A5100663844- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and Catalytic Reactions
- Metal-Catalyzed Oxygenation Mechanisms
- Catalytic C–H Functionalization Methods
- Electrocatalysts for Energy Conversion
- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Lipid metabolism and biosynthesis
- Porphyrin and Phthalocyanine Chemistry
- Retinoids in leukemia and cellular processes
- Acute Myeloid Leukemia Research
- Viral gastroenteritis research and epidemiology
- Metal complexes synthesis and properties
- Electrochemical Analysis and Applications
- Acute Lymphoblastic Leukemia research
- Asymmetric Hydrogenation and Catalysis
- Photosynthetic Processes and Mechanisms
- Ammonia Synthesis and Nitrogen Reduction
- DNA Repair Mechanisms
- HIV/AIDS drug development and treatment
- Synthetic Organic Chemistry Methods
- Advanced Photocatalysis Techniques
- Cancer therapeutics and mechanisms
- Oxidative Organic Chemistry Reactions
Korea Basic Science Institute
2016-2025
Chung-Ang University
2023-2025
The Ohio State University
2018-2024
Ewha Womans University
2008-2023
Incheon National University
2020-2023
Government of the Republic of Korea
2016-2021
Seoul Institute
2016-2021
Korea University
2021
Green Cross (South Korea)
2021
Sungkyunkwan University
1998-2020
Abstract The development of efficient and stable water oxidation catalysts is necessary for the realization practically viable water-splitting systems. Although extensive studies have focused on metal-oxide catalysts, effect metal coordination catalytic ability remains still elusive. Here we select four cobalt-based phosphate with various cobalt- phosphate-group as a platform to better understand activity materials. they exhibit activities stabilities during oxidation, Na 2 CoP O 7 distorted...
The development of a water oxidation catalyst has been demanding challenge in realizing splitting systems. asymmetric geometry and flexible ligation the biological Mn4CaO5 cluster are important properties for function photosystem II, these can be applied to design new inorganic catalysts. We identified crystal structure, Mn3(PO4)2·3H2O, that precipitates spontaneously aqueous solution at room temperature demonstrated its high catalytic performance under neutral conditions. bulky phosphate...
Abstract Terminal cobalt(IV)–oxo (Co IV –O) species have been implicated as key intermediates in various cobalt-mediated oxidation reactions. Herein we report the photocatalytic generation of a mononuclear non-haem [(13-TMC)Co (O)] 2+ ( 2 ) by irradiating [Co II (13-TMC)(CF 3 SO )] + 1 presence [Ru (bpy) ] , Na S O 8 and water an oxygen source. The intermediate was also obtained reacting with artificial oxidant (that is, iodosylbenzene) characterized spectroscopic techniques. In particular,...
Abstract Genome editing has been harnessed through the development of CRISPR system, and from Prevotella Francisella 1 (Cpf1) system emerged as a promising alternative to CRISPR-Cas9 for use in various circumstances. Despite inherent multiple advantages Cpf1 over Cas9, adoption unsatisfactory because target-dependent insufficient indel efficiencies. Here, we report an engineered RNA (crRNA) highly efficient genome by Cpf1, which includes 20-base target-complementary sequence uridinylate-rich...
Electrocatalytic conversion of CO2 into value-added products offers a new paradigm for sustainable carbon economy. For active electrolysis, the single-atom Ni catalyst has been proposed as promising from experiments, but an idealized Ni–N4 site shows unfavorable energetics theory, leading to many debates on chemical nature responsible high activity. To resolve this conundrum, here we investigated electrolysis sites with well-defined coordination, tetraphenylporphyrin (N4–TPP) and...
Objectives: To present the pharmacokinetics and computed tomographic imaging efficacy of colloidal gold nanoparticles (AuNPs) as a blood-pool agent for x-ray tomography (CT). Methods Materials: prepare AuNPs, nanocrystals were modified using sulfhydrated polyethylene glycol (PEG). Cytotoxicity histopathologic tests carried out toxicity evaluation. Six adult Balb/c mice underwent microcomputed scans after injection AuNPs (2.5 μmol Au/g body weight). Four with HT-1080 tumors imaged...
Pharmacological studies suggest a role for CB1 cannabinoid receptors (CB1R) in regulating neurogenesis the adult brain. To investigate this possibility, we measured by intraperitoneal injection of bromodeoxyuridine (BrdU), which labels newborn neurons, wild-type and CB1R-knockout (CB1R-KO) mice. CB1R-KO mice showed reductions number BrdU-labeled cells to approximately 50% (WT) levels dentate gyrus subventricular zone (SVZ), suggesting that CB1R activation promotes neurogenesis. test further,...
