A5009934396- Bone health and osteoporosis research
- Bone health and treatments
- Anesthesia and Pain Management
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Parathyroid Disorders and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Body Composition Measurement Techniques
- Medical Imaging and Analysis
- Vector-borne infectious diseases
- Thyroid Cancer Diagnosis and Treatment
- Nausea and vomiting management
- DNA and Nucleic Acid Chemistry
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Vectors
- Bacterial Genetics and Biotechnology
- Nutrition and Health in Aging
- Viral Infections and Immunology Research
- Pharmacological Effects and Toxicity Studies
- Rheumatoid Arthritis Research and Therapies
- Drilling and Well Engineering
- Thyroid and Parathyroid Surgery
- Herpesvirus Infections and Treatments
Rigshospitalet
1985-2021
Nordsjællands Hospital
2017-2021
University of Copenhagen
1987-2021
Nordic Bioscience (Denmark)
2007-2021
Copenhagen University Hospital
2012-2021
Bioscience Research
2020
Gentofte Hospital
2013
Center for Clinical & Basic Research
1996-2012
Intensive Care Society
2012
Centre for Inflammation Research
2012
Reducing bisphosphonate dosing frequency may improve suboptimal adherence to treatment and therefore therapeutic outcomes in postmenopausal osteoporosis. Once-monthly oral ibandronate has been developed overcome this problem.To confirm the 1 year results provide more extensive safety tolerability information for once-monthly by a 2 analysis.MOBILE, randomised, phase III, non-inferiority study, compared efficacy of with daily ibandronate, which previously shown reduce vertebral fracture risk...
<h3>Background</h3> Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis. <h3>Methods</h3> Patients with osteoarthritis (Kellgren and Lawrence grade 2 or 3, joint space width (JSW) 2.5–5 mm) were randomly allocated to strontium 1 g/day (n=558), (n=566) placebo (n=559). primary endpoint was radiographical change JSW...
An enzyme-linked immunosorbent assay (ELISA) for measuring type I collagen degradation products in urine < 3 h was evaluated. The range 0.5-10.5 mg/L with a detection limit of 0.2 mg/L. Within-run and total CVs were 5.3% 6.6%, respectively. Analytical recovery averaged 100%. mean (+/- SD) concentrations samples from healthy premenopausal population (n = 102) 250 +/- 110 mg/mol creatinine (Cr). A group postmenopausal women 410) gave value 416 189 Cr. Values obtained the ELISA correlated well...
To investigate the association between urinary concentrations of C-telopeptide fragments type II collagen (CTX-II) and prevalence progression radiographic osteoarthritis (OA) knee hip.The study population consisted a sample 1,235 men women ages > or =55 years who were enrolled in Rotterdam Study (a population-based cohort study) followed up for mean 6.6 years. Prevalent OA was defined as Kellgren/Lawrence score =2; decrease joint space width.Subjects with CTX-II level highest quartile had...
We present a fully automatic method for articular cartilage segmentation from magnetic resonance imaging (MRI) which we use as the foundation of quantitative assessment. evaluate our by comparisons to manual segmentations radiologist and examining interscan reproducibility volume area estimates. Training evaluation is performed on data set consisting 139 scans knees with status ranging healthy severely osteoarthritic. This is, knowledge, only that has good agreement segmentations, an human...
The serum magnesium concentration was measured in 71 insulin-treated diabetic outpatients who had the disease for 10 to 20 years. patients were divided into two subgroups according severity of their retinopathy. As a whole exhibited definite hypomagnesemia (P less than 0.001) that most pronounced subgroup having severest degree retinopathy 0.01). comparable regarding known risk factors implicated Thus, appears be an additional factor development and progress this complication.
Estrogen deficiency has been implicated as a risk factor for cognitive impairment in elderly women, yet the role of hormone therapy (HT) to prevent this event remains controversial. The aim study was investigate impact administration HT 2 3 years early postmenopausal on 5 15 later.We followed group 343 women who had received randomized, placebo-controlled trials and were reexamined 5, 11, or after completion therapy. Of these 261 either placebo during with no further treatment until...
Perivascular axillary blockade was performed on 150 patients with the aid of a catheter technique. Blockade failure due to injection outside neurovascular sheath found in 5.7% subject material. The were randomly allocated three groups. amount local anaesthetic constant each group: 400 mg mepivacaine adrenaline. However, injected volume variable factor, namely 20, 40 or 80 ml. Sensory and motor tested 30 min after injection. following results obtained: 1) Apart from axillary, musculocutaneous...
The long-term reproducibility of bone mineral content (BMC) measurements using two identical equipments for two-dimensional fore-arm scanning, was measured in normal persons and aluminium standards (corresponding to severely osteopenic patients). mean coefficient variation subjects one year 1·4%. data were used estimate that this equipment can measure BMC patients with a long term 1·7%, which is sufficient use the clinically relevant range calcium balance.
Arzoxifene is a selective estrogen receptor modulator (SERM) that has been shown to be more potent in preclinical testing than currently available agents. Its effects on clinical outcomes are not known. In randomized, blinded trial, women aged 60 85 years with osteoporosis, defined as femoral neck or lumbar spine bone mineral density T-score of -2.5 less vertebral fracture, and low mass, -1.0 above -2.5, were assigned arzoxifene 20 mg placebo daily. The primary endpoints new fracture those...
In a prospective clinical study including 100 patients, the consequences of using interscalene approach to block brachial plexus were investigated according area analgesia, complications, and blood concentrations local anesthetics. Sufficient analgesia shoulder upper part arm was obtained in 98-99% cases, whilst forearm hand more variable. two groups, with 10 patients each group, concentration measured during first 50 min after injection neurovascular sheath by either or axillary approach....
The effects of neurogenic block on plasma concentrations adrenaline, noradrenaline and cyclic AMP were studied. Eighteen patients subjected to surgery moderate or minor extent under enflurance anesthesia with without epidural analgesia. results show that adrenaline secretion during surgical stress is a response stimuli, since the increase found in hysterectomy general blocked by addition Furthermore, after comparable levels stress. concentration does not correlate trauma. In contrast levels,...
<h3>Abstract</h3> <h3>Objective</h3> To estimate long term survival, health, and educational/social functioning in patients with Lyme neuroborreliosis compared the general population. <h3>Design</h3> Nationwide population based cohort study using national registers. <h3>Setting</h3> Denmark. <h3>Participants</h3> All Danish residents diagnosed during 1986-2016 as having (n=2067), defined a positive <i>Borrelia burgdorferi</i> intrathecal antibody test clinical diagnosis of borreliosis,...
From June 2014 through February 2015, respiratory samples from 130 Danish patients were screened for enterovirus D68 (EV-D68). Fourteen EV-D68 cases detected, of which 12 presented with symptoms, and eight had known underlying disease. The median age was three years (interquartile range: 0–30 years). Acute flaccid paralysis (AFP) not detected although strains showed > 98% nt identity EV-D68-strains AFP the United States France.