A5029128446- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- COVID-19 diagnosis using AI
- Vaccine Coverage and Hesitancy
- Gut microbiota and health
- Neutropenia and Cancer Infections
- Mycobacterium research and diagnosis
- vaccines and immunoinformatics approaches
- COVID-19 and healthcare impacts
- Hematopoietic Stem Cell Transplantation
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
- Oral health in cancer treatment
- Technology and Human Factors in Education and Health
- Heart Rate Variability and Autonomic Control
- Machine Learning in Healthcare
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Peripheral Neuropathies and Disorders
- Transplantation: Methods and Outcomes
- Neuropeptides and Animal Physiology
- Information Systems and Technology Applications
- Intensive Care Unit Cognitive Disorders
Research Institute of Influenza
2020-2023
European University at Saint Petersburg
2021-2023
First Pavlov State Medical University of St. Petersburg
2018-2022
ITMO University
2022
Abstract Evolution of SARS-CoV-2 in immunocompromised hosts may result novel variants with changed properties. While escape from humoral immunity certainly contributes to intra-host evolution, cellular is poorly understood. Here, we report a case long-term COVID-19 an patient non-Hodgkin’s lymphoma who received treatment rituximab and lacked neutralizing antibodies. Over the 318 days disease, genome gained total 40 changes, 34 which were present by end study period. Among acquired mutations,...
This study is a successor of our previous work concerning changes in the chemokine profile infection that are associated with different SARS-CoV-2 genetic variants. The goal was to take into account both virus and host immune system by assessing concentrations cytokines patients infected variants (ancestral Wuhan strain, Alpha, Delta Omicron). Our performed on 340 biological samples taken from COVID-19 healthy donors timespan between May 2020 April 2022. We genotyping nasopharyngeal swabs,...
The adaptive antiviral immune response requires interaction between CD8+ T cells, dendritic and Th1 cells for controlling SARS-CoV-2 infection, but the data regarding role of in acute phase COVID-19 post-COVID-19 syndrome are still limited.. Peripheral blood samples collected from patients with (n = 71), convalescent subjects bearing serum N-protein-specific IgG antibodies 51), healthy volunteers no detectable to any proteins (HC, n 46) were analyzed using 10-color flow cytometry.Patients...
IgG is the most prominent marker of post-COVID-19 immunity. Not only does this subtype mark late stages infection, but it also stays in body for a timespan at least 6 months. However, different subclasses have properties, and their roles specific anti-COVID-19 responses yet to be determined. We assessed concentrations IgG1, IgG2, IgG3, IgG4 against SARS-CoV-2 antigens (N protein, S protein RBD) using specifically designed method samples from 348 COVID-19 patients. noted statistically...
Infection caused by SARS-CoV-2 mostly affects the upper and lower respiratory tracts causes symptoms ranging from common cold to pneumonia with acute distress syndrome. Chemokines are deeply involved in chemoattraction, proliferation, activation of immune cells within inflammation. It is crucial consider that mutations virion can potentially affect clinical course infection because disease severity manifestation vary depending on genetic variant. Our objective was measure assess different...
COVID-19, an infection caused by the new coronavirus SARS-CoV-2, is associated with a number of pathophysiological mechanisms, mobilizing wide spectrum biomolecules, mainly, cytokines. The purpose this study was to evaluate levels multiple cytokines in blood plasma from patients COVID-19 during acute phase disease, and upon complete recovery. Samples peripheral 56 69 convalescents 10 healthy individuals were examined. Concentrations 46 molecules, such as IL-1α, IL-1β, IL-2, IL-3, IL-4, IL-5,...
Background Results of a randomised trial showed the safety and efficacy Gam-COVID-Vac against COVID-19. However, compared to other vaccines used across globe, real-world data on effectiveness Gam-COVID-Vac, especially disease caused by Delta variant concern, was not available. We aimed assess vaccination mainly conducted with in St. Petersburg, Russia. Methods designed case-control study vaccine (VE) lung injury referral hospital. Self-reported status collected for individuals confirmed...
In our study, we aimed to evaluate the significance of specific cytokines in blood plasma as predictive markers COVID-associated mortality. Materials and methods. samples 29 patients with PCR-confirmed COVID-19 measured concentrations 47 molecules. These molecules included: interleukins selected pro-inflammatory (IL-1, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-12 (p40), (p70), IL 13, IL-15, IL-17A/CTLA8, IL-17-E/IL-25, IL-17F, IL-18, IL-22, IL-27, IFN2, IFN, TNF,...
Aim.Was to evaluate clinical efficacy, adverse events and changes in the gut microbiome after fecal microbiota transplantation (FMT) patients with gastrointestinal (GI) form of graft-versus-host disease (GVHD). Materials methods.The prospective single-center study R.M. Gorbacheva institute included 27 GI GVHD allogeneic stem cell transplantation. 19 received FMT, 8 placebo. Clinical scales for autoimmune diseases were used response. Microbiome alterations assessed multiplex PCR....
Abstract Background The results of a randomised trial showed the safety and efficacy Gam-COVID-Vac against COVID-19. However, compared to other vaccines used across globe, real-world data on effectiveness Gam-COVID-Vac, especially disease caused by Delta variant concern, was limited. We aimed assess vaccination mainly conducted with in St. Petersburg, Russia. Methods designed case-control study vaccine (VE) referral hospital. Self-reported status collected for individuals confirmed...
