A5089536645- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Herpesvirus Infections and Treatments
- Vector-borne infectious diseases
- Infectious Diseases and Tuberculosis
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Vectors
- Otolaryngology and Infectious Diseases
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Streptococcal Infections and Treatments
- Mosquito-borne diseases and control
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Long-Term Effects of COVID-19
- Dermatological diseases and infestations
- Cytomegalovirus and herpesvirus research
- Autoimmune Neurological Disorders and Treatments
- COVID-19 and healthcare impacts
- Peripheral Neuropathies and Disorders
- Case Reports on Hematomas
- Cerebrospinal fluid and hydrocephalus
- Reproductive tract infections research
- Vector-Borne Animal Diseases
European Society of Clinical Microbiology and Infectious Diseases
2021-2025
Aalborg University Hospital
2016-2025
Aalborg University
2014-2025
Brain (Germany)
2025
Evangelisches Krankenhaus Göttingen-Weende
2024
Zealand University Hospital
2023
Odense University Hospital
2021-2023
Nordsjællands Hospital
2021-2023
Rigshospitalet
2021-2023
Aarhus University Hospital
2013-2023
Abstract Objective To determine the incidence of hospital admissions and associated mortality rates for non-covid medical conditions during covid-19 pandemic. Design Nationwide, population based cohort study. Setting Denmark from 13 March 2019 to 27 January 2021. Participants All Danish residents >1 year age. Main outcomes measures Population healthcare registries that encompass entire were used compare admission pandemic (from 11 2020 2021) with prepandemic baseline data 10 2020)....
SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk breakthrough infection in a fully vaccinated cohort. anti-spike IgG levels were measured before first vaccination at day 21-28, 90 180, as well after booster vaccination. Breakthrough infections captured through Danish National Microbiology database. incidence rate ratio (IRR) for time-updated was determined using Poisson regression. Among...
Community-acquired bacterial meningitis (CABM) is a life-threatening disease and timing of antibiotic therapy remains crucial. We aimed to analyse the impact on outcome CABM in contemporary cohort.We conducted population-based cohort study based chart reviews all adult cases (>16 years age) North Denmark from 1998 2014 excluding patients given pre-hospital parenteral antibiotics. used modified Poisson regression analyses compute adjusted risk ratio (adj. RR) with 95 % confidence intervals...
There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought compare the effectiveness standard care (SOC) alone versus SOC plus dexamethasone.Two population-based nationwide cohorts individuals hospitalized COVID-19 during February through December 2020 were studied. Death within 30 days need mechanical ventilation (MV) compared by inverse probability treatment...
To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and the durability of vaccine-induced antibodies.Adults without history SARS-CoV-2 infection from Danish population scheduled for vaccination were enrolled in this parallel group, phase 4 study. Spike IgG Spike-ACE2-receptor-blocking antibodies measured at days 0, 21, 90, 180. Vaccine was categorized according to levels day 90 after first vaccination. Nondurable response defined as day-90...
Older age and chronic disease are important risk factors for developing severe COVID-19. At population level, vaccine-induced immunity substantially reduces the of COVID-19 hospitalization. However, relative impact humoral cellular on protection from breakthrough infection is not fully understood.In a study cohort 655 primarily older participants (median 63 years (IQR: 51-72)), we determined serum levels Spike IgG antibodies using Multiantigen Serological Assay quantified frequency...
Clinical features applicable to the entire spectrum of viral meningitis are limited, and prognostic factors for adverse outcomes undetermined. This nationwide population-based prospective cohort study included all adults with presumed microbiologically confirmed in Denmark from 2015 until 2020. Prognostic an unfavourable outcome (Glasgow Outcome Scale score 1-4) 30 days after discharge were examined by modified Poisson regression. In total, 1066 episodes included, yielding a mean annual...
<h3>Abstract</h3> <h3>Objective</h3> To estimate long term survival, health, and educational/social functioning in patients with Lyme neuroborreliosis compared the general population. <h3>Design</h3> Nationwide population based cohort study using national registers. <h3>Setting</h3> Denmark. <h3>Participants</h3> All Danish residents diagnosed during 1986-2016 as having (n=2067), defined a positive <i>Borrelia burgdorferi</i> intrathecal antibody test clinical diagnosis of borreliosis,...
