A5011764079- Catalytic Cross-Coupling Reactions
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Inorganic and Organometallic Chemistry
- Catalytic C–H Functionalization Methods
- Chemistry and Chemical Engineering
- Computational Drug Discovery Methods
- Cyclopropane Reaction Mechanisms
Boehringer Ingelheim (United States)
2022-2024
Self-optimizing flow reactors have received significant attention in recent years, with Bayesian optimization (BO) being identified as the most effective method for reaction optimization. However, there are many different approaches using BO algorithms, which is overwhelming experimentalists. Here, pharmaceutically relevant amide coupling reactions, we explore "best practices" three areas, to promote efficient design of sustainable processes: (1) A high extent exploration an algorithm was...
Abstract The efficient copper‐catalyzed construction of imidazopyridinones is described. Beginning from iodopyridinyl ureas, Ullmann coupling provides in good yield. Manufacturing by this process described on 473 kg scale; the scope and limitations substrates also detailed.