A5021756917- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Anesthesia and Neurotoxicity Research
- Healthcare Systems and Public Health
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Cardiac Arrest and Resuscitation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Sinusitis and nasal conditions
- Disaster Response and Management
- Long-Term Effects of COVID-19
- Acute Kidney Injury Research
- Medical History and Innovations
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Muscle and Compartmental Disorders
- Head and Neck Surgical Oncology
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
First Pavlov State Medical University of St. Petersburg
2016-2024
Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine
2018
Research Institute of Obstetrics and Gynecology named after D.O. Ott
2010
S. M. Kirov Military Medical Academy
2005
Strains of microorganisms characterized by resistance to antimicrobial drugs used in medical organizations continue spread In most regions the world including Russia. It is clear that it affects both effectiveness therapy and tactics strategy its use not only adults patients but also children. The pandemic coronavirus infection, addition, highlighted growing problems treatment invasive mycoses, dose adjustment antibiotics during sorption dialysis methods. These circumstances made necessary...
Clinical guidelines «Sepsis (in adults)» are an interdisciplinary document developed by 8 professional non-profit public organizations and approved the Scientific Practical Council of Ministry Health Russia. They intended to help doctors various specialties (anesthesiologist intensivist, surgeon, emergency physician, neurosurgeon, cardiovascular thoracic transfusiologist, orthopedic traumatologist, nephrologist, urologist, maxillofacial infectious disease clinical pharmacologist, medical...
Purpose . To evaluate the efficacy and safety of using a dynamic inversion table to improve vasomotor function microvasculature increase functional reserves in patients with post-COVID syndrome. Materials methods The study involved 70 aged 18 75 years (35 main group 35 control groups) history COVID-19 (confirmed), persistent complaints decrease quality life for more than 12 weeks after suffering disease. groups were formed by randomization. Patients received ten-day rehabilitation course...
Introduction. Strains of microorganisms resistant to antimicrobial agents are commonly found in medical units throughout most regions the world, including Russia. This leads lower therapy efficacy when treating nosocomial infections. In this regard, timely implementation adequate antibiotic is great importance. The objective guidelines: To provide summarized information on contemporary approaches microbiological diagnostics and assessment results, as well principles rational use antifungal...
In our study, we aimed to evaluate the significance of specific cytokines in blood plasma as predictive markers COVID-associated mortality. Materials and methods. samples 29 patients with PCR-confirmed COVID-19 measured concentrations 47 molecules. These molecules included: interleukins selected pro-inflammatory (IL-1, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-12 (p40), (p70), IL 13, IL-15, IL-17A/CTLA8, IL-17-E/IL-25, IL-17F, IL-18, IL-22, IL-27, IFN2, IFN, TNF,...
The authors reviewed the literature and presented results of their own research post-operative cognitive dysfunction confirming its social importance. development is to be perceived as a real fact despite differences in published epidemiological data. Currently, there are no grounds correlate it directly with general anesthesia given patients, evidence that certain method or drug can reduce frequency clinical decline. There numerous factors within genesis decline they not studied well. All...
Ferritin is one of the biomarkers requiring special attention; its blood level increases significantly especially in severe course COVID-19. Information on effect hyperferritinemia disease outcome very contradictory as are ideas about causes development. The objective: to study and analyse possible development Subjects Methods . Data 479 patients with coronavirus infection treated intensive care units (ICU) were retrospectively analyzed. Of them, proportion a favorable (Group 1) was 51.0% (n...
The objective was to analyze the clinical and economic feasibility of using selective methods lipopolysaccharide (LPS) sorption for sepsis treatment. Materials . A model used assess some technologies sorption. developed in accordance with current industry standard «Clinical Economic Research» Russia. target population patients 18 years old older sepsis. methodology involved evaluation available randomized trials, as well studies involving data from network meta-analyses systematic reviews...
To assess the biology of lethal endpoint in patients with SARS-CoV-2 infection, we compared transcriptional response to virus who survived or died during severe COVID-19. We applied gene expression profiling generate signatures for peripheral blood mononuclear cells (PBMCs) from infection at time when they were placed Intensive Care Unit Pavlov First State Medical University St. Petersburg (Russia). Three different bioinformatics approaches RNA-seq analysis identified a downregulation three...
The objective was to assess the effectiveness and safety of use a fixed combination Diclofenac Orphenadrine (Neodolpasse) for analgesia in patients who underwent knee replacement. Materials methods . 40 replacement conditions combined spinal-conduction (femoral nerve block) were included into study. In main group(n = 20), Neodolpasse (a 75mg 30 mg 250 ml solution) administered intravenously minutes before surgery, then postoperative period 2 times day days. comparison group (n Ketoprofen...
Acute renal injury is a relatively new notion (introduced into the practice since 2012), which currently understood as fast failure of functions (within 48 hours) with increasing absolute rates serum creatinine up to 26.5 mcmol/l and more, relative increase concentration 50% more (i.e. by 1.5 times) versus initial level or documented oliguria diuresis less than 0.5 ml per kg body weight during 6 hours. The frequency acute increases every year especially in patients undergoing massive...
