A5018629815- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Neonatal and Maternal Infections
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Nosocomial Infections in ICU
- COVID-19 diagnosis using AI
- COVID-19 and Mental Health
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Thermal Regulation in Medicine
- Burkholderia infections and melioidosis
- Proteoglycans and glycosaminoglycans research
- Polyomavirus and related diseases
- Streptococcal Infections and Treatments
- Immune responses and vaccinations
- Inflammatory Biomarkers in Disease Prognosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Meta-analysis and systematic reviews
Örebro University
2013-2024
Örebro University Hospital
2012-2024
Reduced monocyte human leukocyte antigen (mHLA)-DR surface expression in the late phase of sepsis is postulated as a general biomarker sepsis-induced immunosuppression and an independent predictor nosocomial infections. However, traditional monitoring mHLA-DR by flow cytometry has disadvantages due to specific laboratory requirements. An mRNA-based HLA-DR polymerase chain reaction (PCR) would improve clinical usage facilitate conduction large multicenter studies. In this study, we evaluated...
Background The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms reduced health-related quality life (HRQoL) in relation functional exercise capacity, 6 months infection, explored risk factors for sequalae. Methods This was prospective, multicenter, cohort study including 434 patients. At months, physical capacity assessed by 1-minute sit-to-stand test (1MSTST) were...
Abstract Background Severe COVID‐19 increases the risk for long‐term respiratory impairment, but data after mild are scarce. Our aims were to determine factors reduced function 3–6 months infection and investigate if would relate impairment of exercise performance breathlessness. Methods Patients with enrolled at University Hospitals Umeå Örebro, Karlstad Central Hospital, Sweden. Disease severity was defined as (nonhospitalized), moderate (hospitalized or without oxygen treatment), severe...
mRNA vaccines are likely to become widely used for the prevention of infectious diseases in future.Nevertheless, a notable gap exists mechanistic data, particularly concerning potential effects sequential immunization or preexisting immunity on early innate immune response triggered by vaccination.In this study, healthy adults, with without documented prior SARS-CoV-2 infection, were vaccinated BNT162b2/Comirnaty vaccine.Prior infection conferred significantly stronger induction...
The mechanisms underlying Post COVID-19 condition (PCC), with its range of long-lasting symptoms, remain unclear. This study investigates DNA methylation patterns over one year in a subset non-hospitalized patients persistent symptoms and reduced quality life, termed PCC+ (Post plus). In cohort 22 individuals matched convalescents (PCC-), we identified distinct differences between the groups that diminish time. Methylation changes TXNRD1 gene were significantly associated cognitive fatigue,...
Introduction A decrease in the expression of monocyte surface protein HLA-DR (mHLA-DR), measured by flow cytometry (FCM), has been suggested as a marker immunosuppression and negative outcome severe sepsis. However, FCM is not always available due to sample preparation that limits its use laboratory operational hours. In this prospective study we evaluated dynamic changes mHLA-DR during sepsis relation HLA-DRA gene Class II transactivator (CIITA), quantitative Real-Time Polymerase Chain...
ABSTRACT We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting hyaluronan (HA). In this translational study, we investigated role HA at all stages disease to map consequences elevated on morbidity and identify mechanism severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced production. A reduced alveolar surface area was observed in compared healthy controls, as visualized by 3D rendering lung morphology using...
Staphylococcus aureus bacteraemia is a disease with varying presentation, ranging from uncomplicated to life-threatening infections. In S. bacteraemia, high load of bacterial DNA in blood has been linked mortality. We hypothesized that would also be the presence sepsis, and C-reactive protein (CRP) lymphopaenia, indicating inflammation immunosuppression.Twenty-seven patients culture-proven 13 (48%) sepsis six (22%) non-survivors, were enrolled prospective study. Blood samples collected on...
Objective In the pathogenesis of sepsis, activation both pro- and anti-inflammatory responses are key components, but knowledge is lacking on association between bacterial etiology development dysregulated with sustained immunosuppression. The aim this study was to evaluate how immunosupression marker HLA-DR monocytes (mHLA-DR) associated markers inflammation during clinical trajectory bloodstream infection (BSI). Methods Ninety-one adults, predominantly non-ICU patients, BSI caused by...
Background Chest CT is prognostic in Covid-19 but there a lack of consensus on how to report the findings. A chest scoring system, ÖCoS, was implemented clinical routine 1 April 2020, Örebro Region, Sweden. The ÖCoS-severity score measures extent lung involvement. objective study evaluate ÖCoS scores as predictors course Covid-19.
Damage-associated molecular patterns (DAMPs) and pathogen-associated (PAMPs) are key triggers of inflammation in sepsis. However, they have rarely been studied simultaneously. Thus, the present study patients with bacteraemic infection, we aimed to how DAMP dynamics linked disease severity outcome compare diagnostic prognostic properties a previously analysed PAMP (16S rDNA). In prospective adult hospitalized culture-proven community-onset caused by Streptococcus pneumonia (n = 30),...
Abstract Background Blood stream infection (BSI) and sepsis are serious clinical conditions identification of the disease-causing pathogen is important for patient management. The RISE (Rapid Identification SEpsis) study was carried out to collect a cohort allowing high-quality studies on different aspects BSI sepsis. aim this identify patients at high risk who might benefit most from new, faster, etiological testing using neutrophil lymphocyte count ratio (NLCR) Shapiro score. Methods Adult...
The World Health Organization has adopted a resolution on sepsis and urged member states to develop national processes improve care. In Sweden, was selected as one of the ten first diagnoses be addressed, when Swedish government in 2019 allocated funds for patient-centred clinical pathways healthcare. A multidisciplinary working group, including patient representative, appointed pathway sepsis.The group mapped challenges needs surrounding care included survey sent all emergency departments...
Objective The aim of the study was to infection, hospitalization, and admission intensive care unit for COVID-19 in different occupations pandemic waves a Swedish county. Methods Individual registry data infection hospitalization were merged with occupational this cross-sectional study. Infected, hospital-, unit-admission analyzed by groups. Results 22,095 cases from 21 February 2020 31 August 2022 identified. Healthcare workers others working close physical proximity showed higher rate...
Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads severe COVID-19. Cold-inducible RNA-binding protein (CIRP), newly identified DAMP aggravates inflammation and tissue injury, induces respiratory failure in sepsis. Whether CIRP contributes pathogenesis COVID-19 has not yet been explored. Aim To investigate if concentration extracellular (eCIRP) serum associates with lung involvement by...
Objective We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 influenza in patients presenting myocardial infarction (MI) without COVID-19 symptoms. Methods conducted an observational study from 28 June 11 August 2020, enrolling admitted National Institute Cardiovascular Disease Hospital, Dhaka, Bangladesh, ST-segment elevation MI (STEMI) or non-ST-segment who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab test...
The severity of bloodstream infections (BSI) depends on pathogen, source, and host factors. Secretory leukocyte protease inhibitor (SLPI) counteracts tissue damage, balances inflammation, is increased in pneumonia sepsis. We aimed to evaluate whether SLPI production differs depending etiology, disease severity, sex BSI correlate with markers inflammation immunosuppression. Of the adult patients BSI, 109 were included sampled repeatedly, from hospital admission through day 28. Controls (blood...