In this study, we investigated the synergistic effect of co-administration osimertinib and HAD-B1 using gefitinib-resistant non-small cell lung cancer cells, HCC827-GR. is composed 4 natural drugs, Panax Notoginseng Radix, ginseng C. A. Meyer, Cordyceps militaris, Boswellia carterii Birdwood, has been reported to have therapeutic effects on patients with advanced in several studies. Resistance gefitinib HCC827 cells was acquired through MET activity. Co-treatment reduced viability HCC827-GR...

In the present study, effects of various hederagenin monodesmosides isolated from stem bark Kalopanax pictus NAKAI, such as hederagenin, δ-hederin, kalopanaxsaponin A, I, and sapindoside C, have been evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2) tumor necrosis factor-α (TNF-α) release by macrophage cell line RAW 264.7. Among tested monodesmosides, kalopanxsaponin A was most potent inhibitor NO production, it also significantly decreased PGE2 TNF-α...

Objective: The purpose of this study is both to estimate the efficacy and safety Yukgunja-tang (YGJT) establish evidence for use herbal medicines in management patients with cancer-related anorexia. Methods: We enrolled 40 participants were randomly allocated 2 groups: control group (n = 20), which received nutrition counseling, treatment counseling was administered YGJT at twice a day 4 weeks (a total 56 times @ 3.0 g each time). primary outcome score on anorexia/cachexia subscale (ACS)...

Flavanones in Citrus unshiu peel (CUP) have been used as therapeutic agents to reduce intestinal inflammation; however, the anti-inflammatory effects of their biometabolites remain ambiguous. Here, we identified aglycone-type flavanones, such hesperetin and naringenin, which were more abundant bioconversion CUP than ethanol extracts CUP. We found that induced canonical nuclear factor-κB pathway via degradation IκB Caco-2 cells. To check immune suppressive capacity aglycones vivo, orally...

Background: There were contradictory reports about the relationship between neck circumference (NC) and thyroid status. This study aimed to compare NCs of Korean adults with or without disease. Methods: The data 8,198 subjects (aged 40–80 yr) that participated in 2019-2020 National Health Nutrition Examination Survey subjected analysis. measured by trained staff an accuracy ±0.1 cm a tape measure. Multiple logistic models used assess prevalence disease NC level among men pre- postmenopausal...

The aim of this study was to determine the feasibility, acceptability, and safety using moxibustion for treating anorexia improving quality life in patients with metastatic cancer.We conducted a randomized sham-controlled trial moxibustion. Sixteen cancer were recruited from Daejeon, South Korea. randomly placed into true or sham group received 10 treatments administered abdomen (CV12, CV8, CV4) legs (ST36) over 2-week period. Outcome measures included interest participating trial,...

Liver X receptor (LXR) is a member of the nuclear superfamily, and it regulates various biologic processes, including de novo lipogenesis, cholesterol metabolism, inflammation. Selective inhibition LXR may aid treatment nonalcoholic fatty liver diseases. In present study, we evaluated effects three cinnamamide derivatives on ligand-induced LXR<i>α</i> activation explored whether these could attenuate steatosis in mice. N-(4-trifluoromethylphenyl) 3,4-dimethoxycinnamamide (TFCA) decreased...

In epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC), acquired resistance to EGFR tyrosine kinase inhibitors (TKI) leads disease progression. Strategies overcome the are required in treatment for advanced cancer. this study, we investigated therapeutic effect of afatinib and HangAmDan-B1 (HAD-B1) co-administration gefitinib-resistant NSCLC using HCC827-GR, line with gefitinib resistance, HCC827-GR implanted mouse model. HAD-B1 consists 4 herbs, Panax...

Objectives: The objective of this study was to explore the integration Traditional Korean Medicine (TKM) into existing clinical pathways for treatment gastric cancer. focusing on enhancing outcomes and improving patient quality life.Methods: Employing a prospective observational design, targeted adults aged 20-75 diagnosed with It assessed TKM pathway's impact life, tumor markers, complete blood count test values, satisfaction, monitored adverse reactions evaluate effectiveness...

