope. However, expression cancer cells lymphocyte levels triple-negative breast have not been well evaluated. We immunohistochemically examined 681 patients analysed their clinicopathological characteristics. also basal-like tumours using The Cancer Genome Atlas data. Among the patients, 45.8% demonstrated expression. exhibited levels, CD8...
The copper catalyzed regioselective and stereospecific opening of CF3-aziridines is reported. This method focuses on the synthesis α-CF3-β-arylethylamines, which can be potential key intermediates in synthetic analogues biologically active molecules. Density functional theory calculations reveal nature species role LiClMgX2 (X = Cl or I) as a Lewis acid. Further, computed mechanism accounts for high regioselectivity this transformation.
Novel sources of antibiotics are required to keep pace with the inevitable onset bacterial resistance. Continuing our macrolide desmethylation strategy as a source new antibiotics, we report total synthesis, molecular modeling, and biological evaluation 4,10-didesmethyl telithromycin (4), novel desmethyl analogue third-generation drug (2). Telithromycin is an FDA-approved ketolide antibiotic derived from erythromycin (1). We found (4) be four times more active than previously prepared...
Centrioles are assembled during S phase and segregated into 2 daughter cells at the end of mitosis. The initiation centriole assembly is regulated by polo-like kinase 4 (PLK4), major serine/threonine in centrioles. Despite its importance duplication, only a few substrates have been identified, detailed mechanism PLK4 has not fully elucidated. CP110 coiled-coil protein that plays roles centriolar length control ciliogenesis mammals. Here, we revealed specifically phosphorylates S98 position....
Despite numerous advances in spectroscopic methods through the latter part of 20th century, unequivocal structure determination natural products can remain challenging, and inevitably, incorrect structures appear literature. Computational that allow accurate prediction NMR chemical shifts have emerged as a powerful addition to toolbox available for small organic molecules. Herein, we report small, stereochemically rich product from Laurencia majuscula using combination computational total...