A5034844766- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Glycosylation and Glycoproteins Research
- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Cancer therapeutics and mechanisms
- Biochemical and Molecular Research
- Helicobacter pylori-related gastroenterology studies
- Protein Degradation and Inhibitors
- Toxin Mechanisms and Immunotoxins
- Multiple Myeloma Research and Treatments
- Advanced biosensing and bioanalysis techniques
Broad Institute
2019-2020
Harvard University
2019-2020
Brigham and Women's Hospital
2019-2020
University of Toledo
2014-2020
University Surgical Associates
2020
Tianjin Normal University
2010-2013
Nankai University
2013
Tianjin University
2013
Small molecules have been classically developed to inhibit enzyme activity; however, new classes of small that endow functions enzymes via proximity-mediated effect are emerging. Phosphorylation (native or neo) any given protein-of-interest can alter its structure and function, we hypothesized such modifications be accomplished by bring a kinase in proximity the protein-of-interest. Herein, describe phosphorylation-inducing chimeric (PHICS), which enable two example kinases—AMPK PKC—to...
Sialyl Thomsen-nouveau (STn) is a tumor-associated carbohydrate antigen (TACA) that overexpressed in variety of carcinomas such as breast, ovarian, and colon cancer. In normal tissue, STn not detectable, which critical for opportunities developing cancer immunotherapies. A novel, entirely carbohydrate, semisynthetic STn-polysaccharide (PS) A1 conjugate was prepared evaluated C57BL/6 mice. STn-PS combined with commercially available monophosphoryl lipid A-based adjuvant, after immunization,...
Abstract A new functionalized N‐heterocyclic carbene Pd II complex, [1,1′‐(hexylene‐1,6‐diyl)bis(3‐ n ‐butylbenzimidazol‐2‐ylidene)][PdCl 2 (CH 3 CN)] ( ) has been synthesized by reaction of NHC‐Ag transmetalation reagent with PdCl CN) . The molecular structure adopts an open conformation. Complex was tested as a catalyst for Suzuki–Miyaura couplings aryl halides arylboronic acids in water and air. results these efforts show that is efficient precatalyst such reactions. In addition, good...
The α-aminooxy derivative of the Thomsen–Friedenriech tumor-associated carbohydrate antigen has been synthesized in 11 steps. This nucleophilic sugar was then utilized preparation TF-PS A1 conjugate vaccine candidate through oxime bond formation.
An anticancer, entirely carbohydrate conjugate, Globo H-polysaccharide A1 (Globo H-PS A1), was chemically prepared and immunologically evaluated in C57BL/6 mice.
PS B, a CD<sup>4+</sup>T-cell stimulating zwitterionic polysaccharide from<italic>B. fragilis</italic>, was conjugated with aminooxy TF tumor antigen. Immunization revealed Ab specificity to TF. FACS binding MCF-7 but not HCT-116 cells.
The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to poor immunogenicity TF antigen. To overcome challenge, we adopted bivalent conjugate design which introduced both Thomsen-nouveau (Tn) onto immunologically polysaccharide A1 (PS A1). immunological results in C57BL/6 mice revealed that bivalent, Tn-TF-PS increased immune response towards as compared monovalent TF-PS A1. This phenomenon was first...
The anomeric aminooxy GM3 trisaccharide cancer antigen (Neu5Acα2,3Galβ1,4Glcβ-ONH
Abstract This new functionalized NHC‐catalyst shows efficient catalytic activity in the Suzuki‐Miyaura cross‐coupling reaction under aerobic conditions and water as solvent, can be also used for Heck coupling reactions.