Abstract Background: Anorexia is a common cause of malnutrition and associated with negative effects on the quality life (QOL) for patients cancer. Management appetite key to improving both QOL prognosis such patients. Yukgunja-tang (YGJT) traditional herbal medicine extensively prescribed in Korea as remedy various gastrointestinal syndromes. Currently, no standardized treatment exists cancer who are suffering from anorexia after surgery, chemotherapy, and/or radiotherapy. For that reason,...

Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic mineral components. This paper aims to identify analyse the proteins in common venomous snakes, Gloydius blomhoffii (G. blomhoffii) Agkistrodon acutus (A. acutus), Korea.We used mass spectrometry, electrophoresis, N-terminal sequencing in-gel digestion these two snake venoms.We identified eight G. four A. venom. The detected venoms were phospholipase A2,...

Abstract Integrative oncology is being increasingly adopted in mainstream cancer care to strengthen anticancer effects and control cancer-related symptoms. The objective of this study identify the characteristics patients with lung treated at an integrative center Korea determine treatment (ICT) on survival outcome traditional Korean medicine (TKM). We reviewed medical records for who visited a single clinical setting, East-West Cancer Center, between January 2014 December 2015. classified...

This study evaluates acute and subchronic toxicity of a Korean herbal formula HAD-B1 in rat to investigate whether has potential humans. First, the assess oral at dose levels 0, 500, 1000, 2000 mg/kg body weight (BW) was performed male female SD rats (Crl: CD, specific pathogen-free) (n = 5/group). Based on result study, 4 weeks’ range finding 13 were (dose DRF; n 5/group) weeks (subchronic study; 10/group) rats. The control group administered with distilled water (DW). Clinical signs,...

Epidermal growth factor receptor mutation-positive non–small cell lung cancer is cared for mainly by target therapeutics in the clinical treatment at present. We investigated antitumor effect of HangAmDan-B1 (HAD-B1) combined with afatinib on H1975 (L858R/T790M double mutation) cells. The HAD-B1 inhibited proliferation cells a dose-dependent manner compared or alone. group significantly induced early apoptosis and cycle arrest afatinib- HAD-B1-treated control group. Profile analysis proteins...

Viscum album var. coloratum (Kom.) Ohwi is a traditional herbal medicine used in East Asia to treat hypertension, skeletal muscle disorders, and cancer. The inhibitory effects of (VA) extract on chemokines its therapeutic potential erlotinib-induced skin rash were investigated this study. ELISA was measure the levels chemokines, MCP-1 RANTES, which are thought be mediators RAW264.7 cells. Western blot analysis look into activation signaling pathways like AKT, MAPK, EGF. In order investigate...

Background: The combination of herbal medicine with conventional treatment increases the survival rate cancer patients, but effect is not great. Hyperthermia may have a synergistic alongside medicine. Objective: To monitor efficacy hyperthermia together Gun-Chil-Jung (GCJ) capsule for event-free (EFS) and overall (OS) various cancers. Methods: We collected data retrospectively on 54 patients all stages. They were divided into 4 groups according to each or GCJ period. 0.46 MHz radiofrequency...

Objectives This pilot study aimed to evaluate the agreement between traditional face-to-face Korean medicine (KM) pattern identification and non-face-to-face KM using data from related questionnaires, tongue image, pulse features in patients with cancer. Methods From January June 2020, 16 participants a cancer diagnosis were recruited at one hospital. Three experienced doctors independently diagnosed whether they belong cold or not, heat deficiency excess not. Another researcher collected...

Objective The purpose of this study is to report the case a patient with recurring non-small cell lung carcinoma (NSCLC) taking Samchilchoongcho-Jung Afatinib. Methods An NSCLC diagnosed multiple bone and pulmonary metastasis was Afatinib (20 mg/day) suffering from stomatitis caused by treated (1,500 for 3 months. tumor size measured computed tomography, laboratory findings, including markers (CEA, Cyfra 21-1), were also followed up. Stomatitis numeric rating scale, adverse events evaluated...

Cancer is one of the leading causes death worldwide, and Korea no exception. Humanity has been fighting cancer for many years, as a result, we now have effective treatments such chemotherapy, radiation, surgery. However, there are other issues that only beginning to address, patients’ quality life. Moreover, numerous studies show addressing these holistically critical overall treatment survival rates. This paper describes how attempting reduce incidence recurrence rates while also managing...