Stimuli-responsive hydrogels (HGs) with a controlled drug release profile are the current challenge for advanced therapeutic applications. Specifically, antidiabetic drug-loaded glucose-responsive HGs being investigated closed-loop insulin delivery in insulin-dependent diabetes patients. In this direction, new design principles must be exploited to create inexpensive, naturally occurring, biocompatible HG materials future. work, we developed chitosan nanoparticle/poly(vinyl alcohol) (PVA)...

Phenylboronic acid (PBA)-containing hydrogels (HGs), capable of glucose-responsive insulin release, have shown promise in diabetes management preclinical studies. However, sustainable material usage and attaining an optimum release profile pose a significant challenge such HG design. Herein, we present the development straightforward fabrication strategy for protein-polymer hybrid HGs (PPHGs). We prepare PPHGs by crosslinking polyvinyl alcohol (PVA) with various nature-abundant proteins, as...

Herb-based extracellular vesicles (EV), inherently replete with bioactive proteins, RNA, lipids, and other medicinal compounds, are noncytotoxic uniquely capable of cellular delivery to meet the ever-stringent challenges ongoing clinical applications. EVs abundant in nature, affordable, scalable, but they also incredibly fragile stuffed many biomolecules. To address low drug binding abilities poor stability EVs, we demonstrated herb-based (isolated from neem, mint, curry leaves) conjugated...

Injectable hydrogels capable of releasing the desired amount insulin under hyperglycemic conditions will significantly advance smart development. We report glucose-responsive with programmable release properties.

Determination of the type sugar present in a beverage is one key parameter assessing their nutritious values. This article presents novel technique hexose identification using hydrogel sensor sample. The uses poly(vinyl alcohol) (PVA) and benzene-1,4-diboronic acid (1,4 BDBA) whose boronate ester bonds break down when they come contact with samples change gel impedance. A tree-construct algorithm proposed to identify type, irrespective its concentration from impedance data at 20 200 kHz....

Aberrantly glycosylated mucin 1 is a critical prognostic biomarker in breast epithelial cancers. Hypoglycosylated coats the surface of cancer cells, where O-glycans are predominantly linked via an N-acetylgalactosamine moiety (GalNAc). Cancer cell-derived extracellular vesicles (EVs) carry biomarkers from parent cells to recipient and, therefore, could potentially be leveraged for diagnostics and noninvasive disease monitoring. We devised label-free approach identifying glycoprotein...

Abstract On‐demand cargo/drug release from hydrogel under physiological conditions is a significant challenge for advanced therapeutics. Specifically, smart hydrogels capable of the glucose‐responsive anti‐diabetic drugs are current research thurst. Despite recent developments, there need more glucose‐sensing that retain properties in wide‐range pH environments. Herein, facile and generalized fabrication strategy multiple stimuli (pH, glucose, hydrogen peroxide)‐responsive reported....

A series of functionalized vinyl cinnamate monomers were synthesized by the reaction hydroxyethylmethacrylate and various substituted cinnamoyl chlorides. Electron donating accepting functional groups such as −OCH3, −Cl −NO2 introduced at para position chloride. Homopolymerization carried out in dimethylformamide using azobisisobutyronitrile a free radical initiator 80°C for 12h. The structures their polymers characterized Fourier transform infrared (FTIR), 1H 13C nuclear magnetic resonance...

Functionalized vinyl cinnamate monomers were synthesized by the reaction between hydroxyethylacrylate (HEA) and substituted cinnamoyl chlorides possessing electron releasing withdrawing functional groups like chloro, methoxy, nitro at para position of aromatic ring. The structures these characterized Fourier transform infrared (FTIR), 1H-, 13C-NMR spectral techniques. homopolymers obtained free radical solution polymerization in dimethylformamide (DMF) 80°C for 12 h using...

Stimuli‐responsive hydrogels (HGs) have shown promise for smart drug delivery applications. Specifically, glucose‐responsive HGs having phenylboronic acid (PBA) functional groups are extensively pursued insulin in hyperglycemia. Current polymeric cumbersome to fabricate and show a limited release profile. Herein, we develop straightforward fabrication of multipolymer (MPHGs) using three‐component situ mixing. Molecular cargo, such as insulin, was loaded during the gelation....

Epigenetic dysregulation including DNA methylation and histone modifications is being increasingly recognized as a promising biomarker for the diagnosis prognosis of cancer. Herein, we devised label-free analytical toolbox comprising IR, UV–vis, CD spectroscopy, cyclic voltammetry, which capable to differentiate significantly hyper-methylated breast cancer chromosomes from normal epithelial counterparts.

Abstract Simultaneous autostep technique, a novel methodology in thermal analysis, was employed for the investigation of multiple stage degradation acrylic polymers thermogravimetric (TG) and differential analysis (DTA) methods. Heating sample controlled automatically with respect to rate mass loss each step addition control heating by given steady rate. Three standard samples (polymethyl acrylate, polymethyl methacrylate, polystyrene) newly synthesized polymer (polycinnamoyloxyethyl...

This paper presents single-model identification algorithm for the classification of sugar sample suitable designing a portable meter in-home application. The is based on impedimetric data typical hydrogel taken over frequency range from 20 Hz to 200 kHz. Principal component analysis (PCA) used reduction and selection dominating principal components. Five impedance features are identified attain maximum accuracy. work identifies quadratic discriminant (QD) as most accurate model among 32...

Abstract Two unsaturated hydrophobic monomers, cinnamoyloxyethyl acrylate (CEA) and methacrylate (CEMA), were synthesized from hydroxyethyl (HEA) (HEMA), respectively, by the esterification reaction with cinnamoyl chloride. FT-IR, 1H- 13C-NMR spectra employed to characterize monomers. These monomers bulk copolymerized HEA HEMA, free-radical polymerization using azobisisobutyronitrile (AIBN). Mechanical properties, thermal behavior, surface morphology of transparent copolymers studied...