A5011976584- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Processes in Materials Science
- Crystallography and molecular interactions
- Mesoporous Materials and Catalysis
- Fluorine in Organic Chemistry
- Carbon dioxide utilization in catalysis
- Industrial Gas Emission Control
- Polyoxometalates: Synthesis and Applications
- Gas Sensing Nanomaterials and Sensors
- Oxidative Organic Chemistry Reactions
- Chemical Thermodynamics and Molecular Structure
- Luminescence and Fluorescent Materials
- Carbon Nanotubes in Composites
- Catalysis and Oxidation Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Advanced Photocatalysis Techniques
- Analytical Chemistry and Chromatography
- Electrochemical sensors and biosensors
- Anodic Oxide Films and Nanostructures
- Catalysts for Methane Reforming
- Layered Double Hydroxides Synthesis and Applications
- Bauxite Residue and Utilization
- Metal-Organic Frameworks: Synthesis and Applications
Boehringer Ingelheim (United States)
2021-2025
Hubei University
2024
Yunnan Agricultural University
2020-2023
Boehringer Ingelheim (India)
2023
Southwest Petroleum University
2023
Sichuan Mianyang 404 Hospital
2023
University of Catania
2023
Harbin Institute of Technology
2011-2022
South China University of Technology
2004-2022
Nanjing University
2004-2019
Photoluminescent ZnO/SBA-15 mesoporous materials are prepared by directly grind zinc nitrate into the as-prepared samples occluded with template, and this solvent-free method not only saves time energy, but also enables a large amount of oxide to be highly dispersed in channels silica. The resulting composites exhibit photoluminescence (PL) properties ZnO quantum confinement, SBA-15 illustrates similar UV emission crystalline nanostructures. Besides, is used try detect nitrosamine content...
To determine the pore structure characteristics of different coal ranks in Panguan syncline, both N2 adsorption–desorption (LP-N2GA) and CO2 adsorption (LP-CO2GA) were carried out with goal revealing differentiation evolution total volume (TPV), specific surface area (SSA), size distribution (PSD), shape 14 samples, influences SSA to capability at sizes (supermicroporous < 2 nm, micropore: 2–10 transition pore: 10–100 nm) further discussed. Density functional theory (DFT) is used for...
The ability of natural peptides and proteins to influence the formation inorganic crystalline materials has prompted design synthetic compounds for regulation crystal growth, including freezing water growth ice crystals. Despite their versatility ease structural modification, peptidomimetic oligomers have not yet been explored extensively as crystallization modulators. This report describes a library N -substituted glycine peptoid that possess “dual-action” antifreeze activity exemplified by...
Crystallization of glycine in the cylindrical nanopores anodic aluminum oxide (AAO) revealed formation metastable β-glycine pores having diameters less than 200 nm. Two-dimensional X-ray microdiffraction indicated that [010] axis embedded nanocrystals coincided with pore direction, identical to behavior observed previously polymer monoliths. Whereas were stable indefinitely ambient air and persisted upon heating, they transformed α polymorph standing at room temperature 90% relative humidity...
We focused on the critical role of crystallization active pharmaceutical ingredients (APIs) in drug development, with particular emphasis stability, solubility, and feasibility formulation manufacturing. explored polymorphism APIs formation multicomponent crystals, including salt cocrystal screening, underscoring significance regulatory intellectual property considerations recognizing salts cocrystals solid forms. Our study led to design seven new crystalline forms imatinib, an oncology API....
Superbasic sites have been generated on the mesoporous silica materials for first time, through a new strategy to prepare MgO-modified SBA-15 in one-pot synthesis and then disperse KNO3, possessing good textural structure of host high basic strength (H-) 27.0. The situ coated Mg species passivated silanol groups surface siliceous so that mesostructure could be reserved after composite was loaded with KNO3 activated at temperature. Existence special protection layer MgO also beneficial...
