A5012972000- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Travel-related health issues
- Virus-based gene therapy research
- Pneumonia and Respiratory Infections
- Animal Disease Management and Epidemiology
- Pediatric health and respiratory diseases
- Human Health and Disease
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Healthcare Systems and Public Health
- Bacteriophages and microbial interactions
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- interferon and immune responses
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Data-Driven Disease Surveillance
Research Institute of Influenza
2016-2025
Ministry of Health of the Russian Federation
2014-2023
City Clinical Hospital
2014
Texas Research Institute
1996
Centers for Disease Control and Prevention
1996
Baylor College of Medicine
1996
The 2009 H1N1 pandemic highlighted the need to routinely monitor severe influenza, which lead establishment of sentinel hospital-based surveillance acute respiratory infections (SARI) in several countries Europe. objective this study is describe characteristics SARI patients and explore risk factors for a outcome influenza-positive patients.Data on hospitalised meeting syndromic case definition between 2012 from nine Eastern Europe (Albania, Armenia, Belarus, Georgia, Kazakhstan, Kyrgyzstan,...
Abstract Background Since 2011, the Global Influenza Hospital Surveillance Network (GIHSN) has used active surveillance to prospectively collect epidemiological and virological data on patients hospitalized with influenza virus infection. Here, we describe strain circulation in GIHSN participant countries during 2017–2018 season examine factors associated complicated hospitalization among admitted laboratory-confirmed illness. Methods The study enrolled who were a hospital previous 48 h...
The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the progressed, resumed. Here, we describe epidemic of high intensity 2022–2023 season. an early start and peaked in week 51.2022. extremely may have been due to significant decrease herd immunity. results PCR-testing 220,067 clinical samples revealed that A(H1N1)pdm09 virus dominated, causing 56.4% positive cases, while A(H3N2) subtype accounted for only 0.6%, B Victoria lineage—for 34.3%. vaccine was...
Abstract Background The Global Influenza Hospital Surveillance Network (GIHSN) was established in 2012 to conduct coordinated worldwide influenza surveillance. In this study, we describe underlying comorbidities, symptoms, and outcomes patients hospitalized with influenza. Methods Between November 2018 October 2019, GIHSN included 19 sites 18 countries using a standardized surveillance protocol. infection laboratory-confirmed reverse-transcription polymerase chain reaction. A multivariate...
ABSTRACT Respiratory viruses represent a significant public health threat. There is the need for robust and coordinated surveillance to guide global responses. Established in 2012, Global Influenza Hospital Surveillance Network (GIHSN) addresses this by collecting clinical virological data on persons with acute respiratory illnesses across network of hospitals worldwide. GIHSN utilizes standardized patient enrolment collection protocol its study sites. It leverages pre‐existing national...
In a blinded, placebo-controlled study, the reactogenicity, immunogenicity, and clinical efficacy of single doses US inactivated split-virus Russian live attenuated, cold-adapted influenza vaccines were compared in 555 schoolchildren Vologda, Russia. Serial serum samples collected school absenteeism was assessed. Systemic reactions rare, but local (primarily erythema at injection site) observed 27% vaccine group, coryza (12%) sore throat (8%) attenuated group. At 4 weeks after vaccination,...
Influenza is a global public health problem. However, severe influenza only recently has been addressed in routine surveillance. The Global Hospital Surveillance Network (GIHSN) was established to study the epidemiology of consecutive seasons different countries. Our objective describe GIHSN approach and methods. uses prospective active surveillance identify admissions permanent residents well-defined geographic areas sites around world. A core common protocol followed. After consent, data...
The Global Influenza Hospital Surveillance Network (GIHSN) has established a prospective, active surveillance, hospital-based epidemiological study to collect and virological data for the Northern Southern Hemispheres over several consecutive seasons. It focuses exclusively on severe cases of influenza requiring hospitalization. A standard protocol is shared between sites allowing comparison pooling results. During 2014-2015 season, GIHSN included seven coordinating from six countries (St....
The Global Influenza Hospital Surveillance Network (GIHSN) was developed to improve understanding of severe influenza infection, as represented by hospitalized cases. GIHSN is composed coordinating sites, mainly affiliated with health authorities, each which supervises and compiles data from one seven hospitals. This report describes the distribution viruses A(H1N1), A(H3N2), B/Victoria, B/Yamagata resulting in hospitalization during 2012–2013, network's first year. In included 21 hospitals...
Background. Integrative epidemiological and etiological analysis of peculiarities the development COVID-19 pandemic in different countries world is significant scientific practical interest order to improve preparedness medical social services during upcoming pandemics. The purpose research. To determine features epidemic process caused by a new coronavirus infection COVID-19, all diversity its interaction with influenza viruses other ARVI agents Russian Federation. Materials methods....
Background The effectiveness of currently licensed vaccines against influenza has not been clearly established, especially among individuals at increased risk for complications from influenza. We used a test-negative approach to estimate vaccine (IVE) hospitalization with laboratory-confirmed based on data collected the Global Influenza Hospital Surveillance Network (GIHSN). Methods and Findings This was multi-center, prospective, active surveillance, hospital-based epidemiological study...
A dramatic increase of influenza activity in Russia since week 3 2016 significantly differs from previous seasons terms the incidence and acute respiratory infection ( ARI ) number lethal cases. We performed antigenic analysis 108 whole‐genome sequencing 77 A(H1N1)pdm09 viruses Moscow Saint Petersburg. Most were antigenically related to vaccine strain. Whole‐genome revealed a composition specific mutations internal genes (D2E M83I NEP , E125D NS 1, M105T NP Q208K M1, N204S PA ‐X) that...
