A5031217311- Crystallography and molecular interactions
- Thyroid Disorders and Treatments
- Photochromic and Fluorescence Chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Pancreatic function and diabetes
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Chemical Reaction Mechanisms
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- Genetics and Neurodevelopmental Disorders
- Biofuel production and bioconversion
- CRISPR and Genetic Engineering
- DNA and Nucleic Acid Chemistry
- Diabetes and associated disorders
- Trace Elements in Health
- Gold and Silver Nanoparticles Synthesis and Applications
- Polydiacetylene-based materials and applications
- Vanadium and Halogenation Chemistry
- Cellular transport and secretion
- Fluorine in Organic Chemistry
- Advanced Materials and Mechanics
Indian Institute of Science Education and Research, Bhopal
2020-2025
Broad Institute
2019-2023
Brigham and Women's Hospital
2019-2023
Harvard University
2019-2021
Indian Institute of Science Bangalore
2010-2020
Weizmann Institute of Science
2015
Kitasato University
2010
Tehran University of Medical Sciences
2006
Southampton General Hospital
2006
University of Southampton
2006
The first examples of stable spirodiazaselenurane and spirodiazatellurane were synthesized by oxidative spirocyclization the corresponding diaryl selenide telluride structurally characterized. X-ray crystal structures suggest that are distorted trigonal bipyramidal (TBP) with electronegative nitrogen atoms occupying apical positions two carbon lone pair Se/Te equatorial positions. Interestingly, underwent spontaneous chiral resolution during crystallization, absolute configurations its...
Thyroid hormones are essential for the development and differentiation of all cells human body. They regulate protein, fat, carbohydrate metabolism. In this Account, we discuss synthesis, structure, mechanism action thyroid their analogues.The prohormone thyroxine (T4) is synthesized on thyroglobulin by peroxidase (TPO), a heme enzyme that uses iodide hydrogen peroxide to perform iodination phenolic coupling reactions. The monodeiodination T4 3,3′,5-triiodothyronine (T3) selenium-containing...
Abstract Precise control of the self‐assembly selected components within complex mixtures is a challenging goal whose realization important for fabricating novel nanomaterials. Herein we show that by decorating surfaces metallic nanoparticles with differently substituted azobenzenes, it possible to modulate wavelength light at which these induced. Exposing mixture two types nanoparticles, each functionalized different azobenzene, UV or blue induces selective only one type nanoparticles....
Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) by outer- inner-ring deiodination pathways, respectively. These enzymes also further T3 rT3 produce a variety di- monoiodo derivatives. In this paper, deiodinase activity series peri-substituted naphthalenes having different amino groups is described. compounds remove iodine selectively from T4 3,3'-diiodothyronine...
Abstract Halogenated nucleosides can be incorporated into the newly synthesized DNA of replicating cells and therefore are commonly used in detection proliferating living tissues. Dehalogenation these modified is one key pathways involved repair mediated by uracil‐DNA glycosylase. Herein, we report first example a selenium‐mediated dehalogenation halogenated nucleosides. We also show that mechanism for debromination remarkably different from deiodination presence ribose or deoxyribose moiety...
Abstract Precise control of the self‐assembly selected components within complex mixtures is a challenging goal whose realization important for fabricating novel nanomaterials. Herein we show that by decorating surfaces metallic nanoparticles with differently substituted azobenzenes, it possible to modulate wavelength light at which these induced. Exposing mixture two types nanoparticles, each functionalized different azobenzene, UV or blue induces selective only one type nanoparticles....
Several genome engineering applications of CRISPR-Cas9, an RNA-guided DNA endonuclease, require precision control Cas9 activity over dosage, timing, and targeted site in organism. While some dose time have been achieved using small molecules, spatial light, no singular system with all the three attributes exists. Furthermore, reported small-molecule systems lack wide dynamic range, background absence controller, are not biologically inert, while optogenetic prolonged exposure to...
The I of the beholder: presented chemical model for inner-ring deiodination thyroxine (T4) and 3,5,3′-triiodothyronine (T3) by iodothyronine deiodinase (see scheme) highlights importance an in-built thiol group in proximity to selenium atom. effective removal iodine case T4 indicates that enol–keto tautomerism is not required deiodination. Detailed facts specialist readers are published as "Supporting Information". Such documents peer-reviewed, but copy-edited or typeset. They made available...
SARS-CoV-2 main protease (Mpro/3CLpro) is a crucial target for therapeutics, which responsible viral polyprotein cleavage and plays vital role in virus replication survival. Recent studies suggest that 2-phenylbenzisoselenazol-3(2H)-one (ebselen) potent covalent inhibitor of Mpro, affects its enzymatic activity Herein, we synthesized various ebselen derivatives to understand the mechanism Mpro inhibition by ebselen. Using derivatives, characterized detailed interaction with Mpro. We...
Organoselenium compounds as functional mimics of iodothyronine deiodinase are described. The naphthyl-based having two selenol groups remarkably efficient in the inner-ring deiodination thyroxine. introduction a basic amino group close proximity to one moieties enhances deiodination. This study suggests that an increase nucleophilic reactivity conserved Cys residue at active site deiodinases is very important for effective
The type 1 iodothyronine deiodinase (1D-1) in liver and kidney converts the L-thyroxine (T4), a prohormone, by outer-ring (5') deiodination to biologically active 3,3',5-triiodothyronine (T3) or inner-ring (5) inactive 3,3',5'-triiodothronine (rT3). Sulfate conjugation is an important step irreversible inactivation of thyroid hormones. While sulfate phenolic hydroxyl group stimulates 5-deiodination T4 T3, it blocks 5'-deiodination T4. We show that thyroxine (T4S) undergoes faster as compared...
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts identify molecules promote β-cell proliferation, protection, imaging. However, lack specificity these jeopardizes their therapeutic potential. A general platform for selective release small-molecule cargoes over other islet cells ex vivo or cell-types an organismal context will be immensely valuable advancing diabetes research development. Here, we leverage unusually...
Injectable hydrogels capable of releasing the desired amount insulin under hyperglycemic conditions will significantly advance smart development. We report glucose-responsive with programmable release properties.
Chemical modifications to Cytosine bases are among the most studied epigenetic markers and their detection in human genome plays a crucial role gaining more insights about gene regulation, prognosis of genetic disorders unraveling inheritance patterns. The methylated at 5
Auf S kommt es an: Das vorgestellte chemische Modell für die Entiodierung des inneren Rings von Thyroxin (T4) und 3,5,3′-Triiodthyronin (T3) durch Iodthyronin-Deiodinase (siehe Schema) unterstreicht Bedeutung einer in Nachbarschaft zum Selenatom eingebauten Thiolgruppe. Die effektive Iodentfernung bei T4 spricht dafür, dass Reaktion keine Enol-Keto-Tautomerie erforderlich ist.