A5020930578- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Vitamin C and Antioxidants Research
- Hepatitis C virus research
- T-cell and B-cell Immunology
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
Aarhus University Hospital
2017-2023
Aarhus University
2023
BackgroundUpon SARS-CoV-2 infection, most individuals develop neutralizing antibodies and T-cell immunity. However, some reportedly remain PCR positive by pharyngeal swabs weeks after recovery. Whether viral RNA in these persistent carriers is contagious stimulates SARS-CoV-2-specific immune responses unknown.MethodsThis cohort study was conducted between April 3rd–July 9th 2020, recruiting COVID-19 recovered that were symptom-free for at least 14 days. We collected serum total Ig, IgA IgM...
This was an exploratory, single-arm clinical trial that tested the immune enhancement effects of 24-weeks Toll-like receptor 9 (TLR9) agonist (MGN1703; Lefitolimod; 60 mg × 2 weekly) therapy.We enrolled HIV-1-infected individuals on suppressive combination antiretroviral therapy. Safety assessed throughout study. The primary outcome reduction in total CD4 T-cell viral DNA levels. Secondary outcomes included safety, detailed immunological and virological analyses, time to rebound (viral load...
The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of infections and aid search evaluation new treatment modalities vaccines, comprehensive characterization adaptive immune responses towards is needed.
Human plasmacytoid dendritic cells (pDCs) play a central role in initiating and activating host immune responses during infection. To understand how the transcriptome of pDCs is impacted by HIV-1 infection exogenous stimulation, we isolated from healthy controls, people with (PWH) before toll-like receptor 9 (TLR9) agonist treatment performed single-cell (sc)-RNA sequencing. Our cluster analysis revealed four pDC clusters: pDC1, pDC2, cytotoxic-like an exhausted cluster. The inducible...
Abstract The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of infections and aid search for treatments vaccines, comprehensive characterization adaptive immune responses towards is needed. We investigated breadth potency antibody-, T-cell responses, in 203 recovered infected patients who presented with asymptomatic to severe infections. report very broad serological profiles cross-reactivity other human coronaviruses. Further, >99% had epitope...
Genetic polymorphisms at the IFNL4 loci are known to influence clinical outcome of several different infectious diseases. Best described is association between genotype and hepatitis C virus clearance. However, an on adaptive immune system was suggested by studies but never investigated in humans. In this cross-sectional study, we have genotyped 201 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive participants for 3 (rs368234815, rs12979860, rs117648444) stratified them...