Anne Øvrehus
A5047831950- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV, Drug Use, Sexual Risk
- Liver Disease and Transplantation
- HIV/AIDS drug development and treatment
- SARS-CoV-2 detection and testing
- Innovations in Medical Education
- Systemic Lupus Erythematosus Research
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- COVID-19 Impact on Reproduction
- Autoimmune and Inflammatory Disorders
- Alcohol Consumption and Health Effects
- Radiology practices and education
- Parasitic infections in humans and animals
- Medical Education and Admissions
- COVID-19 and healthcare impacts
- Clinical Reasoning and Diagnostic Skills
- Education, Healthcare and Sociology Research
- Chronic Lymphocytic Leukemia Research
- Student Assessment and Feedback
University of Southern Denmark
2013-2025
Odense University Hospital
2015-2025
Copenhagen University Hospital
2020
Rigshospitalet
2020
Office of Infectious Diseases
2019
Summary The disease burden of hepatitis C virus ( HCV ) is expected to increase as the infected population ages. A modelling approach was used estimate total number viremic infections, diagnosed, treated and new infections in 2013. In addition, model change progression mortality 2013–2030. Finally, expert panel consensus capture current treatment practices each country. Using today's paradigm, projected decline or remain flat all countries studied. However, same time period, individuals with...
SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk breakthrough infection in a fully vaccinated cohort. anti-spike IgG levels were measured before first vaccination at day 21-28, 90 180, as well after booster vaccination. Breakthrough infections captured through Danish National Microbiology database. incidence rate ratio (IRR) for time-updated was determined using Poisson regression. Among...
Summary The number of hepatitis C virus ( HCV ) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used forecast two treatment scenarios: (i) the impact increased efficacy keeping treated patients constant and (ii) increasing rate. This analysis suggests that successful diagnosis a small proportion can contribute significantly reduction burden in countries studied. largest ‐related morbidity mortality occurs when combined higher...
Highlights•Chronic HCV prevalence and treatment rates among PWID vary widely across Europe.•HCV scale-up is required in most sites to reduce transmission.•Increasing OST/NSP coverage enhances prevention benefit.Graphical abstractAbstractBackground & AimsPrevention of hepatitis C virus (HCV) transmission people who inject drugs (PWID) critical for eliminating Europe. We estimated the impact current scaled-up with without scaling up opioid substitution therapy (OST) needle syringe programmes...
To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and the durability of vaccine-induced antibodies.Adults without history SARS-CoV-2 infection from Danish population scheduled for vaccination were enrolled in this parallel group, phase 4 study. Spike IgG Spike-ACE2-receptor-blocking antibodies measured at days 0, 21, 90, 180. Vaccine was categorized according to levels day 90 after first vaccination. Nondurable response defined as day-90...
Older age and chronic disease are important risk factors for developing severe COVID-19. At population level, vaccine-induced immunity substantially reduces the of COVID-19 hospitalization. However, relative impact humoral cellular on protection from breakthrough infection is not fully understood.In a study cohort 655 primarily older participants (median 63 years (IQR: 51-72)), we determined serum levels Spike IgG antibodies using Multiantigen Serological Assay quantified frequency...
ObjectivesEvaluate six commercial serological assays for detection of IgA, IgM or IgG SARS-CoV-2 antibodies in different disease severities.MethodsThree lateral flow tests (LFTs) (Acro IgM/IgG, CTK Livzon IgM/IgG) and three ELISA (Euroimmun IgA IgG, Wantai IgM) were included. Application was evaluated using samples from 57 patients with a positive reverse transcription polymerase chain reaction, stratified according to severity. Specificity assessed historical 200 blood donors.ResultsWhile...
Background Viral meningitis (VM) is often perceived as mild and self-limiting, but some studies indicate reduced ability to work cognitive sequelae post-infection.
The accuracy of self-assessment has been questioned in studies comparing physicians' self-assessments to observed assessments; however, none these used self-efficacy as a method for self-assessment. aim the study was investigate how medical students' perceived specific communication skills corresponds evaluation simulated patients and observers. All students who signed up an Objective Structured Clinical Examination (OSCE) were included. As part OSCE, student performance "parent-physician...
Background and aims Chronic hepatitis C virus (HCV) genotype 3 infection with advanced liver disease has emerged as the most challenging to treat. We retrospectively assessed treatment outcome of sofosbuvir (SOF) based regimes for HCV infections in a real life setting Scandinavia. Methods Consecutive patients chronic were enrolled at 16 centers Denmark, Sweden, Norway Finland. Patients who had received SOF containing regimen included. The fibrosis stage was evaluated by biopsy or transient...
Background Chronic hepatitis C (CHC) can be eliminated as a public health threat by meeting the WHO targets: 90% of patients diagnosed and 80% treated 2030. To achieve monitor progress towards elimination, an updated estimate size CHC population is needed, but Denmark has no complete national register. By combining existing registers in 2007, we estimated living with to 16,888 (0.38% adult population). Aim undiagnosed on 31 December 2016. Among additional aims were proportion attending...
SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring immunological requirements for protection against breakthrough infection. The test-negative matched case-control study (N = 964) characterized infections triple-vaccinated individuals from ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower cases compared to controls (GMR [95% CI] BA.2: 0.83 [0.73-0.95], p 0.006)....
To evaluate the experience with use of sotrovimab following severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in high-risk groups.In a nationwide, population-based cohort study, we identified all individuals treated (N = 2933) and stratified them by 4 groups: (A) malignant haematological disease, (B) solid organ transplantation, (C) anti-CD20 therapy ≤1 year (D) other risks. Cox regression analysis was used to calculate hazard ratios for hospitalization, death associated...
AbstractAbstractBackground The goal of the C-Free-South project is to eliminate hepatitis C (HCV) in Region Southern Denmark (1.2 million inhabitants). One target group consists people with HCV who had received care but were lost follow-up. study aim was evaluate program efficacy locating these patients and getting them into care.Methods Patients contacted if they HCV-RNA positive age 18+ years, registered clinical database as November 1, 2019, no scheduled HCV-related appointment. They at...
Introduction Injecting drug use is the primary driver of hepatitis C virus (HCV) infection in Europe. Despite need for more engagement with care, people who inject drugs (PWID) are hard to reach HCV testing and treatment. We initiated a study evaluate efficacy linkage care among PWID consulting peer-based at mobile clinic Copenhagen, Denmark. Methods analysis In this intervention study, we will recruit participants single community-based, peer-run clinic. visit, first offer point-of-care...
Globally, many people with hepatitis C virus (HCV) infection are marginalized and have very limited access to traditional healthcare services, including HCV testing treatment. Models of care attuned the needs population at risk needed. This study aimed evaluate treatment uptake a community-based, peer-led model offering point-of-care testing.In this interventional cohort study, were recruited between May 2019 December 2021 mobile clinic. During single visit, participants offered antibody...
Within a year of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, vaccines inducing robust humoral and cellular immune response were implemented worldwide. However, emergence novel variants waning vaccine-induced immunity led to implementation additional vaccine boosters.