A5005221310- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Advanced Sensor and Energy Harvesting Materials
- Catalytic Cross-Coupling Reactions
- Bone Tissue Engineering Materials
- Organic Chemistry Cycloaddition Reactions
- X-ray Diffraction in Crystallography
- Fuel Cells and Related Materials
- Catalytic C–H Functionalization Methods
- Protein Degradation and Inhibitors
- Carbohydrate Chemistry and Synthesis
- Marine Sponges and Natural Products
- Porphyrin and Phthalocyanine Chemistry
- Osteoarthritis Treatment and Mechanisms
- Conducting polymers and applications
- Cyclopropane Reaction Mechanisms
- Inorganic and Organometallic Chemistry
- Crystallization and Solubility Studies
- Collagen: Extraction and Characterization
- Traditional and Medicinal Uses of Annonaceae
- Asymmetric Synthesis and Catalysis
- Membrane Separation Technologies
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
Boehringer Ingelheim (United States)
2022-2024
Louisiana Tech University
2024
University of Rochester
2016
Alfred University
2014
Rochester Institute of Technology
2010-2013
The convergent total synthesis of the manzamine alkaloid (−)-nakadomarin A (1) is described. retrosynthetic analysis recognized spirocycle 3, assembled via an organocatalyst-promoted Michael addition/cyclization between bicyclic lactam 4 and furan aldehyde 5, both accessible from achiral starting materials on a multigram scale. Lactam through SN2′/reduction/Staudinger/retro-aza-Claisen sequence After spirocyclization, nakadomarin completed in only six steps.
A scalable synthesis of the SMARCA2 degrading PROTAC 1 was developed. The linker fragment derived from (S)-citronellol by oxidative cleavage and diastereoselective aryl Grignard addition to a N-tert-butanesulfinyl aldimine for generation chiral amine stereocenter one-pot borylation/Suzuki reaction biaryl formation. dipeptide prepared T3P-mediated coupling hydroxyproline benzyl ester N-Boc tert-leucine followed capping with 1-fluorocyclopropancarboxylic acid hydrolysis. Unification binding...
Abstract Herein, we report new reactivity of the conducting polymer, poly-(3,4-ethylenedioxy thiophene) (PEDOT), where PEDOT mediates a Ritter reaction between alcohols and acetonitrile. The yields were variable in most cases competitive with results obtained using sulfuric acid. Attempts at stoichiometric benzonitrile diphenylmethanol are also reported herein. Finally, described here preliminary mechanistic studies that suggest is behaving as an alcohol-selective or specific Lewis...
Copper is involved in the biosynthesis of collagen, however soluble copper salts dissipate quickly and nanoparticles are cytotoxic. Here we added a novel copper-containing nanomaterial (CuHARS) to assess human chondrocyte function presence copper. Human dermal fibroblasts (HDFs) were also treated as control. Chondrocyte response CuHARS was assessed by chronic treatment (30 ug/ml) followed digital microscopy image analysis cellular features compared normal chondrocytes. Unexpectedly,...
Abstract The efficient copper‐catalyzed construction of imidazopyridinones is described. Beginning from iodopyridinyl ureas, Ullmann coupling provides in good yield. Manufacturing by this process described on 473 kg scale; the scope and limitations substrates also detailed.