Abstract Background Several anti-cytokine therapies were tested in the randomized trials hospitalized patients with severe acute respiratory syndrome coronavirus 2 infection (COVID-19). Previously, dexamethasone demonstrated a reduction of case-fatality rate failure. In this matched control study we compared to Janus kinase inhibitor, ruxolitinib. Methods The cohort included 146 COVID-19 and oxygen support requirement. group was selected 1:1 from 1355 dexamethasone-treated by main clinical...
The safety and effectiveness of endoscopic rhinological operations in the treatment chronic inflammatory diseases, as well neoplasms paranasal sinuses, are largely achieved by reducing bleeding area surgical field. Even a small amount blood can disrupt view during endoscopy prevent intervention from being performed, thereby increasing risk complications. review presents modern methods intraoperative under general anesthesia. Each approach has its own characteristics, therefore, benefit-risk...
The lecture discusses some aspects of anesthetic and intesive care for patients with blast injuries based on the experience local conflicts ma n-m ade disasters recent decades generalized by national foreign experts. Such casualties are difficult to treat due potential significant anatomical damage development severe functional disorders. Understanding role damaging factors facilitates choice diagnostic therapeutic tactics.
Acute kidney dysfunctions in critically ill patients make a frequent complication. For the last 10 years, significant conceptual changes have occurred this respect: definition of acute failure (stating renal catastrophe) has been replaced with injury; stage disease, preceding development chronic condition defined. It highlights rate developing kidneys after injury, and now it is possible to focus on approaches diagnostics, prevention failure, use replacement therapy. The review presents...
At present, great interest is caused with evaluation of new markers in blood circulation for the estimation a tissue oxidative metabolism disturbance due to presence secondary mitochondrial dysfunction patients coronary heart disease. Сoronary disease generally accompanied decline respiration and represents root cause metabolic abnormalities tissues. To gain insight into rate tissues there were proposed humanin as marker. The content compare other energy 59 was studied. In examined patients,...
Thrombophilia, as well multiple organ dysfunction, are typical manifestations of the severe new coronavirus infection that closely resemble clinical signs catastrophic antiphospholipid syndrome (CAPS). The objective : to assess whether is an essential manifestation forms COVID-19. Subjects and methods. 45 patients diagnosed with (SARS-CoV-2) a course viral pneumonia (more than 3 points on NEWS score by admission, CT 3-4, oxygenation index below 100, need for at least high-flow oxygen...
Objective: complex assessment of clinical and economic effectiveness as well saving the state budget assets within therapy patients with sepsis/septic shock based on different technologies blood purification. Methods. Evaluation direct indirect costs eight purifcation methods. The target population includes adult 18+ septic acute kidney injury. study was conducted in compliance acting Standards Clinical Economic Studies used Russian Federation. methods included evaluation existing randomized...
Purpose: The aim of this research is to develop an accurate and interpretable aggregated score not only for hospitalization outcome prediction (death/discharge) but also the daily assessment COVID-19 patient's condition. Patients Methods: In single-center cohort study, real-world data collected within first two waves pandemic was used (27.04.2020-03.08.2020 01.11.2020-19.01.2021, respectively). wave (1,349 cases) as a training set development, while second (1,453 validation set. No...
ФАРМАКОЭКОНОМИЧЕСКАЯ ОЦЕНКА ИНТЕРМИТТИРУЮЩЕЙ И ПРОДОЛЖИТЕЛЬНОЙ ЗАМЕСТИТЕЛЬНОЙ ПОЧЕЧНОЙ ТЕРАПИИЮ. С. ПОЛУШИН 1 , Д
Microcirculation disorders caused by thrombosis are the most important factor determining pathogenesis of organ damage in severe COVID-19 including absence obvious macrohemodynamic instability. However, there very few publications demonstrating results intravital visualization changes microcirculation system this disease. The objective: to assess state patients with viral pneumonia associated using nail bed microscopy. Subjects and methods. Eleven were examined; they admitted intensive care...
The use of high-adsorption membrane hemofiltration in COVID-19 positive patients to reduce the severity a cytokine storm is clearly beneficial but at same time, there are no certain procedures for its practical use. objective: study change levels IL-6 and IL-18 response prolonged (24-72 hours) hemofiltration. Subjects methods . We retrospectively analyzed data on their changes 69 who were had different degrees lung damage, they received during stay intensive care unit. extent lesions was...
СТРУКТУРНО-ФУНКЦИОНАЛЬНАЯ ПЕРЕСТРОЙКА НЕЙРОНОВ ГИППОКАМПА ПОСЛЕ ОПЕРАЦИИ ПОД АНЕСТЕЗИЕЙ СЕВОФЛУРАНОМ (экспериментальное исследование)Г. Ю. ЮКИНА 1
Introduction . In recent years, much attention has been paid to the study of extracellular microparticles (microvesicles and exosomes) their role in pathogenesis human diseases. The objective this was determine number size plasma (PEMP) patients with severe extremely COVID-19 correlate these data markers hemostasis activation, inflammation, tissue damage. Methods Materials included 29 COVID-19. Concentration PEMP were determined by nanoparticle trajectory analysis (NTA). All underwent...