Abstract Background The Global Influenza Hospital Surveillance Network (GIHSN) has since 2012 provided patient-level data on severe influenza-like-illnesses from >100 participating clinical sites worldwide based a core protocol and consistent case definitions. Methods We used multivariable logistic regression to assess the risk of intensive care unit admission, mechanical ventilation, in-hospital death among hospitalized patients with influenza explored role covariates country income...
Influenza circulation was substantially reduced after March 2020 in the European region and globally due to wide introduction of non-pharmaceutical interventions (NPIs) against COVID-19. The virus, however, has been actively circulating natural reservoirs. In summer 2021, NPIs were loosened Russia, influenza activity resumed shortly thereafter. Here, we summarize epidemiological virological data on epidemic Russia 2021-2022 obtained by two National Centers. We demonstrate that commonly used...
The Global Influenza Hospital Surveillance Network is an international platform whose primary objective to study severe cases of influenza requiring hospitalization. During the 2015–2016 season, 11 sites in nine countries (Russian Federation, Czech Republic, Turkey, France, China, Spain, Mexico, India, and Brazil) participated a prospective, active-surveillance, hospital-based epidemiological study. infection was confirmed by reverse transcription-polymerase chain reaction. vaccine...
Analysis of changes in the population immunity level adults for more than 20 Russian cities, collaborating with Federal Center Influenza, to circulating influenza viruses A(H1N1)pdm09, A(H3N2) and B period from 2009 2015 performed. By beginning pandemic (October 2009) Russia was almost seronegative A(H1N1)pdm09 virus. After pandemia first wave mean geometric titers (GMT)s antibodies virus increased by 2.6 times, after second one 4.9 times comparison initial GMT (1:5.5). A consistent increase...
Continuous surveillance for genetic changes in circulating influenza viruses is needed to guide prevention and control.To compare intra-seasonal diversity of hemagglutinin A strains isolated from hospital admissions collected at two distinct sites during the same season.Comparative phylogenetic analysis full-length genes 77 St. Petersburg, Russian Federation Valencia, Spain Global Influenza Hospital Surveillance Network (GIHSN) 2013/14 season.We found significant variability A(H3N2)...
Целью работы было сравнение показателей интенсивности эпидемии гриппа, вызванной штаммами вирусов гриппа А(H3N2) и В, в сезон 2014–2015 гг. с предшествующей эпидемией 2013–2014 Особое внимание уделено летальным исходам от гриппа. Использована база данных НИИ по еженедельной заболеваемости, госпитализации, ОРЗ различных возрастных группах населения 59-ти наблюдаемых городов, расположенных семи Федеральных округах Российской Федерации. По сравнению 2014 г. эпидемия началась раньше (в декабре)...
Goal of the work - comparison epidemic process in 2016 and during 2009 pandemic cities Russia. Comparative data incidence influenza acute respiratory viral infections, hospitalization mortality different age groups children (0 2, 3 6 7 -14 years) adults (15 64 65 years age) from 59 collaborating with 2 National Centers for to WHO Russia, period 2016. For 2016, as was characterized by mono etiology (influenza virus A(H1N1)pdm09, simultaneous occurrence peak all groups, same percentage...
To assess an effect of vaccination on the level humoral anti-influenza herd immunity, 2955 sera were collected and analyzed by HIT in 2019–2020 2020–2021 epidemiological seasons. All obtained from healthy adult donors residing various cities Russian Federation. Among them, 1057 volunteers vaccinated with seasonal influenza trivalent inactivated vaccine. Characteristics immunity (average geometric antibody titers proportion individuals seropositive for vaccine viruses) autumn 2019 2020 (1–2...
Influenza and respiratory syncytial virus (RSV) are among the leading causes of lower tract infections worldwide. We conducted a comparative analysis age distribution spatiotemporal epidemiology influenza RSV in Russia using sentinel surveillance data from 2013-14 to 2018-19 six cities located western, central, eastern regions country.We calculated positivity rate for (by month, season, overall) each city, separately patients seen at primary secondary care level (out-patients medical centres...
Existing influenza surveillance system is constantly improved to obtain comprehensive information for understanding of continuously changing situation with the influenza, which a consequence highest variability pathogen, its ability reassortment and imminence emergence new shift-variants virus that could cause next pandemic events. For this purpose, since 2010 - 2011 epidemic season, in addition traditional (TS) well standardized sentinel (SS) rapid clinical epidemiological data obtaining...
The goal of this work is to compare the key parameters influenza epidemics different etiology. Four with predominance A(H1N1)pdm09 and 4 A(H3N2) were analyzed using database Federal State Research Institute Influenza on morbidity, hospitalization, deaths from in 59 cities period 2009 2017. intensity involving decreased high medium, while increased low medium. In epidemic total population, incidence ARI by a factor 1.6, mortality among patients 1.7 all age groups, except for those over 65...
Human respiratory syncytial virus (RSV) is the most common cause of upper and lower tract infections in infants young children. It actively evolving under environmental herd immunity influences. This work presents, for first time, sequence variability analysis RSV G gene protein using St. Petersburg (Russia) isolates. Viruses were isolated a cell culture from clinical samples 61 children hospitalized (January-April 2014) with laboratory-confirmed infection. Real-time RT-PCR data showed that...
Abstract The expansion and standardization of clinical trials, as well the use sensitive specific molecular diagnostics methods, provide new information on age-specific roles influenza other respiratory viruses in development severe acute infections (SARI). Here, we present results multicenter hospital-based study aimed to detect impact (ORV). 2018–2019 season Russia was characterized by co-circulation A(H1N1)pdm09 A(H3N2) virus subtypes which were detected among hospitalized patients with...