A5046737012- Influenza Virus Research Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- Quinazolinone synthesis and applications
- vaccines and immunoinformatics approaches
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- CRISPR and Genetic Engineering
- Animal Disease Management and Epidemiology
- SARS-CoV-2 detection and testing
- Enzyme Catalysis and Immobilization
- Virology and Viral Diseases
- Immunotherapy and Immune Responses
- Socioeconomic and Demographic Analysis
- Biochemical and Molecular Research
- Bacillus and Francisella bacterial research
- Advanced Measurement and Metrology Techniques
Research Institute of Influenza
2016-2025
Siberian Branch of the Russian Academy of Sciences
2019-2024
Institute of Chemical Biology and Fundamental Medicine
2019-2024
Ministry of Health of the Russian Federation
2014-2024
Central Dermatology
2023
Moscow State Institute of International Relations
2021
Peter the Great St. Petersburg Polytechnic University
2021
Federal State Budgetary Institution of Science "Scientific and Technological Center of Unique Instrumentation" of the Russian Academy of Sciences
2019
Hochschule Aalen
2010
Albany Molecular Research (United States)
2000
Abstract Evolution of SARS-CoV-2 in immunocompromised hosts may result novel variants with changed properties. While escape from humoral immunity certainly contributes to intra-host evolution, cellular is poorly understood. Here, we report a case long-term COVID-19 an patient non-Hodgkin’s lymphoma who received treatment rituximab and lacked neutralizing antibodies. Over the 318 days disease, genome gained total 40 changes, 34 which were present by end study period. Among acquired mutations,...
The process of reversible denaturation several proteins (alpha-chymotrypsin, trypsin, laccase, chymotrypsinogen, cytochrome c and myoglobin) by a broad series organic solvents different nature was investigated using both our own literature data, based on the results kinetic spectroscopic measurements. In all systems studied, proceeded in threshold manner, i.e. an abrupt change catalytic and/or properties dissolved observed after certain concentration solvent had been reached. To account for...
Abstract The ongoing pandemic of SARS-CoV-2 presents novel challenges and opportunities for the use phylogenetics to understand control its spread. Here, we analyze emergence in Russia March April 2020. Combining phylogeographic analysis with travel history data, estimate that sampled viral diversity has originated from at least 67 closely timed introductions into Russia, mostly late February early March. All but one these were not China, suggesting border closure China helped delay...
BackgroundA new inactivated whole-virion QazCovid-in® vaccine against COVID-19 was developed from SARS-CoV-2 isolated in Kazakhstan, by formaldehyde, and adjuvanted with aluminium hydroxide. Phase 1 2 clinical trials aimed at assessing the vaccine's safety, immunogenicity, duration of immunity induced after one or two immunisations.MethodsFrom 23.09.2020 to 19.03.2021 we performed a randomised, single-blind, placebo-controlled phase trial 18.10.2020 17.04.2021 an open-label 6 months...
Vaccination remains the primary measure to prevent spread of SARS-CoV-2 virus, further necessitating use effective licensed vaccines.From Dec 25, 2020, July 11, 2021, we conducted a multicenter, randomised, single-blind, placebo-controlled phase 3 efficacy trial QazCovid-in® vaccine with 180-day follow-up period in three clinical centres Kazakhstan. A total 3000 eligible participants aged 18 years or older were randomly assigned (4:1) receive two doses (5 μg each, 21 days apart) placebo...
Matrix 2 protein ectodomain (M2e) is considered a promising candidate for broadly protective influenza vaccine. M2e-based vaccines against human A provide only partial protection avian viruses because of differences in the M2e sequences. In this work, we evaluated possibility obtaining equal and immune response by using recombinant on basis flagellin as carrier peptides viruses. Recombinant was generated fusion two tandem copies consensus sequence from A/H5N1 to (Flg-2M2eh2M2ek). Intranasal...
Long-term tendencies in the Russian labour market of last decade determined need for qualitative transformations. The change from ‘limited demand’ to supply’ at background resources deficit and economic shocks limits extent effective use previous reaction mechanisms market. Due impossibility quick democgraphic changes, one most potential ways solve crisis is freeing force by digitalization spheres create reserves others more high-tech spheres. This process requires parallel technological...
This article, referring to the structural-infrastructure approach, carries out a conceptual division of labor market problems and development problems. Labor are emerging difficulties in functioning established mechanism interaction between agents. understood as that economy faces when from crisis (when choosing path). A marks period mechanisms within system relations cannot fully respond resolve challenges. As result, choice – intensive (qualitative) or extensive (quantitative)...
Inactivated vaccines are promising tools for tackling the COVID-19 pandemic. We applied several protocols SARS-CoV-2 inactivation (by β-propiolactone, formaldehyde, and UV radiation) examined morphology of viral spikes, protein composition preparations, their immunoreactivity in ELISA using two panels sera collected from convalescents people vaccinated by Sputnik V. Transmission electron microscopy (TEM) allowed us to distinguish wider flail-like spikes (supposedly S-protein’s pre-fusion...
A dramatic increase of influenza activity in Russia since week 3 2016 significantly differs from previous seasons terms the incidence and acute respiratory infection ( ARI ) number lethal cases. We performed antigenic analysis 108 whole‐genome sequencing 77 A(H1N1)pdm09 viruses Moscow Saint Petersburg. Most were antigenically related to vaccine strain. Whole‐genome revealed a composition specific mutations internal genes (D2E M83I NEP , E125D NS 1, M105T NP Q208K M1, N204S PA ‐X) that...
Abstract Geographical variation in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spread requires seroprevalence studies based on local tests, but robust validation is needed. We summarize an evaluation of antibody tests used a serological study SARS‐CoV‐2 Saint Petersburg, Russia. validated three different assays: chemiluminescent microparticle immunoassay (CMIA) Abbott Architect immunoglobulin G (IgG), enzyme linked immunosorbent assay (ELISA) CoronaPass total antibodies...
Type III interferons (lambda IFNs) are a quite new, small family of three closely related cytokines with interferon-like activity. Attention to IFN-λ is mainly focused on direct antiviral activity in which, as IFN-α, viral genome replication inhibited without the participation immune system cells. The heterodimeric receptor for lambda exposed epithelial cells, which limits its possible action other thus reducing likelihood developing undesirable side effects compared type I IFN. In this...
New strategies providing protection against tuberculosis (TB) are still pending. The airborne nature of Mycobacterium (M.tb) infection assumes that the mucosal delivery TB vaccine could be a more promising strategy than systemic route immunization. We developed candidate based on recombinant attenuated influenza vector (Flu/THSP) co-expressing truncated NS1 protein NS1(1–124) and full-length TB10.4 HspX proteins M.tb within an open reading frame. Flu/THSP was safe stimulated TB-specific CD4+...
Intranasal vaccination using influenza vectors is a promising approach to developing vaccines against respiratory pathogens due the activation of mucosa-associated immune response. However, there no clear evidence vector design that could be considered preferable. To find optimal structure an with modified NS genomic segment, we constructed four expressing identical transgene sequences inherited from F protein syncytial virus (RSV). Two were designed aiming at accumulation in cytosol....
Egg-derived viruses are the only available seed material for influenza vaccine production. Vaccine manufacturing is done in embryonated chicken eggs, MDCK or Vero cells. In order to contribute efficient production of vaccines, we investigate whether quality inactivated vaccines influenced by propagation substrate. We demonstrate that H3N2 egg-derived (A/Brisbane/10/07, IVR147, and A/Uruguay/716/07) triggered hemagglutinin (HA) conformational change under less acidic conditions (0.2-0.6 pH...