A5102776598- Synthesis of β-Lactam Compounds
- Antibiotics Pharmacokinetics and Efficacy
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Antibiotic Resistance in Bacteria
- Asymmetric Synthesis and Catalysis
- NF-κB Signaling Pathways
- Catalytic C–H Functionalization Methods
- Synthesis and Reactions of Organic Compounds
- Synthesis and Catalytic Reactions
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- Chemical synthesis and alkaloids
- Cytokine Signaling Pathways and Interactions
- Cancer therapeutics and mechanisms
- Alzheimer's disease research and treatments
- Synthesis and biological activity
- Carbohydrate Chemistry and Synthesis
- Traditional and Medicinal Uses of Annonaceae
- Natural product bioactivities and synthesis
- Synthesis and Biological Evaluation
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cholinesterase and Neurodegenerative Diseases
- Synthesis of heterocyclic compounds
Catholic University of Korea
2013-2024
Seoul National University
1993-2015
Hanyang University
2015
Sungkyunkwan University
2015
Bucheon St. Mary's Hospital
2014
Soonchunhyang University
2013
Inje University
2013
Korea Institute of Science and Technology
2001-2011
Ibaraki Prefectural University of Health Sciences
2006
Dankook University
2004
The first asymmetric total synthesis of (−)-laurefucin (1), a unique C-15 acetogenin with 2,8-dioxabicyclo[5.2.1]decane skeleton, has been accomplished in nine steps 31% overall yield from known oxocene 10. Highlights the highly stereoselective include novel organoselenium-mediated biomimetic hydroxyetherification.
In control: The first asymmetric total synthesis of (+)-itomanallene A (revised structure) has been accomplished starting from commercially available (S)-glycidol in a substrate-controlled fashion. approach yields α,α′-cis- or α,α′-trans-tetrahydrofuran isomers by intramolecular alkylation with either an amide enolate nitrile anion, respectively. Species the red algal genus Laurencia (Rhodomelaceae, Ceramiales) have prolific source diverse halogenated secondary metabolites.1 Since Kurata et...
The kinetic theory of chemical reactions in dense fluids is extended to calculate the dynamics a reactive pair particles. Given an initial distribution, probability that particles will remain unreacted calculated. Explicit solutions are obtained by taking into account repeated ring events and results shown be generalization Fick’s law calculations for this problem. Other classes dynamical which lead coupling diffusive motion examined more formal way their physical significance discussed....
An intramolecular olefin keto-carbene cycloaddition reaction created the bicyclo[3.1.0]hexane template 10 that was necessary for synthesis of carbocyclic amine 15. This is a direct precursor to family rigid nucleosides are conformationally locked in Southern hemisphere pseudorotational cycle. The adenosine analogue reported herein as an illustrative example methodology. racemic (South)-methanocarba (±)-4 first ribonucleoside version hemisphere.
We describe the design and synthesis of new heterodimeric conjugates, which are comprised a neomycin B (Neo) stem-binding component chloramphenicol (Cam) or linezolid (Lnz) loop-binding component. Some conjugates display enhanced affinities to RNA targets that binding occurs in both stem loop regions RNA. In addition, results foot-printing mutation studies suggest affinity is sequence-specific.
We have developed an efficient three-component tandem reaction for the synthesis of 3-(1,3-diarylallylidene)oxindoles combining three palladium-catalyzed reactions: Sonogashira, Heck, and Suzuki–Miyaura reactions. This method allows a stereoselective approach to each (E)- (Z)-isomer by ligand change controlling temperature.
Liver X receptor (LXR) is a member of the nuclear superfamily, and it regulates various biologic processes, including de novo lipogenesis, cholesterol metabolism, inflammation. Selective inhibition LXR may aid treatment nonalcoholic fatty liver diseases. In present study, we evaluated effects three cinnamamide derivatives on ligand-induced LXR<i>α</i> activation explored whether these could attenuate steatosis in mice. N-(4-trifluoromethylphenyl) 3,4-dimethoxycinnamamide (TFCA) decreased...
A novel one-pot reaction for the synthesis of 3-(diarylmethylene)oxindoles is described. The involves successive combination three palladium-catalyzed reactions (Sonogashira, Heck, and Suzuki–Miyaura reactions). This method enables rapid various from simple propiolamides. addition silver salts dramatically enhanced <i>E</i>/<i>Z</i> stereoselectivity reaction.