Background Sirtuins (Sirt), a family of nicotinamide adenine nucleotide (NAD) dependent deacetylases, are implicated in energy metabolism and life span. Among the known Sirt isoforms (Sirt1-7), Sirt3 was identified as stress responsive deacetylase recently shown to play role protecting cells under conditions. Here, we demonstrated presence neurons, characterized neuron survival NMDA-induced excitotoxicity. Methodology/Principal Findings To induce excitotoxic injury, exposed primary cultured...
The development of active water oxidation catalysts is critical to achieve high efficiency in overall splitting. Recently, sub-10 nm-sized monodispersed partially oxidized manganese oxide nanoparticles were shown exhibit not only superior catalytic performance for oxygen evolution, but also unique electrokinetics, as compared their bulk counterparts. In the present work, water-oxidizing mechanism MnO was investigated using integrated situ spectroscopic and electrokinetic analyses. We...
Mn5O8 nanoparticles (NPs) were obtained via the controlled oxidation of MnO NPs. The oxygen evolution reaction (OER) properties NPs evaluated using cyclic voltammetry (CV). A current density 5 mA/cm2 was reached when 580 mV overpotential applied at pH 7.8. Electron paramagnetic resonance (EPR) analysis conducted to investigate origin high OER activity From EPR analysis, Mn3+ found be involved in process materials.
Abstract Nitrate is a pervasive aquatic contaminant of global environmental concern. In nature, the most effective nitrate reduction reaction (NRR) catalyzed by reductase enzymes at neutral pH, using highly‐conserved Mo center ligated mainly oxo and thiolate groups. Mo‐based NRR catalysts mostly function in organic solvents with low water stability. Recently, an oxo‐containing molybdenum sulfide nanoparticle that serves as catalyst pH was first reported. Herein, nanoparticle‐catalyzed system...
Abstract The oxygen evolution reaction (OER) is considered a major bottleneck in the overall water electrolysis process. In this work, highly active manganese oxide nano-catalysts were synthesized via hot injection. Facile surface treatment generated Mn(III) species on monodisperse 10 nm MnO nanocrystals (NCs). Size dependency of NCs OER activity was also investigated. Surprisingly, partially oxidized only required 530 mV @ 5 mA cm −2 under near neutral conditions.
Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to down-regulate IFN inflammatory responses viral infections, although functions mechanisms in modulating innate immunity remain unclear. Here, we show that suppresses immune infections stimuli inhibiting nuclear factor-κB (NF-κB) activation type I interferon (IFN-I) induction. Compared with control cells,...
Mn4+ -doped fluoride phosphors have been widely used in wide-gamut backlighting devices because of their extremely narrow emission band. Solid solutions Na2 (Six Ge1-x )F6 :Mn4+ and (Gey Ti1-y were successfully synthesized to elucidate the behavior zero-phonon line (ZPL) different structures. The ratio between ZPL highest intensity υ6 phonon sideband exhibits a strong relationship with luminescent decay rate. First-principles calculations are conducted model variation structural electronic...
Epoxides are versatile chemical intermediates that used in the manufacture of diversified industrial products. For decades, thermochemical conversion has long been employed as primary synthetic route. However, it several drawbacks, such harsh and explosive operating conditions, well a significant greenhouse gas emissions problem. In this study, we propose an alternative electrocatalytic epoxidation reaction, using [CoIII(TAML)]- (TAML = tetraamido macrocyclic ligand) molecular catalyst....
A three-component electrophilic reaction transforms olefins into imidazoline and diamine derivatives (see scheme). Rhodium(II) heptafluorobutyrate dimer (2 mol %) was utilized as the catalyst N,N-dichloro-p-toluenesulfonamide (TsNCl2) acetonitrile nitrogen sources. Modest to good yields (45–82 high regio- stereoselectivity were achieved.
A phase I dose-escalation clinical trial of peritumoral injections interleukin 12 (IL-12)-transduced autologous fibroblasts was performed in patients with disseminated cancer for whom effective treatment does not exist. The goals this study were to assess the safety and toxicities as well efficacy, ancillarily immunomodulatory effects, IL-12 gene transfer. Primary dermal cultured from transduced retroviral vector carrying human genes (p35 p40) neomycin phosphotransferase (TFG-hIL-12-Neo)....
The source of the problem: Experiments with isotopically labeled water can be used to unambiguously assign oxygen in a nonheme manganese(IV) oxo complex. complex, which was generated using as an and cerium(IV) oxidant (see picture), shows reactivities activation CH bonds alkyl-functionalized aromatic molecules oxidation substrates (sub) benzyl alcohol. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or...
The development of denitrification catalysts which can reduce nitrate and nitrite to dinitrogen is critical for sustaining the nitrogen cycle. However, regulating selectivity has proven be a challenge, due difficulty controlling complex multielectron/proton reactions. Here we report that utilizing sequential proton-electron transfer (SPET) pathways viable strategy enhance electrochemical an oxo-molybdenum sulfide electrocatalyst toward reduction exhibited volcano-type pH dependence with...