A5051223877- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Respiratory viral infections research
- Respiratory Support and Mechanisms
- Antibiotic Use and Resistance
- Thermal Regulation in Medicine
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- COVID-19 and Mental Health
- Central Venous Catheters and Hemodialysis
- Global Maternal and Child Health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Bacterial Identification and Susceptibility Testing
- Psychosomatic Disorders and Their Treatments
- Epigenetics and DNA Methylation
- Sphingolipid Metabolism and Signaling
- Olfactory and Sensory Function Studies
- Lipid Membrane Structure and Behavior
- Pediatric health and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Emergency and Acute Care Studies
Umeå University
2015-2024
Background: Standard diagnostic methods for lower respiratory tract infections are currently too slow and insensitive to guide early clinical decisions concerning treatment isolation. Syndrome-specific, panels have potential provide information about aetiology quickly. Available been of limited use in due turn-around-time, lack quantification important pathogens detection resistance genes.Materials/methods: We evaluated the newly developed Biofire® Filmarray® Pneumonia Panel plus...
Background The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms reduced health-related quality life (HRQoL) in relation functional exercise capacity, 6 months infection, explored risk factors for sequalae. Methods This was prospective, multicenter, cohort study including 434 patients. At months, physical capacity assessed by 1-minute sit-to-stand test (1MSTST) were...
Abstract Background Severe COVID‐19 increases the risk for long‐term respiratory impairment, but data after mild are scarce. Our aims were to determine factors reduced function 3–6 months infection and investigate if would relate impairment of exercise performance breathlessness. Methods Patients with enrolled at University Hospitals Umeå Örebro, Karlstad Central Hospital, Sweden. Disease severity was defined as (nonhospitalized), moderate (hospitalized or without oxygen treatment), severe...
The mechanisms underlying Post COVID-19 condition (PCC), with its range of long-lasting symptoms, remain unclear. This study investigates DNA methylation patterns over one year in a subset non-hospitalized patients persistent symptoms and reduced quality life, termed PCC+ (Post plus). In cohort 22 individuals matched convalescents (PCC-), we identified distinct differences between the groups that diminish time. Methylation changes TXNRD1 gene were significantly associated cognitive fatigue,...
A metabolomics approach for prediction of bacteremic sepsis in patients the emergency room (ER) was investigated. In a prospective study, whole blood samples from 65 with and 49 ER controls were compared. The analyzed using gas chromatography coupled to time-of-flight mass spectrometry. Multivariate logistic regression modeling metabolites identified by or conventional laboratory parameters clinical scores infection employed. predictive model 107 developed validated. number reduced stepwise...
Phospholipids, major constituents of bilayer cell membranes, are present in large amounts pulmonary surfactant and play key roles signaling. Here, we aim at finding clinically useful disease markers community-acquired pneumonia (CAP) using comprehensive phospholipid profiling blood modeling changes between sampling time points. Serum samples from 33 patients hospitalized with CAP were collected admission, three hours after the start intravenous antibiotics, Day 1 (at 12–24 h), 2 36–48...
Abstract Background Olfactory dysfunction together with neurological and cognitive symptoms are common after COVID‐19. We aimed to study whether performance on olfactory neuropsychological tests following infection predict post‐COVID condition (PCC), persisting symptoms, reduced health‐related quality of life. Methods Both hospitalized (N = 10) non‐hospitalized individuals 56) were enrolled in this prospective cohort study. Participants evaluated 1–3 months an threshold test tests, which was...
Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads severe COVID-19. Cold-inducible RNA-binding protein (CIRP), newly identified DAMP aggravates inflammation and tissue injury, induces respiratory failure in sepsis. Whether CIRP contributes pathogenesis COVID-19 has not yet been explored. Aim To investigate if concentration extracellular (eCIRP) serum associates with lung involvement by...
ABSTRACT Background We have previously shown that lungs from deceased COVID-19 patients are filled with hyaluronan (HA). In this translational study, we investigated the role of HA in all stages disease, to map consequences elevated morbidity and identify mechanism SARS-CoV-2-induced production. Methods Lung morphology was visualized 3D using light-sheet fluorescence microscopy. verified by immunohistochemistry, fragmentation determined gas-phase electrophoretic molecular mobility analysis....
Background: The long-term sequelae after COVID-19 constitute a challenge to public health and increased knowledge is needed. We investigated the prevalence of self-reported persistent symptoms reduced health-related quality life (HRQoL) in relation functional exercise capacity, six months infection, explored risk factors for sequalae.Methods: This was prospective, multicentre, cohort study including 434 patients. At 6 months, physical capacity assessed by 1-minute sit-to-stand test (1MSTST)...