Knowledge of the epidemiology and clinical characteristics varicella zoster virus (VZV) encephalitis remains limited.Nationwide prospective cohort study adults treated for microbiologically confirmed VZV at Danish departments infectious diseases from 2015 to 2019. Modified Poisson regression analysis was used compute adjusted relative risks (RRs) unfavorable outcome.We identified 92 (49% female) with encephalitis, yielding an incidence 5.3/1 000 per year (95% CI, 4.2-6.6). Median age 75...
We aimed to determine the long-term risks of mortality and new-onset epilepsy after brain abscess.Using nationwide population-based medical registries, we examined all patients with first-time abscess in Denmark, 1982-2016. Comparison cohorts individually matched on age, sex, residence were identified, as siblings study participants. Next, computed cumulative incidences hazard rate ratios (HRRs) 95% confidence intervals among populations.We identified 1384 (37% females) a median follow-up...
Abstract Background Knowledge on risk factors for brain abscess is limited and relies single-center cohort studies. Methods We accessed nationwide medical registries to conduct a population-based, nested case-control study of abscess. applied risk-set sampling the selection population controls (1:10), who were individually matched by age, sex, area residence. Conditional logistic regression was used compute adjusted odds ratios (aOR) with 95% confidence intervals (CIs)....
Abstract Background Venous thromboembolism (VTE) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and thromboprophylaxis should be balanced against risk bleeding. This study examined risks VTE major bleeding in hospitalized community-managed SARS-CoV-2 patients compared with control populations. Methods Using nationwide population-based registries, 30-day positive were those test-negative an external cohort influenza patients....
Studies on brain abscess are hampered by single-centre design with limited sample size and incomplete follow-up. Thus, robust analyses clinical prognostic factors remain scarce. This Danish nationwide, population-based cohort study included details of all adults (≥18 years) diagnosed in the National Patient Registry from 2007 through 2014 prospective database Study Group Infections Brain covering departments infectious diseases 2015 2020. All patients were followed for 6 months after...
Abstract Background With artificial intelligence (AI) on the rise, it remains unclear if AI is able to professionally evaluate medical research and give scientifically valid recommendations. Aim This study aimed assess accuracy of ChatGPT’s responses ten key questions brain abscess diagnostics treatment in comparison guideline recently published by European Society for Clinical Microbiology Infectious Diseases (ESCMID). Methods All PECO (Population, Exposure, Comparator, Outcome) which had...
Stroke is a serious complication in community-acquired bacterial meningitis (CABM), but the incidence, predispositions, and outcome need further clarification; this pertains particular to impact of pre-existing atherosclerosis risk factors. Therefore, we aimed assess these features retrospective population-based cohort study.We included all patients over 16 years age with CABM North Denmark Region, 1998-2010. All data were retrieved from patient records. A Glasgow Outcome Scale score 1-4 was...
<h3>Importance</h3> Coagulopathy may deter physicians from performing a lumbar puncture. <h3>Objective</h3> To determine the risk of spinal hematoma after puncture in patients with and without coagulopathy. <h3>Design, Setting, Participants</h3> Danish nationwide, population-based cohort study using medical registries to identify persons who underwent had cerebrospinal fluid analysis (January 1, 2008-December 31, 2018; followed up through October 30, 2019). was defined as platelets lower...
Abstract Background Death from bacterial meningitis is rarely attributed to the actual event causing death. The present study therefore categorized and characterized cause time of death due meningitis. Methods In a cohort patients > 15 years age with community acquired medical records were reviewed, clinical into six main categories: 1) CNS complications, 2) Systemic 3) Combination systemic 4) Sudden death, 5) Withdrawal care, or 6) Unknown. Results We identified 358 which 84 (23%) died...
Epilepsy in patients with brain abscess is frequent, but risk factors and prognosis remain undetermined. This study examined of epilepsy among survivors associated prognosis.Nationwide, population-based healthcare registries were used to compute cumulative incidences cause-specific adjusted hazard rate ratios (adj. HRRs) 95% CIs for 30-day from 1982 through 2016. Data enriched clinical details by medical record review hospitalized 2007 Adjusted mortality MRRs) using as a time-dependent...