A5080254475- Gastroesophageal reflux and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Cardiac Ischemia and Reperfusion
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Cardiovascular Effects of Exercise
- Aortic Disease and Treatment Approaches
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Diet and metabolism studies
- Microtubule and mitosis dynamics
- Drug Transport and Resistance Mechanisms
- Adenosine and Purinergic Signaling
Imperial College London
2014-2019
University of Leicester
2014
York District Hospital
1985
During mitotic entry centrosomes separate to establish the bipolar spindle. Delays in centrosome separation can perturb chromosome segregation and promote genetic instability. However, interphase are physically tethered by a proteinaceous linker composed of C-Nap1 filamentous protein, rootletin. Linker disassembly occurs at onset mitosis process known as disjunction is triggered Nek2-dependent phosphorylation C-Nap1. Yet mechanistic consequences unknown. Here, we demonstrate that Nek2...
Healthy cardiomyocytes are electrically coupled at the intercalated discs by gap junctions. In infarcted hearts, adverse gap-junctional remodeling occurs in border zone, where chemically and influenced myofibroblasts. The physical movement of these contacts remains unquantified. Using scanning ion conductance microscopy, we show that intercellular between myofibroblasts highly dynamic, mainly owing to edge dynamics (lamellipodia) Decreasing amount functional connexin-43 (Cx43) membrane...
Increased maternal serum bile acid concentrations in intrahepatic cholestasis of pregnancy (ICP) are associated with fetal cardiac arrhythmias. Ursodeoxycholic (UDCA) has been shown to demonstrate anti-arrhythmic properties via preventing ICP-associated conduction slowing and development reentrant arrhythmias, although the cellular mechanism is still being elucidated.High-resolution fluorescent optical mapping electrical activity electrocardiogram measurements were used characterize effects...
Infarct borderzone (BZ) expansion following myocardial infarction is accompanied by ventricular dilatation, remodeling, and heart failure. We showed that myofibroblasts (MFBs), which are present in the BZ, tend to form functional gap junctions with adjacent cardiomyocytes (CMs) in-vitro such heterocellular pairing depolarizes CMs, induces discontinuity conduction, slows impulse propagation. Connexin-43 (C×43) plays an important role establishing electrical coupling, but its involvement...