Abstract Evolution of SARS-CoV-2 in immunocompromised hosts may result novel variants with changed properties, but the mode selection underlying this process remains unclear. While escape from humoral immunity certainly plays a role intra-host evolution, cellular is poorly understood. Here, we report case long-term COVID-19 an patient non-Hodgkin’s lymphoma who received treatment rituximab and lacked neutralizing antibodies. Over 318 days disease, genome gained total 40 changes, 34 which...
Summary Fecal microbiota transplantation (FMT), as any other medical procedure, requires standardization of results, approaches, monitoring its dynamics and engraftment evaluation. The aim the present study was to compare efficiency results PCR 16S RNA-based sequencing in order trace composition after FMT. Patients methods prospective, single-center included 27 patients with acute intestinal chronic (overlap syndrome) graft-versus-host disease (GvHD) developed allogeneic hematopoietic stem...
Abstract Background Several anti-cytokine therapies were tested in the randomized trials hospitalized patients with severe acute respiratory syndrome coronavirus 2 infection (COVID-19). Previously, dexamethasone demonstrated a reduction of case-fatality rate failure. In this matched control study we compared to Janus kinase inhibitor, ruxolitinib. Methods The cohort included 146 COVID-19 and oxygen support requirement. group was selected 1:1 from 1355 dexamethasone-treated by main clinical...
Abstract Background Studies of mRNA and vector-based vaccines used in different countries report acceptable levels effectiveness against SARS-CoV-2 infection caused by the Delta variants SARS-CoV-2. No studies estimated vaccine (VE) Gam-COVID-Vac other Russia symptomatic with variant. In this population-based case-control study, we aimed to estimate Russian COVID-19 during recent outbreak VOC October 2021 St. Petersburg, Russia. Methods Cases were patients confirmed (using polymerase chain...
Over last years, an important role of altered gut microbiota and its potential correction was suggested for pediatric cancer autoimmune disorders.The data from decade highlight sufficient influence the main classes bacteria (Firmicutes Bacteroides) upon development immune response in oncological disorders autoagressive conditions, as well their imbalance using fecal transplantation (FMT) approach.Our previous studies have shown a pronounced clinical effect FMT, mostly, adult patients with...
Background Studies of mRNA and vector-based vaccines used in different countries report acceptable levels effectiveness against SARS-CoV-2 infection caused by the Delta variants SARS-CoV-2. No studies estimated vaccine (VE) Gam-COVID-Vac other Russia symptomatic with variant. In this population-based case-control study, we aimed to estimate Russian COVID-19 during recent outbreak VOC October 2021 St. Petersburg, Russia. Methods a study density sampling controls, acquired information on cases...
Purpose: The aim of this research is to develop an accurate and interpretable aggregated score not only for hospitalization outcome prediction (death/discharge) but also the daily assessment COVID-19 patient's condition. Patients Methods: In single-center cohort study, real-world data collected within first two waves pandemic was used (27.04.2020-03.08.2020 01.11.2020-19.01.2021, respectively). wave (1,349 cases) as a training set development, while second (1,453 validation set. No...
The disease caused by the highly contagious SARS-CoV-2 virus – “novel coronavirus infection (COVID-19)” had killed more than 6.5 million people at end of December 2022. severity manifestation infectious process varies from asymptomatic forms to rapid progression life-threatening conditions requiring emergency measures. One factors, which affects outcome disease, is lymphopenia, cause may be a violation lymphopoiesis. identification laboratory markers high risk mortality in patients with...
According to the WHO data, number of infected people exceeded 765.2 million during COVID-19 pandemic. The severity patient’s condition is determined by immune system hyperactivation. Activation T- and B-lymphocyte subsets plays a prominent role in control infectious process. A content small circular DNA molecules — T-cell receptor excision circles (TREC circles) B-cell (“kappa”) rings (KREC Kappa-deleting recombination peripheral blood can be used as marker functionally active T B cells...
Subjects and methods. The retrospective study included 37 patients ( n = 37) diagnosed with severe viral pneumonia SAR S -C oV2) who were treated in the intensive care unit of Pavlov First Saint Petersburg State Medical University. To assess significance PADM as a biomarker bacterial infection, divided into two groups: group without sepsis 24) those developed septic shock complicating course new coronavirus infection 13). was assessed criterion for severity disease groups deceased 19)...
Nicholas Brigham Adams, PhD (Sociology Data Science, UC Berkeley, 2015), founder of R D company for fighting misinformation, will discuss Independent Social Science with Oksana Stanevich from the Briva Universita and seminar guests - is it actually possible today? Topics include: How to avoid prevent becoming biased, they secure funding sociological research, combat misinformation in today's geopolitical climate, what tools Adams's his team can offer this, What Decentralized means sociology...
The mechanisms of development nosocomial infectious complications in COVID-19 and the contribution bacterial mycotic superinfection to formation extremely high mortality among patients with severe course this disease have not yet been fully revealed. objective: study epidemiology, risk factors for superinfection, its effect on severity outcome COVID-19. Subjects Methods . 383 cases were retrospectively analyzed. Demographic data, presence concomitant diseases, community-acquired co-infection...
Aim. To conduct a retrospective assessment of the clinical and laboratory data patients with severe forms COVID-19 hospitalized in intensive care unit, order to assess contribution various indicators likelihood death. Materials methods. A on 224 admitted unit was carried out. The analysis included biochemical, blood tests, coagulograms, inflammatory response. When transferring units (ICU), formalized SOFA APACHE scales were recorded. Anthropometric demographic downloaded separately. Results....