The metastable β polymorph of glycine exhibits a single-crystal-to-single-crystal transformation (SCSCT) to either the α or γ phase with retention crystal habit parent phase. X-ray diffraction and optical microscopy reveal that 51 single crystals phase, 24 form domain orientation matrix, confirming an SCSCT. remaining 27 transform few domains and/or γ, each arising from nucleation event. In three cases → transformations occurred within same crystal. all cases, regardless number domains,...
Accurate and effective oxaliplatin (OXP) concentration detection is essential for maximizing therapeutic advantages reducing negative effects of this anti-cancer therapy. Using a nanocomposite-based sensor, we present in paper novel method electrochemical OXP detection. It made graphitic carbon nitride (g-C3N4) titanium dioxide (TiO2) nanoparticles embedded on glassy electrode (GCE) using the hydrothermal method. The X-ray diffractometer (XRD), scanning electron microscopy (SEM),...
Three industrial case studies are presented from the pharmaceutical companies Boehringer-Ingelheim and Merck & Co., Inc. (Rahway, NJ) demonstrating how solid-state miscible impurities can coprecipitate during scale-up of crystallizations resulting in significant purity challenges. This second part contribution outlines underlying impurity retention mechanism was identified via Solubility-Limited Impurity Purge (SLIP) test, which allowed project teams to establish appropriate mechanism-based...
A short and scalable process for the facile synthesis of chiral spirocyclic isoxazolone 1 was developed demonstrated on a multiple kilogram scale in four steps from readily available starting material 8. To achieve sustainability efficiency, we implemented highly efficient catalytic asymmetric allylic alkylation telescopic chemical process. More than 160 kg were produced as crystalline solid by simple operation with >99:1 er 38% overall yield. The structure further confirmed single-crystal...
Crystallization is routinely employed in industrial chemical synthesis to remove undesired impurities and obtain the product as a crystalline solid. A common impurity retention mechanism crystallization formation of solid solutions, where partially miscible state with product. If level high enough exceed solid-state miscibility limit or solvus, second solid-solution phase may form. This event often erratic, causing an unexpected rise level, which can then lead significant challenges...
Abstract Two novel porous nitrosamine traps have been synthesized in order to eliminate carcinogens from the environment. A functional mesoporous material, CuO/SBA‐15, has by using an in‐situ coating method, with addition of a guest salt reaction system modify materials before particles SBA‐15 were incubated; synthesis and modification processes performed single step. The resulting composites selectively adsorb N ‐nitrosopyrrolidine (NPYR), typical volatile nitrosamine, are potential...
Copper catalyzed regioselective and stereospecific coupling between aziridines in situ generated pyridine Grignard reagents is reported. This method provides β-pyridylethylamines with diverse structures functionalities from iodopyridines. β-Pyridylethylamines are potential scaffolds for the synthesis of biologically active compounds often found pharmaceuticals. The challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed...
The copper catalyzed regioselective and stereospecific opening of CF3-aziridines is reported. This method focuses on the synthesis α-CF3-β-arylethylamines, which can be potential key intermediates in synthetic analogues biologically active molecules. Density functional theory calculations reveal nature species role LiClMgX2 (X = Cl or I) as a Lewis acid. Further, computed mechanism accounts for high regioselectivity this transformation.
Carbide slag and bentonite were used to prepare adsorbents remove H 2 S. And S was removed in the form of CaS sulfate.
Abstract This paper investigates the effect of fitting fins at corners a square cylinder on aerodynamic characteristics via wind tunnel tests and large eddy simulations (LES). Although it has been recognized that corner have remarkable cylinder, no study carried out to systematically evaluate this reveal underlying mechanism. Three types fin configurations, i.e. fitted only leading corners, trailing both were studied. It was found significantly influence characteristics, such as mean drag...
Abstract The selective oxidation of aromatics to synthesize valued‐added products is great significance for chemical industry. Molecule oxygen as oxidant the priority this process, however, low efficiency was usually obtained. In work, a new strategy using O 2 and Tert‐butyl hydroperoxide (TBHP) dual oxidants without catalyst proposed. Typical radical process observed when Toluene used substrate. As high 47.1 % conversion 87.6 selectivity benzol acid were obtained, while negligible or...